Results 161 to 170 of about 142,802 (274)

Transcription Factor Forkhead Box O1 Mediates Transforming Growth Factor-β1-Induced Apoptosis in Hepatocytes. [PDF]

Am J Pathol, 2023
Chen Y, Pan Q, Liao W, Ai W, Yang S, Guo S.   +5 more
europepmc   +1 more source

PSMA8‐Containing 20S Proteasome Regulates Spermiogenesis and Male Fertility

Advanced Science, EarlyView.
PSMA8 assembles s20S proteasome that degrades specific substrates in elongating spermatids. Degradation of s20S‐substrates activates translation of FXR1‐target mRNAs, which are essential for mitochondrial sheath formation and sperm morphogenesis.
Huiwen Cao, Qianting Zhang, Wei Xu, Anxuan Fang, Haomang Xu, Cheng Qiu, Lugeng He, Chao Yu   +7 more
wiley   +1 more source

Platelet-Derived Transforming Growth Factor-β1: A New Hope for Cerebral Malaria Treatment. [PDF]

ACS Infect Dis
Liu S, Guo B, Song L, Chen G, Zhang T, Du Y.   +5 more
europepmc   +1 more source

[Retracted] Inhibition airway remodeling and transforming growth factor‑β1/Smad signaling pathway by astragalus extract in asthmatic mice. [PDF]

Int J Mol Med, 2023
Qu ZH, Yang ZC, Chen L, Lv ZD, Yi MJ, Ran N.   +5 more
europepmc   +1 more source

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

Proximal aortic aneurysms in mice underexpressing transforming growth factor-β1. [PDF]

J Physiol Sci
Kakoki M, Hagaman JR, Terajima M, Nagasawa M, Uoshima K, Yamauchi M, Smithies O, Kansaku K.   +7 more
europepmc   +1 more source

AML‐Targeted Metal‐Polyphenol Nanoplatform Induces Ferroptosis‐ICD Cascade for Antitumor Immunity Boosting

Advanced Science, EarlyView.
Schematic illustration of the synthesis protocol for Fe‐SH@Fn, an AML‐targeted nanoplatform engineered to co‐deliver shikonin (SH) and Fe3+, synergistically boosting antitumor immunity via ferroptosis induction and immunogenic cell death (ICD). ABSTRACT Acute myeloid leukemia (AML) remains a therapeutic challenge due to its low immunogenicity and ...
Shangqin Yang, Jingxuan Wang, Kerong Tu, Xiaobing Huang, Liangliang Lv, Mingjie Peng, Qiqi Xu, Hongmei Liu, Qiang Sun, Lulu Cai   +9 more
wiley   +1 more source

Transcriptome analysis of chicken fibroblast following transforming growth factor β1-mediated activation. [PDF]

Poult Sci
Hou T, Zhang L, Zhao L, Gao F, Xing T.
europepmc   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Silencing Rac1 and Prex1 Inhibit Epithelial-Mesenchymal Transition in Human Gastric Cancer Cells Induced by Transforming Growth Factor-β1. [PDF]

Turk J Gastroenterol, 2023
Gao X, Lin X, Lin M, Lan Y, Wang Y, Wu R, Li J, Huang C, Zhong D.   +8 more
europepmc   +1 more source