Results 1 to 10 of about 169,083 (155)

TGF-ß regulates enamel mineralization and maturation through KLK4 expression. [PDF]

PLoS ONE, 2013
Transforming growth factor-ß (TGF-ß) signaling plays an important role in regulating crucial biological processes such as cell proliferation, differentiation, apoptosis, and extracellular matrix remodeling.
Andrew Cho, Naoto Haruyama, Bradford Hall, Mary Jo S Danton, Lu Zhang, Praveen Arany, David J Mooney, Yassine Harichane, Michel Goldberg, Carolyn W Gibson, Ashok B Kulkarni   +10 more
doaj   +4 more sources

Induction of ß Cell Replication by Small Molecule-Mediated Menin Inhibition and Combined PKC Activation and TGF‑ß Inhibition as Revealed by A Refined Primary Culture Screening [PDF]

Cell Journal, 2021
Objective: Pancreatic β cells are recognized as central players in the pathogenesis of types 1 and 2 diabetes. Efficient and robust primary culture methods are required to interrogate β cell biology and screen potential anti-diabetic therapeutics.
Saghar Pahlavanneshan, Mehrdad Behmanesh, Yaser Tahamtani, Ensiyeh Hajizadeh-Saffar, Mohsen Basiri, Hossein Baharvand   +5 more
doaj   +2 more sources

Oleanolic acid stimulation of cell migration involves a biphasic signaling mechanism

Scientific Reports, 2022
Cell migration is a critical process for wound healing, a physiological phenomenon needed for proper skin restoration after injury. Wound healing can be compromised under pathological conditions.
Javier Stelling-Férez, José Antonio Gabaldón, Francisco José Nicolás   +2 more
doaj   +1 more source

Transforming growth factor Beta 3 is required for excisional wound repair in vivo. [PDF]

PLoS ONE, 2012
Wound healing is a complex process that relies on proper levels of cytokines and growth factors to successfully repair the tissue. Of particular interest are the members of the transforming growth factor family. There are three TGF-ß isoforms-TGF- ß 1, 2,
Mark Le, Rachelle Naridze, Jasmine Morrison, Leah C Biggs, Lindsey Rhea, Brian C Schutte, Vesa Kaartinen, Martine Dunnwald   +7 more
doaj   +1 more source

Identification of Nedd9 as a TGF-β-Smad2/3 Target Gene Involved in RANKL-Induced Osteoclastogenesis by Comprehensive Analysis. [PDF]

PLoS ONE, 2016
TGF-ß is a multifunctional cytokine that is involved in cell proliferation, differentiation and function. We previously reported an essential role of the TGF-ß -Smad2/3 pathways in RANKL-induced osteoclastogenesis.
Yasunori Omata, Shinya Nakamura, Takuma Koyama, Tetsuro Yasui, Jun Hirose, Naohiro Izawa, Takumi Matsumoto, Yuuki Imai, Sachiko Seo, Mineo Kurokawa, Shuichi Tsutsumi, Yuho Kadono, Chikao Morimoto, Hiroyuki Aburatani, Takeshi Miyamoto, Sakae Tanaka   +15 more
doaj   +1 more source

TGF-β1 increases cellular invasion of colorectal neuroendocrine carcinoma cell line through partial epithelial-mesenchymal transition

Biochemistry and Biophysics Reports, 2022
Epithelial–mesenchymal transition (EMT) plays a pivotal role in cancer progression and metastasis in many types of malignancies, including colorectal cancer.
Norihiko Sasaki, Seiichi Shinji, Yuuki Shichi, Toshiyuki Ishiwata, Tomio Arai, Takeshi Yamada, Goro Takahashi, Ryo Ohta, Hiromichi Sonoda, Akihisa Matsuda, Takuma Iwai, Kohki Takeda, Kazuhide Yonaga, Koji Ueda, Sho Kuriyama, Toshimitsu Miyasaka, Hiroshi Yoshida   +16 more
doaj   +1 more source

JARID2 is involved in transforming growth factor-beta-induced epithelial-mesenchymal transition of lung and colon cancer cell lines. [PDF]

PLoS ONE, 2014
Histone methylation plays a crucial role in various biological and pathological processes including cancer development. In this study, we discovered that JARID2, an interacting component of Polycomb repressive complex-2 (PRC2) that catalyzes methylation ...
Shoichiro Tange, Dulamsuren Oktyabri, Minoru Terashima, Akihiko Ishimura, Takeshi Suzuki   +4 more
doaj   +1 more source

Rab31-dependent regulation of transforming growth factor ß expression in breast cancer cells

Molecular Medicine, 2021
Background The small GTP-binding protein Rab31 plays an important role in the modulation of tumor biological-relevant processes, including cell proliferation, adhesion, and invasion.
Susanne Soelch, Nathalie Beaufort, Daniela Loessner, Matthias Kotzsch, Ute Reuning, Thomas Luther, Thomas Kirchner, Viktor Magdolen   +7 more
doaj   +1 more source

Human peritoneal mesothelial cell transformation into myofibroblasts in response to TGF-ß1 in vitro

International Journal of Molecular Medicine, 2011
Peritoneal dissemination is one of the leading causes of death in gastric cancer patients. The interaction between carcinoma cells and the peritoneal lining may play a key role in tumor peritoneal dissemination. Human peritoneal mesothelial cells are a monolayer of squamous epithelial cells covering the peritoneal cavity and forming serosal membranes ...
Zhi-Dong, Lv, Di, Na, Xiao-Yang, Ma, Chong, Zhao, Wei-Jun, Zhao, Hui-Mian, Xu   +5 more
openaire   +3 more sources

Serum Transforming Growth Factor –β1 (TGF-β1) in Asthmatics: Association between Disease Control, Severity and Duration [PDF]

Biochemistry & Analytical Biochemistry, 2015
Rationale: Asthma is a chronic inflammatory disorder of the airways in which many cells and cellular elements play a role. Assessment of airway remodelling by analysis of blood and sputum markers has been developed as non-invasive procedures to bypass tissue biopsy.
openaire   +1 more source