Transforming growth factor-β: A therapeutic target for cancer
Human Vaccines & Immunotherapeutics, 2017 Transforming growth factor-β (TGF-β) regulates cell growth and differentiation, apoptosis, cell motility, extracellular matrix production, angiogenesis, and cellular immunity. It has a paradoxical role in cancer.
Sulsal Haque, John C. Morris
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Analysis of the effects of five factors relevant to in vitro chondrogenesis of human mesenchymal stem cells using factorial design and high throughput mRNA-profiling. [PDF]
PLoS ONE, 2014 The in vitro process of chondrogenic differentiation of mesenchymal stem cells for tissue engineering has been shown to require three-dimensional culture along with the addition of differentiation factors to the culture medium.
Rune B Jakobsen +4 more
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Transforming Growth Factor‐β Pathway: Biological Functions and Therapeutic Targets [PDF]
MedCommCancer progression is often driven by aberrant cell growth and genetic mutations, leading to metastasis. The transforming growth factor‐beta (TGF‐β) pathway, a key regulator of cellular growth and differentiation, exhibits dual roles in cancer by ...
Reham Hassan Mekky +9 more
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Cell type–dependent role of transforming growth factor-β signaling on postnatal neural stem cell proliferation and migration [PDF]
Neural Regeneration ResearchAdult neurogenesis continuously produces new neurons critical for cognitive plasticity in adult rodents. While it is known transforming growth factor-β signaling is important in embryonic neurogenesis, its role in postnatal neurogenesis remains unclear ...
Kierra Ware +3 more
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Molecular Therapy: Nucleic Acids, 2018 Fibrosis is common after skeletal muscle injury, undermining tissue regeneration and function. The mechanism underlying skeletal muscle fibrosis remains unveiled.
Yaying Sun +5 more
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Transforming growth factor-β receptors: versatile mechanisms of ligand activation. [PDF]
Acta Pharmacol SinTransforming growth factor-β (TGF-β) signaling is initiated by activation of transmembrane TGF-β receptors (TGFBR), which deploys Smad2/3 transcription factors to control cellular responses.
Chia ZJ, Cao YN, Little PJ, Kamato D.
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Role of transforming growth factor-β in peripheral nerve regeneration [PDF]
Neural Regeneration ResearchInjuries caused by trauma and neurodegenerative diseases can damage the peripheral nervous system and cause functional deficits. Unlike in the central nervous system, damaged axons in peripheral nerves can be induced to regenerate in response to ...
Zihan Ding +6 more
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β-Sitosterol Inhibits The Proliferation of Endometrial Cells via Regulating Smad7-Mediated TGF-β/Smads Signaling Pathway [PDF]
Cell Journal, 2023 Objective: To investigate the effect of β-sitosterol on endometrial cells to understand the underlying mechanism.Materials and Methods: This is a laboratory-based experimental study conducted on animals and cells.
Yi Wen +6 more
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Transforming Growth Factor (TGF) β and Endometrial Vascular Maturation
Frontiers in Cell and Developmental Biology, 2021 Appropriate growth and development of the endometrium across the menstrual cycle is key for a woman’s quality of life and reproductive well-being. Recurrent pregnancy loss (RPL) and heavy menstrual bleeding (HMB) affect a significant proportion of the ...
Qinsheng Lu +7 more
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Transforming growth factor-β in tumour development
Frontiers in Molecular Biosciences, 2022 Transforming growth factor-β (TGFβ) is a ubiquitous cytokine essential for embryonic development and postnatal tissue homeostasis. TGFβ signalling regulates several biological processes including cell growth, proliferation, apoptosis, immune function ...
Charles B. Trelford +3 more
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