Results 31 to 40 of about 169,083 (155)
Signaling in Simple Steatosis and Non-alcoholic Steatohepatitis Cirrhosis: TGF-β1, YAP/TAZ, and Hedgehog Pathway Activity [PDF]
Avicenna Journal of Medical Biochemistry, 2018 Non-alcoholic fatty liver disease (NAFLD) refers to the accumulation of fat in the liver tissue that is usually associated with metabolic disorders. Traditionally, the disease is regarded as a spectrum of pathological conditions ranging from simple ...
Sina Mohagheghi +2 more
doaj +1 more source
Journal of Clinical & Cellular Immunology, 2015 Retraction Note The article entitled “Immunophysiological Significance for Differential Receptor Expression of Melatonin (Mel1aR/Mel1bR), Cytokine(s) (IL-2R/IL-10R/TGF-β R) and Tyrosine Hydroxylase (THR) in Lymphocyte Sub-Population: A Novel Crosstalk between Melatonin and Catecholamines” has been accepted for publication in the ...
openaire +1 more source
Egr-1 induces a profibrotic injury/repair gene program associated with systemic sclerosis. [PDF]
PLoS ONE, 2011 Transforming growth factor-ß (TGF-ß) signaling is implicated in the pathogenesis of fibrosis in scleroderma or systemic sclerosis (SSc), but the precise mechanisms are poorly understood. The immediate-early gene Egr-1 is an inducible transcription factor
Swati Bhattacharyya +7 more
doaj +1 more source
Journal of Cardiovascular Development and Disease, 2023 This study aimed to delineate the effect of sodium chloride on the induction of inflammatory responses and the development of hypertension in Dahl salt-sensitive (SS) and salt-resistant (SR) rats.
Sungmin Jang +3 more
doaj +1 more source
TGF-ß-SMAD-miR-520e axis regulates NSCLC metastasis through a TGFBR2-mediated negative-feedback loop
, 2019 Transforming growth factor-ß (TGF-ß) pathway plays crucial roles during the carcinogenesis and metastasis. TGF-ß receptor 2 (TGFBR2) is a key molecule for the regulation of TGF-ß pathway and frequently downregulated or lost in several cancer types ...
Dal, Egemen +10 more
core +1 more source
TGF-ß suppresses PPAR-γ mRNA expression in fibroblasts.
, 2013 A. Confluent fibroblasts were incubated with 10 ng/ml TGF-ß for indicated period (left panel), or for 24 h with indicated concentrations of TGF-ß (right panel). RNA expression was examined by real-time qPCR.
Jennifer L. Sargent (87901) +9 more
core +1 more source
Biology, 2020 Regulatory T cells (Tregs) are key players in the regulation of inflammatory responses. In this study, two natural molecules, namely, sparteine sulfate (SS) and harpagoside (Harp), were investigated for their ability to induce Tregs in human peripheral ...
Nour Z. Atwany +5 more
doaj +1 more source
Negative correlation between endoglin levels and coronary atherosclerosis
Lipids in Health and Disease, 2021 Background Coronary artery disease (CAD) is a common cardiovascular disease, and abnormal blood lipid metabolism is an important risk factor. Transforming growth factor-ß (TGF-ß) and its receptor (TGF-ßR) can inhibit the release of inflammatory factors ...
Haibin Chen +7 more
doaj +1 more source
Matrix rigidity induces osteolytic gene expression of metastatic breast cancer cells. [PDF]
PLoS ONE, 2010 Nearly 70% of breast cancer patients with advanced disease will develop bone metastases. Once established in bone, tumor cells produce factors that cause changes in normal bone remodeling, such as parathyroid hormone-related protein (PTHrP).
Nazanin S Ruppender +5 more
doaj +1 more source
Reconstitution of TGFBR2-Mediated Signaling Causes Upregulation of GDF-15 in HCT116 Colorectal Cancer Cells. [PDF]
PLoS ONE, 2015 Although inactivating frameshift mutations in the Transforming growth factor beta receptor type 2 (TGFBR2) gene are considered as drivers of microsatellite unstable (MSI) colorectal tumorigenesis, consequential alterations of the downstream target ...
Jennifer Lee +5 more
doaj +1 more source