Results 201 to 210 of about 9,299,804 (276)

Dissecting the role of platelet-derived transforming growth factor-β1 in pulmonary fibrosis. [PDF]

Proc Natl Acad Sci U S A
Chong DLW, Scotton CJ, Porter JC.
europepmc   +1 more source

Decoding Biomolecular Phase Separation: From Physiological Roles to Pathological Mechanisms and Therapeutic Biomaterials Design

Advanced Science, EarlyView.
This review systematically elaborates on the mechanisms underlying physiological regulation and pathological dysregulation of biomolecular phase separation. It also summarizes advances in phase‑separation‑targeted therapeutic strategies and the design of functional biomaterials inspired by this process.
Jiawei Zhu, Jingbo Dong, Qiufang Gong, Xuejiao Song, Zhifa Shen, Chao Liang   +5 more
wiley   +1 more source

Retraction: Transforming growth factor-β1 promotes M1 alveolar macrophage polarization in acute lung injury by up-regulating DNMT1 to mediate the microRNA-124/PELI1/IRF5 axis. [PDF]

Front Cell Infect Microbiol
Frontiers Editorial Office.
europepmc   +1 more source

Mechanically Regulated Secretion: How Physical Forces Instruct the Secretory Pathway and Remodel the Secretome

Advanced Science, EarlyView.
Mechanical cues, including ECM stiffness, stretch, compression, shear stress, and traction forces, remodel trafficking across the secretory pathway, from the ER and Golgi to endolysosomal compartments and the plasma membrane. The resulting secretome reshapes ECM composition and tissue mechanics, establishing feedback loops that support homeostasis or ...
Domenico Russo, Seetharaman Parashuraman, Maria Luigia Maresca, Angela Francesca Dinoi, Alessia Calcagnì, Riccardo Rizzo   +5 more
wiley   +1 more source

Determination of both the expression and serum levels of epidermal growth factor and transforming growth factor β1 genes in COVID-19. [PDF]

Sci Rep
Yildiz Gulhan P, Eroz R, Ozturk CE, Yekenkurul D, Altinsoy HB, Gulec Balbay E, Ercelik M, Davran F, Yildiz S.   +8 more
europepmc   +1 more source

Cellular Mechanisms Enabling Mitochondria Transfer and Transplantation

Advanced Science, EarlyView.
Mitochondrial transfer and transplantation (mitoTT) is examined as a multistep process governed by distinct transfer routes and post‐transfer checkpoints. Mechanisms controlling mitochondrial uptake, network integration, cristae remodeling, mtDNA maintenance, immune sensing, and quality control are highlighted, revealing key biological and ...
F. Seyma Gokdemir, Yagmur Ozendi, Gokhan Burcin Kubat, Keshav K. Singh   +3 more
wiley   +1 more source

Inhibitory effect of MLC901 on axonal demyelination in experimental animals undergoing circumferential lumbal stenosis by increasing transforming growth factor-β1 levels. [PDF]

Asian Spine J
Sjukur KJ, Adhimarta W, Islam AA, Priyanto B, Qanitha A.   +4 more
europepmc   +1 more source

FAK Mediated Coordination of Extracellular Matrix Remodeling and Cellular Mechanics Impairs Nanomedicine Delivery in Solid Tumors

Advanced Science, EarlyView.
FAK orchestrates a mechanical barrier limiting nanomedicine accumulation in solid tumors by coupling ECM remodeling with cytoskeletal tension. Genetic or pharmacological FAK inhibition dismantles this barrier, enhances clathrin‐mediated uptake and penetration, and overcomes delivery limitations to improve antitumor efficacy.
Tian Zhao, Hao Wu, Yujie Qin, Jingfei Zhu, Ye Huang, Wei Chen, Jiaxuan Yu, Xiang Qin, Shun Li, Junjie Li, Tingting Li, Yiyao Liu   +11 more
wiley   +1 more source

Effect of Laurus nobilis on bacteria and human transforming growth factor-β1. [PDF]

Rev Assoc Med Bras (1992)
Sancer O, Şahin U, Çetin ES, Tepebaşi MY, Cezaroğlu Y, Bilir G, Yünlü S, Koca A.   +7 more
europepmc   +1 more source

3D Bioprinted Blood–Brain–Tumor Barrier Spheroid‐Based In Situ Evaluation of Anticancer Compounds Against Glioblastoma: ROS‐Producing Ruthenium as a Potential Therapeutic Candidate

Advanced Science, EarlyView.
The blood–brain–tumor barrier (BBTB) penetration by anticancer drugs and their effects on glioblastoma (GBM) is assessed using 3D bioprinted‐spheroids. Anticancer drug‐induced U‐87 MG cell death is quantified through in situ imaging of spheroids using a cancer cell death probe. The Ru compound, a partial P‐gp substrate, induces greater tumor‐cell death
Hyunjung Lee, Chan Ho Jeon, Doyun Kim, Minjae Lee, Minji Kwon, Joon Myong Song   +5 more
wiley   +1 more source