Results 21 to 30 of about 23,607 (143)

MicroRNAs and Natural Compounds Mediated Regulation of TGF Signaling in Prostate Cancer

Frontiers in Pharmacology, 2021
Prostate cancer (PCa) is with rising incidence in male population globally. It is a complex anomaly orchestrated by a plethora of cellular processes. Transforming growth factor-beta (TGF-β) signaling is one of the key signaling pathways involved in the ...
Zeeshan Javed, Khushbukhat Khan, Amna Rasheed, Haleema Sadia, Shahid Raza, Bahare Salehi, William C. Cho, Javad Sharifi-Rad, Javad Sharifi-Rad, Wojciech Koch, Wirginia Kukula-Koch, Anna Głowniak-Lipa, Paweł Helon   +12 more
doaj   +1 more source

The Effects of Botulinum Toxin A on Collagen Synthesis, Expression of MMP (matrix metalloproteinases)-1,2,9 and TIMP (tissue inhibitors of metalloproteinase)-1 in the Keloid Fibroblasts [PDF]

Archives of Aesthetic Plastic Surgery, 2013
Keloids are characterized by excessive extracelluar matrix (ECM) deposition such as collagen, fibronectin, elastin, and proteoglycans in the dermis. Recently, the use of botulinum toxin A (BTXA) in the treatment of keloids have had good results.
Tai Suk Roh, Jong Won Hong, Won Jai Lee, Han-su Yoo, Dae Hyun Lew, Young Seok Kim   +5 more
doaj   +1 more source

Activin and BMP Signaling Activity Affects Different Aspects of Host Anti-Nematode Immunity in Drosophila melanogaster

Frontiers in Immunology, 2021
The multifaceted functions ranging from cellular and developmental mechanisms to inflammation and immunity have rendered TGF-ß signaling pathways as critical regulators of conserved biological processes.
Yaprak Ozakman, Dhaivat Raval, Ioannis Eleftherianos   +2 more
doaj   +1 more source

SHCBP1 promotes synovial sarcoma cell metastasis via targeting TGF-β1/Smad signaling pathway and is associated with poor prognosis

Journal of Experimental & Clinical Cancer Research, 2017
Background Our previous studies reported that SHC SH2-domain binding protein 1 (SHCBP1) functions as an oncogene via promoting cell proliferations in synovial sarcoma (SS) cells.
Changliang Peng, Hui Zhao, Yan Song, Wei Chen, Xiaoying Wang, Xiaoli Liu, Cheng Zhang, Jie Zhao, Ji Li, Guanghui Cheng, Dongjin Wu, Chunzheng Gao, Xiuwen Wang   +12 more
doaj   +1 more source

Role of the mTOR pathway in minor salivary gland changes in Sjogren’s syndrome and systemic sclerosis

Arthritis Research & Therapy, 2018
Background To examine the activity of the mammalian target of rapamycin (mTOR) pathway and its regulators, transforming growth factor (TGF)-β1 and phosphatase and tensin homolog (PTEN), in minor salivary gland biopsies of Sjogren’s syndrome (SS) and ...
Zeki Soypaçacı, Zeynep Zehra Gümüş, Fulya Çakaloğlu, Mustafa Özmen, Dilek Solmaz, Sercan Gücenmez, Önay Gercik, Servet Akar   +7 more
doaj   +1 more source

Sustained hyperosmolarity increses TGF-ß1 and Egr-1 expression in the rat renal medulla

BMC Nephrology, 2017
Background Although TGF-ß and the transcription factor Egr-1 play an important role in both kidney fibrosis and in response to acute changes of renal medullary osmolarity, their role under sustained hypo- or hyperosmolar conditions has not been ...
Miklós M. Mózes, Petra Szoleczky, László Rosivall, Gábor Kökény   +3 more
doaj   +1 more source

Dietary soya saponin improves the lipid metabolism and intestinal health of laying hens

Poultry Science, 2022
: Soya saponin (SS) is a natural active substance of leguminous plant, which could improve lipid metabolism and regulate immune function. Intestinal flora might play a key role in the biological functions of SS. The objective of this study was to measure
Peng Li, Mingkun Gao, Jiahuan Fu, Shaojia Yan, Yongfa Liu, Tahir Mahmood, Zengpeng Lv, Yuming Guo   +7 more
doaj   +1 more source

TGF-β Signaling Interferes With the Drosophila Innate Immune and Metabolic Response to Parasitic Nematode Infection

Frontiers in Physiology, 2019
The common fruit fly, Drosophila melanogaster, is an outstanding model to study the molecular basis of anti-pathogen immunity. The parasitic nematode Heterorhabditis gerrardi, together with its mutualistic bacteria Photorhabdus asymbiotica, infects a ...
Yaprak Ozakman, Ioannis Eleftherianos
doaj   +1 more source

Cardioprotective Peptides from Dry-Cured Ham in Primary Endothelial Cells and Human Plasma: An Omics Approach

Antioxidants
Cardiovascular diseases are a leading cause of mortality, driving the search for alternative preventive strategies. This study investigates the antioxidant effects, among others, of a mixture of four bioactive peptides (BPs) derived from dry-cured pork ...
Clara Noguera-Navarro, Javier Stelling, Esteban Orenes-Piñero, Caterina Pipino, Francisco José Nicolás, Silvia Montoro-García   +5 more
doaj   +1 more source

Egr-1 induces a profibrotic injury/repair gene program associated with systemic sclerosis. [PDF]

PLoS ONE, 2011
Transforming growth factor-ß (TGF-ß) signaling is implicated in the pathogenesis of fibrosis in scleroderma or systemic sclerosis (SSc), but the precise mechanisms are poorly understood. The immediate-early gene Egr-1 is an inducible transcription factor
Swati Bhattacharyya, Jennifer L Sargent, Pan Du, Simon Lin, Warren G Tourtellotte, Kazuhiko Takehara, Michael L Whitfield, John Varga   +7 more
doaj   +1 more source