Results 61 to 70 of about 28,814 (279)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Organizational resilience and transformational leadership for managing complex school systems

Frontiers in Education
IntroductionIn the context of global challenges facing educational institutions, this study explores the dynamics between transformational leadership, collective teacher efficacy, and organizational resilience in school systems. Specifically, it examines
Ayala Zadok, Pascale Benoliel, Chen Schechter   +2 more
doaj   +1 more source

The role of transformational leadership in professional learning communities: Empirical evidence from China [PDF]

Journal of Pedagogical Research
Few existing research examines the relationship between transformational leadership and professional learning communities. This study aims to explore the relationship between transformational leadership and professional learning community components from
Lei Gao, Aida H. A. Hamid, Azlin N. Mansor   +2 more
doaj   +1 more source

The Role of Transformational Leadership and Workplace Spirituality on Organizational Citizenship Behavior: Evidence from Indonesian Customs and Excise [PDF]

, 2020
Rudiyana Rudiyana, Fanny Martdianty
openalex   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

An Applied Approach to Transformational Leadership for Whole School Communities: Perspectives of Primary School and System Leaders

Societies
This paper examines the vision, strategy and leadership support structures for Irish primary schools where leadership is specifically referenced, with focus on links to transformational and distributed school leadership.
Inez Wilson Heenan, Niamh Lafferty, Patricia Mannix McNamara   +2 more
doaj   +1 more source

How transformational leadership influences museums’ performance: a contextual ambidexterity view

, 2021
Francisco Nunes, Alexandra Fernandes, Luís Dias Martins, Generosa do Nascimento   +3 more
openalex   +2 more sources

Job Satisfaction As A Mediation Variable Between The Influence Of Transformational Leadership And Organizational Climate On Organizational Citizenship Behavior (Ocb) In Regional Drinking Water Company District Of Cilacap [PDF]

, 2020
Alfato Yusnar Kharismasyah, Yudhistira Pradipta, Toufan Aldian Syah   +2 more
openalex   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source