Results 41 to 50 of about 118,415 (245)

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Method to Evaluate the Kinetics of Bainite Transformation in Low-Temperature Nanobainitic Steel Using Thermal Dilatation Curve Analysis

Metals, 2017
The aim of this work was to develop a method to evaluate the kinetics of bainite transformation by theoretical deduction and thermal dilatation curve analysis. A Gleeble-3500 thermomechanical simulator and dilatometer (DIL805A) were employed to study the
Yaowen Xu, Guang Xu, Xinping Mao, Gang Zhao, Siqian Bao   +4 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Austenite Formation Kinetics of Dual-Phase Steels: Insights from a Mixed-Control Model Under Different Heating Conditions

Modelling
A semi-analytical mixed-control model based on the Non-Partitioned Local Equilibrium (NPLE) assumption was developed to simulate the austenite phase transformation kinetics during heating and isothermal processes. The model was validated by comparing the
Huifang Lan, Xiaoying Hui, Jiangbo Du, Shuai Tang, Linxiu Du   +4 more
doaj   +1 more source

Effect of Heating Rate on the Kinetics of Martensitic Transformation of Ni-Ti-Hf alloys using Differential Scanning Calorimetry (DSC) [PDF]

Materials Research
The transformation martensite-austenite and Kinetics in Ni-Ti-Hf shape memory alloys (SMAs) were calculated for the first time. The Johnson- Mehl – Avrami- Komogorov (JMAK) equation was used to simulate the transformation Martensite- Austenite, which ...
Glauco R. de F. Brito, Walman B. de Castro, Roniere L. Soares   +2 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Effects of acicular ferrites on crystallography and incomplete transformation of low-carbon low-alloy steel

Journal of Materials Research and Technology
In this study, we investigated the effects of acicular ferrite (AF) on the crystallographic and incomplete transformation characteristics of low-carbon low-alloy steel.
Binbin Wu, Zhiquan Wang, Chengjia Shang, Zhigang Yang, Chi Zhang, Maged Elhefnawey, Li Li   +6 more
doaj   +1 more source

Transformation Kinetics on Mechanical Alloying [PDF]

The Journal of Physical Chemistry B, 2003
We propose and develop a model as an attempt to describe the local mechanism of mechanical alloying. This model is based on the observation of global parameters, such as the volumes of the various phases present in the material, and their transformations during the process.
Vasconcelos, Igor F., de Figueiredo, Reginaldo S.   +1 more
openaire   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source