Results 111 to 120 of about 523,619 (399)

Transforming growth factor beta 1 induces methylation changes in lung fibroblasts.

PLoS ONE, 2019
Idiopathic pulmonary fibrosis is a complex disease of unknown etiology. Environmental factors can affect disease susceptibility via epigenetic effects. Few studies explore global DNA methylation in lung fibroblasts, but none have focused on transforming ...
Miguel Negreros, James S Hagood, Celia R Espinoza, Yalbi I Balderas-Martínez, Moisés Selman, Annie Pardo   +5 more
doaj   +1 more source

Elevated expression of type VII collagen in the skin of patients with systemic sclerosis. Regulation by transforming growth factor-beta. [PDF]

, 1994
A hallmark of systemic sclerosis (SSc) is the development of tissue fibrosis. Excessive production of several connective tissue components normally present in the dermis, including type I, III, V, and VI collagens as well as fibronectin and proteoglycans,
Christiano, Angela M., Iozzo, Renato V., Jimenez, Sergio A., Rudnicka, Lidia, Uitto, Jouni, Varga, John   +5 more
core   +3 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Decitabine reverses TGF-β1-induced epithelial–mesenchymal transition in non-small-cell lung cancer by regulating miR-200/ZEB axis [Corrigendum]

Drug Design, Development and Therapy, 2017
Zhang N, Liu Y, Wang Y, Zhao M, Tu L, Luo F. Drug Des Devel Ther. 2017;11:969–983.Throughout the paper, including Figures, an abbreviation has been defined incorrectly.
Zhang N, Liu Y, Wang Y, Zhao M, Tu L, Luo F   +5 more
doaj  

Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor beta

Journal of Experimental Medicine, 1993
Activated mouse peritoneal macrophages produce nitric oxide (NO) via a nitric oxide synthase that is inducible by interferon gamma (IFN- gamma): iNOS.
Y. Vodovotz, C. Bogdan, J. Paik, Q. Xie, C. Nathan   +4 more
semanticscholar   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Effects of Aqueous Extract of Trachyspermum Copticum (L.) link Seeds on Transcription of Transforming Growth Factor-beta Receptor 1 and 2 Genes in Cancer Cells

مجله دانشکده پزشکی اصفهان, 2017
Background: Transforming growth factor (TGF)-beta 2 signaling pathways and their receptors exert a pivotal role in behavior and fate of tumor cells. Therefore, these pathways are target of drug discovery researches.
Marzieh Alikhani, Forouzan Karimi, Hassan Darbandi-Tamijani, Sarira Shahnavaz, Shima Rasouli, Mohammad Kamalinejad, Ahad Khalilnejad, Mohammad-Reza Sohrabi   +7 more
doaj  

Transforming growth factor-beta in systemic sclerosis scleroderma

Frontiers in Bioscience, 2009
Deregulated transforming growth factor-beta (TGF-beta) activity and responses play prominent roles in the pathogenesis of systemic sclerosis (SSc), a chronic and progressive connective tissue disease characterized by fibrosis of the skin and internal organs.
John, Varga, Michael L, Whitfield
openaire   +2 more sources

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Transforming growth factor-β1 gene polymorphism in psoriasis vulgaris

Clinical, Cosmetic and Investigational Dermatology, 2018
Heba H El-hadidi,1 Akmal S Hassan,1 Ghada El-hanafy,1 Khalda S Amr,2 Sameh F Abdelmesih,3 Mahmoud F Abdelhamid3 1Department of Dermatology, Kasr Al-Ainy University Hospitals, Cairo University, Giza, Egypt; 2Department of Molecular Genetics, National ...
El-hadidi HH, Hassan AS, El-hanafy G, Amr KS, Abdelmesih SF, Abdelhamid MF   +5 more
doaj