Results 91 to 100 of about 1,364,752 (208)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Transformative Branding: Are Brands Truly Making a Difference? An Exploration Into the Transformative Branding Practices of Real-World Brands.

, 2023
Transformative branding is a powerful, dynamic, and complex process and a true force for good. Enacting transformative branding can facilitate a more sustainable and equitable market and societal system.
Mulangath Unnikrishnan, Krishnakala
core  

Transformatieve agency van docenten tijdens een Change Laboratory in het hoger onderwijs

Pedagogische Studiën
Onderwijsinnovaties in het hoger onderwijs met blijvende impact vereisen een collaboratieve en systemische aanpak met ruimte voor teacher agency. Deze aspecten zijn de kracht van de Change Laboratory (CL)-methodiek.
Arjen de Vetten, Max Kusters, Marije Schneider, Tim Stevens   +3 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Transformative decisions [PDF]

, 2018
Some of the most fundamental decisions we make in our lives – such as becoming a parent or moving to a different part of the world – are transformative.
Reuter, K., Reuter, Kevin, Messerli, Michael; https://orcid.org/, Messerli, Michael, Reuter, Kevin; https://orcid.org/, Messerli, M.   +5 more
core   +2 more sources

Transformative agency of students as a resource to form civic consciousness in education system

Образование и наука
Introduction. The relevance of the study is associated with the need for the formation of civic consciousness among the young generation. It is important to create mechanisms for involving young people in active creative activity through volunteering and
M. V. Pevnaya, A. N. Tarasova, D. F. Telepaeva, D. S. Protasov   +3 more
doaj   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

From Social Barriers to Transformative Planning in Energy Transitions: Learning from Norwegian Planners' Perspectives

Urban Planning
This study investigates social barriers in Norwegian urban energy projects from the planner’s perspective, bridging institutional and reflexive approaches in the field of planning.
Bradley Loewen
doaj   +1 more source

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Meaning, Agency, and Morality

Studia Universitatis Babeș-Bolyai. Philosophia
In this paper, meaning in a human life is related to transformative agency, by which an agent commits herself to goals and projects that go beyond the satisfaction of her self-centred interests.
Per BAUHN
doaj   +1 more source