Results 51 to 60 of about 23,607 (143)

Transforming growth factor β1 inhibition protects from noise-induced hearing loss

Frontiers in Aging Neuroscience, 2015
Excessive exposure to noise damages the principal cochlear structures leading to hearing impairment. Inflammatory and immune responses are central mechanisms in cochlear defensive response to noise but, if unregulated, they contribute to inner ear damage
Silvia eMurillo-Cuesta, Silvia eMurillo-Cuesta, Silvia eMurillo-Cuesta, Lourdes eRodríguez-de La Rosa, Lourdes eRodríguez-de La Rosa, Lourdes eRodríguez-de La Rosa, Julio eContreras, Julio eContreras, Julio eContreras, Adelaida M Celaya, Adelaida M Celaya, Guadalupe eCamarero, Guadalupe eCamarero, Guadalupe eCamarero, Teresa eRivera, Teresa eRivera, Teresa eRivera, Isabel eVarela-Nieto, Isabel eVarela-Nieto, Isabel eVarela-Nieto   +19 more
doaj   +1 more source

Canagliflozin and irbesartan ameliorate renal fibrosis via the TGF-β1/Smad signaling pathway in Dahl salt-sensitive rats

Journal of International Medical Research, 2023
Objectives This study assessed the antifibrotic effects of canagliflozin, with or without irbesartan, on renal injury in Dahl salt-sensitive (SS) rats fed a high-salt (HS) diet.
Jianlong Zhai, Zhongli Wang, Tingting Zhang, Lili He, Sai Ma, Qingjuan Zuo, Guorui Zhang, Xinyu Wang, Yifang Guo   +8 more
doaj   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Effects of cold atmospheric plasma (CAP) on ß-defensins, inflammatory cytokines, and apoptosis-related molecules in keratinocytes in vitro and in vivo. [PDF]

PLoS ONE, 2015
Cold atmospheric plasma (CAP) has been gaining increasing interest as a new approach for the treatment of skin diseases or wounds. Although this approach has demonstrated promising antibacterial activity, its exact mechanism of action remains unclear ...
Stephanie Arndt, Michael Landthaler, Julia L Zimmermann, Petra Unger, Eva Wacker, Tetsuji Shimizu, Yang-Fang Li, Gregor E Morfill, Anja-Katrin Bosserhoff, Sigrid Karrer   +9 more
doaj   +1 more source

Periodontitis and Inflammatory Bowel Diseases: Mechanistic Evidence

Journal of Periodontal Research, EarlyView.
This review aims to provide a conceptual framework for understanding the mechanistic interplay between periodontitis and IBD, with a particular emphasis on the microbial and immunological crosstalk linking the oral cavity and the gastrointestinal tract.
Ana Paula V. Colombo, Adriana M. de Oliveira, Nobuhiko Kamada, Sho Kitamoto   +3 more
wiley   +1 more source

From senescence and inflammaging to systemic comorbidities: Drivers of aging‐associated periodontitis

Periodontology 2000, EarlyView.
Abstract Background Aging is accompanied by a chronic low‐grade inflammatory process, known as inflammaging, as well as immunosenescence, an age‐related decline and dysregulation of immune function, and cellular senescence, a process in which cells enter a state of irreversible growth arrest while actively releasing pro‐inflammatory factors.
James Cheng, Chew Tin Zar Aung, Samuel F. Suslavich, Sinem Esra Sahingur, Yvonne L. Hernandez‐Kapila   +4 more
wiley   +1 more source

Transforming growth factor beta activity in urine of patients with type 2 diabetes and diabetic nephropathy

Brazilian Journal of Medical and Biological Research, 1999
Diabetic nephropathy (DN) is characterized structurally by progressive mesangial deposition of extracellular matrix (ECM). Transforming growth factor-ß (TGF-ß) is considered to be one of the major cytokines involved in the regulation of ECM synthesis and
Rivarola E.W.R., Moyses-Neto M., Dantas M., da-Silva C.G., Volpini R., Coimbra T.M.   +5 more
doaj  

Beyond biologic sex: Exploratory insights into the heterogeneity of hormonal and contextual drivers of periodontal and peri‐implant outcomes

Periodontology 2000, EarlyView.
Abstract Background Periodontal and peri‐implant diseases are multifactorial inflammatory conditions influenced by microbial, host, hormonal, genetic, and behavioral factors. Although sex‐based differences in immune and inflammatory responses are well recognized in medicine, the extent to which biologic sex and hormonal status influence the prevalence,
Caitlin Neapole, Mark Gettas, Roberto Farina, Yvonne Hernandez‐Kapila   +3 more
wiley   +1 more source

Dynamic Granulocyte Turnover Inferred From cfDNA Methylation Predicts Immunotherapy Benefit in Liver‐Metastatic Small Cell Lung Cancer: A Prospective Biomarker Study

MedComm, Volume 7, Issue 9, September 2026.
This prospective study evaluated envafolimab plus chemotherapy in 29 SCLC patients with liver metastases, integrating multi‐omics analyses (WES, RNA‐seq, DNA methylation, ctDNA, and cfDNA methylation). The research framework encompassed granulocyte turnover dynamics, prognostic risk modeling, molecular mechanism exploration across risk strata, and ...
Ning Tang, Xiaoling Shang, Yulan Sun, Yingqian Zhang, Haiyan Zhou, Shucheng Ye, Xiaoyong Tang, Jun Guo, Xiqin Zhang, Xuan Gao, Zhehai Wang, Haiyong Wang   +11 more
wiley   +1 more source

Nanoparticle‐Mediated Therapy for Glioma: Advances and Prospects

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Various nanocarriers, including liposomes, dendrimers, exosomes and gold nanoparticles, are designed to penetrate the blood‐brain barrier and deliver chemotherapy, radiotherapy, immunotherapy, gene therapy, phototherapy, magnetic hyperthermia and sonodynamic therapy for glioma.
Wenqian Jiang, Jing Fei, Rangrang Fan, Haifeng Chen, Liangxue Zhou, Gang Guo   +5 more
wiley   +1 more source