Results 81 to 90 of about 1,364,752 (208)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

From Transformative Agency to AI Literacy: Profiling Slovenian Technical High School Students Through the Five Big Ideas Lens

Systems
The rapid spread of artificial intelligence (AI) in education means that students need to master both AI literacy and personal agency. This study situates a sample of 425 Slovenian secondary technical students within a three-tier framework that maps ...
Stanislav Avsec, Denis Rupnik
doaj   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Towards transformative adaptation: experimenting participatory backcasting in Dar es Salaam (Tanzania)

, 2015
This contribution focuses on climate change adaptation in urban context, which is currently a relevant challenge and a field of growing interest for urban and environmental planners.
FALDI, GIUSEPPE
core  

Transformative (h)activism: Breast cancer awareness and the "World of Warcraft" Running of the Gnomes

, 2017
Players of the massively multiplayer online role-playing game World of Warcraft (WoW) are accustomed to a transformative culture that appropriates off-line events and personas into virtual-world representations inside of the game. Following this culture,
Lauren B. Collister, Collister, Lauren B.   +1 more
core   +1 more source

Developing teacher expertise through the Change Laboratory in a Japanese elementary school

Cogent Education
This study investigates how a Change Laboratory intervention fostered teachers’ professional learning and the emergence of new forms of expertise in a Japanese elementary school.
Katsuhiro Yamazumi
doaj   +1 more source

Healing Brazil's Blue Amazon: The Role of Knowledge Networks in Nurturing Cross-Scale Transformations at the Frontlines of Ocean Sustainability

Frontiers in Marine Science, 2018
HIGHLIGHTSThe Anthropocene compels unlocking of ocean-related network capabilities.Orchestration of local, regional, and global knowledge networks can augment transformative capacity.Transdisciplinary network diagnostics are promising social learning ...
Leopoldo C. Gerhardinger, Leopoldo C. Gerhardinger, Leopoldo C. Gerhardinger, Leopoldo C. Gerhardinger, Leopoldo C. Gerhardinger, Philipp Gorris, Philipp Gorris, Philipp Gorris, Leandra R. Gonçalves, Leandra R. Gonçalves, Leandra R. Gonçalves, Leandra R. Gonçalves, Dannieli F. Herbst, Dannieli F. Herbst, Dannieli F. Herbst, Dannieli F. Herbst, Daniele A. Vila-Nova, Daniele A. Vila-Nova, Fabiano G. De Carvalho, Fabiano G. De Carvalho, Fabiano G. De Carvalho, Marion Glaser, Marion Glaser, Marion Glaser, Ruben Zondervan, Ruben Zondervan, Bruce C. Glavovic   +26 more
doaj   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Transformative Outcomes: Assessing and reorienting experimentation with transformative innovation policy [PDF]

, 2020
The impending climate emergency, the commitments made in the Paris agreement and the UN Agenda 2030 Sustainable Development Goals (SDGs) demand significant transformations in the present economies and societies.
Global Comparative History, Kivimaa, P., Environmental Governance, Schot, J.W., Ghosh, B., Dep Geschiedenis en Kunstgeschiedenis, OGKG - Internationale en Politieke geschiedenis, Ramirez, M., Colen Ladeia Torrens, J.   +8 more
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