Results 31 to 40 of about 1,084,742 (347)
Journal of Experimental Medicine, 2001 CD4+CD25+ T cells have been identified as a population of immunoregulatory T cells, which mediate suppression of CD4+CD25− T cells by cell–cell contact and not secretion of suppressor cytokines.
Kazuhiko Nakamura, A. Kitani, W. Strober
semanticscholar +1 more source
Effect on the canine Eck fistula liver of intraportal TGF‐β alone or with hepatic growth factors [PDF]
, 1992 Transforming growth factor‐β canceled the hepatocyte proliferation caused by transforming growth factor‐α when the two substances were mixed and administered through a disconnected central portal vein branch after creation of an Eck fistula. In contrast,
Alessandro Azzarone +28 more
core +1 more source
Transforming Growth Factor-β Signaling in Immunity and Cancer.
Immunity, 2019 Transforming growth factor (TGF)-β is a crucial enforcer of immune homeostasis and tolerance, inhibiting the expansion and function of many components of the immune system. Perturbations in TGF-β signaling underlie inflammatory diseases and promote tumor
E. Batlle, J. Massagué
semanticscholar +1 more source
Transforming Growth Factor-β Signaling in Fibrotic Diseases and Cancer-Associated Fibroblasts
Biomolecules, 2020 Transforming growth factor-β (TGF-β) signaling is essential in embryo development and maintaining normal homeostasis. Extensive evidence shows that TGF-β activation acts on several cell types, including epithelial cells, fibroblasts, and immune cells, to
Xueke Shi +3 more
semanticscholar +1 more source
Polymorphism in TGFB1 is associated with worse non-relapse mortality and overall survival after stem cell transplantation with unrelated donors. [PDF]
, 2015 Transforming growth factor beta-1, encoded by the TGFB1 gene, is a cytokine that plays a central role in many physiological and pathogenic processes.
Apperley, JF +13 more
core +2 more sources
Transforming growth factor-β in diabetic nephropathy
The Egyptian Journal of Internal Medicine, 2013 Background Renal failure is a common and serious complication of long-standing diabetes mellitus. Diabetes is the most common cause of end-stage renal failure.
Karima Y. Ahmed +3 more
doaj +1 more source
Targeting transforming growth factor-β receptors in pulmonary hypertension
European Respiratory Journal, 2020 The transforming growth factor-β (TGF-β) superfamily includes several groups of multifunctional proteins that form two major branches, namely the TGF-β–activin–nodal branch and the bone morphogenetic protein (BMP)–growth differentiation factor (GDF ...
C. Guignabert, M. Humbert
semanticscholar +1 more source
Smad2-dependent glycosaminoglycan elongation in aortic valve interstitial cells enhances binding of LDL to proteoglycans [PDF]
, 2013 Calcific aortic valve disease is a progressive condition that shares some common pathogenic features with atherosclerosis. Transforming growth factor-ß1 is a recognized mediator of atherosclerosis and is expressed in aortic valve lesions.
Ballinger, M +6 more
core +1 more source
BMC Cell Biology, 2009 Background β-catenin and transforming growth factor β signaling are activated in fibroblasts during wound healing. Both signaling pathways positively regulate fibroblast proliferation during this reparative process, and the effect of transforming growth ...
Slade Laura +4 more
doaj +1 more source
Transforming growth factor β1 inhibition protects from noise-induced hearing loss [PDF]
Frontiers in Aging Neuroscience, 2015 Excessive exposure to noise damages the principal cochlear structures leading to hearing impairment. Inflammatory and immune responses are central mechanisms in cochlear defensive response to noise but, if unregulated, they contribute to inner ear damage and hearing loss.
Silvia eMurillo-Cuesta +19 more
openaire +5 more sources