TGF-ß regulates enamel mineralization and maturation through KLK4 expression. [PDF]
PLoS ONE, 2013 Transforming growth factor-ß (TGF-ß) signaling plays an important role in regulating crucial biological processes such as cell proliferation, differentiation, apoptosis, and extracellular matrix remodeling.
Andrew Cho +10 more
doaj +21 more sources
Induction of ß Cell Replication by Small Molecule-Mediated Menin Inhibition and Combined PKC Activation and TGF‑ß Inhibition as Revealed by A Refined Primary Culture Screening [PDF]
Cell Journal, 2021 Objective: Pancreatic β cells are recognized as central players in the pathogenesis of types 1 and 2 diabetes. Efficient and robust primary culture methods are required to interrogate β cell biology and screen potential anti-diabetic therapeutics.
Saghar Pahlavanneshan +5 more
doaj +2 more sources
IL23 and TGF-ß diminish macrophage associated metastasis in pancreatic carcinoma [PDF]
Scientific Reports, 2018 The precise role of tumor associated macrophages remains unclear in pancreatic ductal adenocarcinoma (PDAC) while TGF-ß has an unclear role in metastases formation.
S. Mazher Hussain +12 more
doaj +2 more sources
Prg4 prevents osteoarthritis induced by dominant-negative interference of TGF-ß signaling in mice. [PDF]
PLoS ONE, 2019 ObjectivePrg4, also known as Lubricin, acts as a joint/boundary lubricant. Prg4 has been used to prevent surgically induced osteoarthritis (OA) in mice.
Robert Dalton Chavez +2 more
doaj +2 more sources
Overexpression of T-bet, GATA-3 and TGF-ß Induces IFN-γ, IL-4/13A, and IL-17A Expression in Atlantic Salmon [PDF]
Biology, 2020 The overexpression of GATA-3, T-bet and TGF-ß may theoretically induce IL-4/A, IFN-γ and IL-17A expression, respectively. Whether this also applies to fish is not yet known.
Tiril H. Slettjord +6 more
doaj +2 more sources
TGF-ß Regulates Cathepsin Activation during Normal and Pathogenic Development [PDF]
Cell Reports, 2018 Summary: Cysteine cathepsins play roles during development and disease beyond their function in lysosomal protein turnover. Here, we leverage a fluorescent activity-based probe (ABP), BMV109, to track cysteine cathepsins in normal and diseased zebrafish ...
Heather Flanagan-Steet +8 more
doaj +2 more sources
Hypoxia-driven metastatic progression in synovial sarcoma: insights from SYO-1 and SW982 models [PDF]
BMC CancerBackground Synovial sarcoma (SS) is a rare but aggressive soft tissue malignancy characterized by a high rate of pulmonary metastasis and limited response to conventional therapies. Hypoxia, a common feature of tumor microenvironment, has been implicated
Maria Fueth +12 more
doaj +2 more sources
Oleanolic acid stimulation of cell migration involves a biphasic signaling mechanism
Scientific Reports, 2022 Cell migration is a critical process for wound healing, a physiological phenomenon needed for proper skin restoration after injury. Wound healing can be compromised under pathological conditions.
Javier Stelling-Férez +2 more
doaj +1 more source
Transforming growth factor Beta 3 is required for excisional wound repair in vivo. [PDF]
PLoS ONE, 2012 Wound healing is a complex process that relies on proper levels of cytokines and growth factors to successfully repair the tissue. Of particular interest are the members of the transforming growth factor family. There are three TGF-ß isoforms-TGF- ß 1, 2,
Mark Le +7 more
doaj +1 more source
Identification of Nedd9 as a TGF-β-Smad2/3 Target Gene Involved in RANKL-Induced Osteoclastogenesis by Comprehensive Analysis. [PDF]
PLoS ONE, 2016 TGF-ß is a multifunctional cytokine that is involved in cell proliferation, differentiation and function. We previously reported an essential role of the TGF-ß -Smad2/3 pathways in RANKL-induced osteoclastogenesis.
Yasunori Omata +15 more
doaj +1 more source