IL23 and TGF-ß diminish macrophage associated metastasis in pancreatic carcinoma [PDF]
Scientific Reports, 2018 The precise role of tumor associated macrophages remains unclear in pancreatic ductal adenocarcinoma (PDAC) while TGF-ß has an unclear role in metastases formation.
S. Mazher Hussain +12 more
doaj +3 more sources
Prg4 prevents osteoarthritis induced by dominant-negative interference of TGF-ß signaling in mice. [PDF]
PLoS ONE, 2019 ObjectivePrg4, also known as Lubricin, acts as a joint/boundary lubricant. Prg4 has been used to prevent surgically induced osteoarthritis (OA) in mice.
Robert Dalton Chavez +2 more
doaj +3 more sources
TGF-ß Regulates Cathepsin Activation during Normal and Pathogenic Development [PDF]
Cell Reports, 2018 Summary: Cysteine cathepsins play roles during development and disease beyond their function in lysosomal protein turnover. Here, we leverage a fluorescent activity-based probe (ABP), BMV109, to track cysteine cathepsins in normal and diseased zebrafish ...
Heather Flanagan-Steet +8 more
doaj +3 more sources
NANOS1 restricts oral cancer cell motility and TGF-ß signaling [PDF]
European Journal of Cell BiologyOral squamous cell carcinoma (OSCC) is the most frequent type of cancer of the head and neck area accounting for approx. 377,000 new cancer cases every year.
Julia Rosemann +7 more
doaj +3 more sources
Overexpression of T-bet, GATA-3 and TGF-ß Induces IFN-γ, IL-4/13A, and IL-17A Expression in Atlantic Salmon [PDF]
Biology, 2020 The overexpression of GATA-3, T-bet and TGF-ß may theoretically induce IL-4/A, IFN-γ and IL-17A expression, respectively. Whether this also applies to fish is not yet known.
Tiril H. Slettjord +6 more
doaj +2 more sources
TGF-ß induces miR-100 and miR-125b but blocks let-7a through LIN28B controlling PDAC progression. [PDF]
, 2018 TGF-ß/Activin induces epithelial-to-mesenchymal transition (EMT) and stemness in pancreatic ductal adenocarcinoma (PDAC). However, the microRNAs (miRNAs) regulated during this response have remained yet undetermined.
Jonathan Krell (181848) +17 more
core +2 more sources
Clinical and Translational Medicine, 2022 Background Cancer is the world's second leading cause of death, but a significant advancement in cancer treatment has been achieved within the last few decades. However, major adverse effects and drug resistance associated with standard chemotherapy have
Devesh Tewari +3 more
doaj +1 more source
Effect of aging and dietary salt and potassium intake on endothelial PTEN (Phosphatase and tensin homolog on chromosome 10) function. [PDF]
PLoS ONE, 2012 Aging promotes endothelial dysfunction, defined as a reduction in bioavailable nitric oxide (NO) produced by the endothelial isoform of nitric oxide synthase (NOS3).
Wei-Zhong Ying +2 more
doaj +1 more source
PPARγ downregulation by TGFß in fibroblast and impaired expression and function in systemic sclerosis: a novel mechanism for progressive fibrogenesis. [PDF]
PLoS ONE, 2010 The nuclear orphan receptor peroxisome proliferator-activated receptor-gamma (PPAR-γ) is expressed in multiple cell types in addition to adipocytes. Upon its activation by natural ligands such as fatty acids and eicosanoids, or by synthetic agonists such
Jun Wei +9 more
doaj +1 more source
BMC Cancer, 2022 Background Synovial sarcoma (SS) is a type of soft tissue sarcoma (STS) of undetermined tissue origin, which is characterized by the recurrent pathognomonic chromosomal translocation t (X;18)(p11.2; q11.2). Studies have shown that SS is a malignant tumor
Yan Qi +14 more
doaj +1 more source