Results 21 to 30 of about 29,782 (188)

Arterial stiffening in western diet-fed mice is associated with increased vascular elastin, transforming growth factor-ß, and plasma neuraminidase [PDF]

, 2016
Consumption of excess fat and carbohydrate (Western diet, WD) is associated with alterations in the structural characteristics of blood vessels. This vascular remodeling contributes to the development of cardiovascular disease, particularly as it affects
Alvira, Aneja, Arribas, Baydanoff, Bender, Billaud, Bizbiz, Blaise, Boak, Briones, Carlson, Castorena-Gonzalez, Clifford, Dantas, Davis, de Onis, DeMarco, Duprez, Emoto, George, Guilherme, Heinemann, Hinek, Hinek, Horiguchi, Huxley, Jia, Jung, Katz, Kielty, Kielty, Kuang, Kucich, Kucich, Kwon, Ledoux, Lesniewski, Majane, Martinez-Lemus, Matthews, McGill, McGowan, Mulvany, Nicoloff, Nistala, Parikh, Payne, Pennington, Roozbeh, Sandow, Sehgel, Shen, Souza-Smith, Sproul, Stehouwer, Stolarczyk, Straub, Sutton-Tyrrell, Talukdar, Toto-Moukouo, Tounian, Trask, van Popele, Wagenseil, Weisbrod, Wildman, Zhou   +66 more
core   +1 more source

TGF-ß alterations in oral squamous cell carcinoma. Narrative review.

Journal of Oral Research, 2016
The transforming growth factor beta (TGF-ß) is a cytokine that plays crucial roles in the regulation of angiogenesis, immune response, proliferation, migration and apoptosis of cells.
Jorge Candia, Carolina Somarriva, Diego Fonseca, Fernando Parada, Jorge Briceño, Alejandra Fernández   +5 more
doaj   +1 more source

PPARγ downregulation by TGFß in fibroblast and impaired expression and function in systemic sclerosis: a novel mechanism for progressive fibrogenesis. [PDF]

PLoS ONE, 2010
The nuclear orphan receptor peroxisome proliferator-activated receptor-gamma (PPAR-γ) is expressed in multiple cell types in addition to adipocytes. Upon its activation by natural ligands such as fatty acids and eicosanoids, or by synthetic agonists such
Jun Wei, Asish K Ghosh, Jennifer L Sargent, Kazuhiro Komura, Minghua Wu, Qi-Quan Huang, Manu Jain, Michael L Whitfield, Carol Feghali-Bostwick, John Varga   +9 more
doaj   +1 more source

SYT-SSX1 enhances the invasiveness and maintains stem-like cell properties in synovial sarcoma via induction of TGF-β1/Smad signaling

BMC Cancer, 2022
Background Synovial sarcoma (SS) is a type of soft tissue sarcoma (STS) of undetermined tissue origin, which is characterized by the recurrent pathognomonic chromosomal translocation t (X;18)(p11.2; q11.2). Studies have shown that SS is a malignant tumor
Yan Qi, Shuang-Shuang Dong, Yong-Lai He, Zi-Han Liu, Ya-Lan Huang, Ning Wang, Zhen Zhang, Zhong Li, Mei Er Tu He Ta Mi Shi, Xiao Feng, Qing Yao, Hong Zou, Jian-Ming Hu, Li-Juan Pang, Feng Li   +14 more
doaj   +1 more source

MicroRNAs and Natural Compounds Mediated Regulation of TGF Signaling in Prostate Cancer

Frontiers in Pharmacology, 2021
Prostate cancer (PCa) is with rising incidence in male population globally. It is a complex anomaly orchestrated by a plethora of cellular processes. Transforming growth factor-beta (TGF-β) signaling is one of the key signaling pathways involved in the ...
Zeeshan Javed, Khushbukhat Khan, Amna Rasheed, Haleema Sadia, Shahid Raza, Bahare Salehi, William C. Cho, Javad Sharifi-Rad, Javad Sharifi-Rad, Wojciech Koch, Wirginia Kukula-Koch, Anna Głowniak-Lipa, Paweł Helon   +12 more
doaj   +1 more source

The Effects of Botulinum Toxin A on Collagen Synthesis, Expression of MMP (matrix metalloproteinases)-1,2,9 and TIMP (tissue inhibitors of metalloproteinase)-1 in the Keloid Fibroblasts [PDF]

Archives of Aesthetic Plastic Surgery, 2013
Keloids are characterized by excessive extracelluar matrix (ECM) deposition such as collagen, fibronectin, elastin, and proteoglycans in the dermis. Recently, the use of botulinum toxin A (BTXA) in the treatment of keloids have had good results.
Tai Suk Roh, Jong Won Hong, Won Jai Lee, Han-su Yoo, Dae Hyun Lew, Young Seok Kim   +5 more
doaj   +1 more source

Activin and BMP Signaling Activity Affects Different Aspects of Host Anti-Nematode Immunity in Drosophila melanogaster

Frontiers in Immunology, 2021
The multifaceted functions ranging from cellular and developmental mechanisms to inflammation and immunity have rendered TGF-ß signaling pathways as critical regulators of conserved biological processes.
Yaprak Ozakman, Dhaivat Raval, Ioannis Eleftherianos   +2 more
doaj   +1 more source

SHCBP1 promotes synovial sarcoma cell metastasis via targeting TGF-β1/Smad signaling pathway and is associated with poor prognosis

Journal of Experimental & Clinical Cancer Research, 2017
Background Our previous studies reported that SHC SH2-domain binding protein 1 (SHCBP1) functions as an oncogene via promoting cell proliferations in synovial sarcoma (SS) cells.
Changliang Peng, Hui Zhao, Yan Song, Wei Chen, Xiaoying Wang, Xiaoli Liu, Cheng Zhang, Jie Zhao, Ji Li, Guanghui Cheng, Dongjin Wu, Chunzheng Gao, Xiuwen Wang   +12 more
doaj   +1 more source

Regulation of podocyte survival and endoplasmic reticulum stress by fatty acids and its modification by Stearoyl-CoA desaturases and cyclic AMP [PDF]

, 2011
Podocyte apoptosis is a hallmark in the development and progression of diabetic nephropathy (DN). Several factors of the diabetic milieu are known to induce podocyte apoptosis. Currently, the role of free fatty acids (FFAs) for podocytopathy and podocyte
Sieber, Jonas
core   +1 more source

Role of the mTOR pathway in minor salivary gland changes in Sjogren’s syndrome and systemic sclerosis

Arthritis Research & Therapy, 2018
Background To examine the activity of the mammalian target of rapamycin (mTOR) pathway and its regulators, transforming growth factor (TGF)-β1 and phosphatase and tensin homolog (PTEN), in minor salivary gland biopsies of Sjogren’s syndrome (SS) and ...
Zeki Soypaçacı, Zeynep Zehra Gümüş, Fulya Çakaloğlu, Mustafa Özmen, Dilek Solmaz, Sercan Gücenmez, Önay Gercik, Servet Akar   +7 more
doaj   +1 more source