Results 31 to 40 of about 23,607 (143)

Immunophysiological Significance for Differential Receptor Expression of Melatonin (Mel1aR/Mel1bR), Cytokine(s) (IL-2R/IL-10R/TGF-βR) and Tyrosine Hydroxylase (THR) in Lymphocyte Sub-Population: A Novel Crosstalk between Melatonin and Catecholamines

Journal of Clinical & Cellular Immunology, 2015
Retraction Note The article entitled “Immunophysiological Significance for Differential Receptor Expression of Melatonin (Mel1aR/Mel1bR), Cytokine(s) (IL-2R/IL-10R/TGF-β R) and Tyrosine Hydroxylase (THR) in Lymphocyte Sub-Population: A Novel Crosstalk between Melatonin and Catecholamines” has been accepted for publication in the ...
openaire   +1 more source

Signaling in Simple Steatosis and Non-alcoholic Steatohepatitis Cirrhosis: TGF-β1, YAP/TAZ, and Hedgehog Pathway Activity [PDF]

Avicenna Journal of Medical Biochemistry, 2018
Non-alcoholic fatty liver disease (NAFLD) refers to the accumulation of fat in the liver tissue that is usually associated with metabolic disorders. Traditionally, the disease is regarded as a spectrum of pathological conditions ranging from simple ...
Sina Mohagheghi, Zohreh Khajehahmadi, Heidar Tavilani   +2 more
doaj   +1 more source

Hypertonic Salt Solution Enhances Inflammatory Responses in Cultured Splenic T-Cells from Dahl Salt-Sensitive Rats but Not Dahl Salt-Resistant Rats

Journal of Cardiovascular Development and Disease, 2023
This study aimed to delineate the effect of sodium chloride on the induction of inflammatory responses and the development of hypertension in Dahl salt-sensitive (SS) and salt-resistant (SR) rats.
Sungmin Jang, Jee Young Kim, Cheong-Wun Kim, Inkyeom Kim   +3 more
doaj   +1 more source

NANOS1 restricts oral cancer cell motility and TGF-ß signaling

European Journal of Cell Biology
Oral squamous cell carcinoma (OSCC) is the most frequent type of cancer of the head and neck area accounting for approx. 377,000 new cancer cases every year.
Julia Rosemann, Jonas Pyko, Roland Jacob, Jana Macho, Matthias Kappler, Alexander W. Eckert, Monika Haemmerle, Tony Gutschner   +7 more
doaj   +1 more source

Endothelial Cell Proteins as Biomarkers in Susac Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Susac syndrome (SS) is a rare CD8+ T cell–mediated microangiopathy affecting the brain, retina, and auditory labyrinth. Endothelial injury is thought to be a central mechanism; however, no circulating disease biomarkers are known. We performed targeted proteomic profiling to identify circulating endothelial‐associated proteins as ...
Rohit Benjamin, Yue Andy Qi, Ying Hao, Catherine DeMarino, Samuel Darko, Irene Cortese, Daniel S. Reich, María I. Gaitán, Steven Jacobson, Bridgett J. Billioux, Bryan Smith, Avindra Nath   +11 more
wiley   +1 more source

Induction of CD4⁺CD25⁺ Regulatory T Cells from In Vitro Grown Human Mononuclear Cells by Sparteine Sulfate and Harpagoside

Biology, 2020
Regulatory T cells (Tregs) are key players in the regulation of inflammatory responses. In this study, two natural molecules, namely, sparteine sulfate (SS) and harpagoside (Harp), were investigated for their ability to induce Tregs in human peripheral ...
Nour Z. Atwany, Seyedeh-Khadijeh Hashemi, Manju Nidagodu Jayakumar, Mitzi Nagarkatti, Prakash Nagarkatti, Mona Rushdi Hassuneh   +5 more
doaj   +1 more source

Negative correlation between endoglin levels and coronary atherosclerosis

Lipids in Health and Disease, 2021
Background Coronary artery disease (CAD) is a common cardiovascular disease, and abnormal blood lipid metabolism is an important risk factor. Transforming growth factor-ß (TGF-ß) and its receptor (TGF-ßR) can inhibit the release of inflammatory factors ...
Haibin Chen, Yiping Wang, Bing Sun, Xunxia Bao, Yu Tang, Feifei Huang, Sibo Zhu, Jiahong Xu   +7 more
doaj   +1 more source

Genetic Ablation and Multi‐Omics Profiling Reveal CEP55 as a Key Driver of Tumorigenesis in Diverse Cancer Models

Advanced Science, EarlyView.
Genetic ablation of Cep55 in Pten‐deficient mouse models delays tumorigenesis. Integrated multi‐omics analyses (proteomics, phosphoproteomics, and spatial transcriptomics) reveal that CEP55 regulates oncogenic signaling (RAS/ERK, PI3K/AKT), integrin/FAK‐mediated adhesion, extracellular matrix (ECM) remodeling, and endocytosis.
Behnam Rashidieh, Yuanhao Yang, Amanda Louise Bain, Phillip Theron, Catharina Vosloo, Sahar Keshvari, Parinaz Ahangar, Brydie Bowden, Simon M. Tria, Ben B. Wang, Sandra Isenmann, Nicholas J. Westra van Holthe, Zherui Xiong, Hani Vu, Sowmya Sharma, Asmerom Sengal, J. Alejandro Lopez, John Finnie, Antonella Papa, Pascal H.G. Duijf, Quan Nguyen, Pirjo M. Apaja, Kum Kum Khanna   +22 more
wiley   +1 more source

Matrix rigidity induces osteolytic gene expression of metastatic breast cancer cells. [PDF]

PLoS ONE, 2010
Nearly 70% of breast cancer patients with advanced disease will develop bone metastases. Once established in bone, tumor cells produce factors that cause changes in normal bone remodeling, such as parathyroid hormone-related protein (PTHrP).
Nazanin S Ruppender, Alyssa R Merkel, T John Martin, Gregory R Mundy, Julie A Sterling, Scott A Guelcher   +5 more
doaj   +1 more source

Extracellular Vesicles‐Based Biological Macromolecule Delivery Systems: Biogenesis, Characterization, and Emerging Clinical Applications

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale membrane‐bound structures that play a pivotal role in intercellular communication by transporting bioactive molecules, including proteins, lipids, nucleic acids, and organelles, between cells. Originating from the endosomal pathway, EVs reflect the physiological and pathological status of their parent
Emine İncilay Torunoğlu, Zeynep Betül Sarı, Muhammed Emin Sarı, Erdi Can Aytar   +3 more
wiley   +1 more source