Results 31 to 40 of about 29,782 (188)
AntioxidantsCardiovascular diseases are a leading cause of mortality, driving the search for alternative preventive strategies. This study investigates the antioxidant effects, among others, of a mixture of four bioactive peptides (BPs) derived from dry-cured pork ...
Clara Noguera-Navarro +5 more
doaj +1 more source
Sustained hyperosmolarity increses TGF-ß1 and Egr-1 expression in the rat renal medulla
BMC Nephrology, 2017 Background Although TGF-ß and the transcription factor Egr-1 play an important role in both kidney fibrosis and in response to acute changes of renal medullary osmolarity, their role under sustained hypo- or hyperosmolar conditions has not been ...
Miklós M. Mózes +3 more
doaj +1 more source
Dietary soya saponin improves the lipid metabolism and intestinal health of laying hens
Poultry Science, 2022 : Soya saponin (SS) is a natural active substance of leguminous plant, which could improve lipid metabolism and regulate immune function. Intestinal flora might play a key role in the biological functions of SS. The objective of this study was to measure
Peng Li +7 more
doaj +1 more source
IL-10 Inhibits Transforming Growth Factor-ß-Induction of Type I Collagen mRNA Expression via Both JNK and p38 Pathways in Human Lung Fibroblasts [PDF]
Transforming growth factor-ß (TGF-ß) is a key factor for understanding the pathogenesis of fibrotic disorders such as idiopathic pulmonary fibrosis (IPF).
Arai, Toru +13 more
core +1 more source
PAI-1 secretion of endometrial and endometriotic cells is Smad2/3- and ERK1/2-dependent and influences cell adhesion [PDF]
, 2016 In the endometrium transforming growth factor-betas (TGF-ßs) are involved mainly in menstruation and endometriosis. After binding of the ligands to the high-affinity receptors, TGF-ß receptors (TBR1 and TBR2), TGF-ßs activate Smad signaling to modulate ...
Konrad, Lutz +6 more
core +1 more source
Frontiers in Physiology, 2019 The common fruit fly, Drosophila melanogaster, is an outstanding model to study the molecular basis of anti-pathogen immunity. The parasitic nematode Heterorhabditis gerrardi, together with its mutualistic bacteria Photorhabdus asymbiotica, infects a ...
Yaprak Ozakman, Ioannis Eleftherianos
doaj +1 more source
How ubiquitination regulates the TGF-β signalling pathway: New insights and new players [PDF]
, 2011 Ubiquitination of protein species in regulating signal transduction pathways is universally accepted as of fundamental importance for normal development, and defects in this process have been implicated in the progression of many human diseases.
Bai +95 more
core +1 more source
Egr-1 induces a profibrotic injury/repair gene program associated with systemic sclerosis. [PDF]
PLoS ONE, 2011 Transforming growth factor-ß (TGF-ß) signaling is implicated in the pathogenesis of fibrosis in scleroderma or systemic sclerosis (SSc), but the precise mechanisms are poorly understood. The immediate-early gene Egr-1 is an inducible transcription factor
Swati Bhattacharyya +7 more
doaj +1 more source
Journal of Clinical & Cellular Immunology, 2015 Retraction Note The article entitled “Immunophysiological Significance for Differential Receptor Expression of Melatonin (Mel1aR/Mel1bR), Cytokine(s) (IL-2R/IL-10R/TGF-β R) and Tyrosine Hydroxylase (THR) in Lymphocyte Sub-Population: A Novel Crosstalk between Melatonin and Catecholamines” has been accepted for publication in the ...
openaire +1 more source
Signaling in Simple Steatosis and Non-alcoholic Steatohepatitis Cirrhosis: TGF-β1, YAP/TAZ, and Hedgehog Pathway Activity [PDF]
Avicenna Journal of Medical Biochemistry, 2018 Non-alcoholic fatty liver disease (NAFLD) refers to the accumulation of fat in the liver tissue that is usually associated with metabolic disorders. Traditionally, the disease is regarded as a spectrum of pathological conditions ranging from simple ...
Sina Mohagheghi +2 more
doaj +1 more source