Results 21 to 30 of about 1,084,742 (347)

Extracellular Vesicles and Transforming Growth Factor β Signaling in Cancer

Frontiers in Cell and Developmental Biology, 2022
Complexity in mechanisms that drive cancer development and progression is exemplified by the transforming growth factor β (TGF-β) signaling pathway, which suppresses early-stage hyperplasia, yet assists aggressive tumors to achieve metastasis.
Dorival Mendes Rodrigues-Junior, Chrysoula Tsirigoti, Sai Kiang Lim, Carl-Henrik Heldin, Aristidis Moustakas   +4 more
doaj   +1 more source

THU0271 SERUM LEVELS OF TRANSFORMING GROWTH FACTOR î‘ (TGF-î‘) IN PATIENTS WITH PRIMARY SJÖGREN'S SYNDROME [PDF]

Annals of the Rheumatic Diseases, 2019
Background Primary Sjogren’s syndrome (pSS) is an autoimmune disease affecting primarily exocrine, especially salivary, glands. The epithelial damage, autoantigens release, activation of innate and acquired immunity form the underlaying of the pSS pathogenesis. The main role in pSS is played by B-lymphocytes and production of autoantibodies.
Maria Maślińska, Agnieszka Paradowska-Gorycka, Małgorzata Mańczak, Kinga Kostyra-Grabczak, Brygida Kwiatkowska   +4 more
openaire   +1 more source

Regulation of transforming growth factor-β signalling by SUMOylation and its role in fibrosis

Open Biology, 2021
Fibrosis is an abnormal healing process that only repairs the structure of an organ after injury and does not address damaged functions. The pathogenesis of fibrosis is multifactorial and highly complex; numerous signalling pathways are involved in this ...
Xinyi Wang, Ting Liu, Yifei Huang, Yifeng Dai, Hui Lin   +4 more
doaj   +1 more source

Transforming growth factor-β signalling pathway in tendon healing

Growth Factors, 2022
Transforming growth factor-β(TGF-β) plays an important but diverse role in tendon injuries, such as collagen synthesis, cell proliferation, cell differentiation, and cell adhesion, leading to tendon healing and tendon fibrosis.
Yujie Li, Xinyue Liu, Xueli Liu, Yuanqiu Peng, Bin Zhu, Sheng Guo, Chenglong Wang, Dingxuan Wang, Sen Li   +8 more
semanticscholar   +1 more source

Transforming growth factor–β in tissue fibrosis

Journal of Experimental Medicine, 2020
TGF-β is a central mediator in the fibrotic response. This review discusses the role of TGF-β in tissue fibrosis, highlighting the mechanisms of TGF-β activation and signaling, the cellular targets of TGF-β actions, and the challenges of therapeutic ...
N. Frangogiannis
semanticscholar   +1 more source

TGF-β regulates nerve growth factor expression in a mouse intervertebral disc injury model

BMC Musculoskeletal Disorders, 2021
Background Intervertebral disc (IVD) degeneration is a major cause of low back pain (LBP). Following disc injury, nerve growth factor (NGF) concentrations rise in IVDs, and anti-NGF therapy has been shown to attenuate LBP in humans.
Yuji Yokozeki, Kentaro Uchida, Ayumu Kawakubo, Mitsufumi Nakawaki, Tadashi Okubo, Masayuki Miyagi, Gen Inoue, Makoto Itakura, Hiroyuki Sekiguchi, Masashi Takaso   +9 more
doaj   +1 more source

Correlation of Expression Transforming Growth Factor-β1, E-cadherin, and Ki-67 in Meningiomas

Open Access Macedonian Journal of Medical Sciences, 2020
BACKGROUND: Meningioma is the most common primary intracranial tumors in adults, accounts for 36% of total intracranial tumors. Obtaining the clinicopathological characteristics of patients with meningioma and investigating, the association between signaling pathways with disease progression could provide a basis for therapeutic development.AIM: This ...
Apriyanto Apriyanto, Eryati Darwin, Muhammad Z. Arifin, Wirsma A. Harahap   +3 more
openaire   +1 more source

Transforming growth factor β signaling overcomes dasatinib resistance in lung cancer. [PDF]

PLoS ONE, 2014
Lung cancer is the second most common cancer and the leading cause of cancer-related deaths. Despite recent advances in the development of targeted therapies, patients with advanced disease remain incurable, mostly because metastatic non-small cell lung ...
Edna Gordian, Jiannong Li, Yuri Pevzner, Melanie Mediavilla-Varela, Kimberly Luddy, Kim Ohaegbulam, Kenyon G Daniel, Eric B Haura, Teresita Muñoz-Antonia   +8 more
doaj   +1 more source

Regulation of the transforming growth factor β pathway by reversible ubiquitylation [PDF]

Open Biology, 2012
The transforming growth factor β (TGFβ) signalling pathway plays a central role during embryonic development and in adult tissue homeostasis. It regulates gene transcription through a signalling cascade from cell surface receptors to intracellular SMAD ...
Mazin A. Al-Salihi, Lina Herhaus, Gopal P. Sapkota   +2 more
doaj   +1 more source

Expression of epidermal growth factor and transforming growth factor α in interfacial membranes retrieved at revision total hip arthroplasty [PDF]

Annals of the Rheumatic Diseases, 2000
The interfacial membrane between bone and implant has been shown to be a key tissue in the process of aseptic loosening of total hip arthroplasty. The cells within the interfacial membrane produce numerous inflammatory mediators which, through complex mechanisms, cause periprosthetic osteolysis and aseptic loosening.
J W, Xu, J, Ma, T F, Li, E, Waris, A, Alberty, S, Santavirta, Y T, Konttinen   +6 more
openaire   +2 more sources