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Transforming Growth Factor Beta in Pancreatic Cancer
Current Pharmaceutical Biotechnology, 2011Pancreatic cancer has high incidence and mortality rates, and effective treatment remains a clinical challenge. As deregulation of the cytokine transforming growth factor beta (TGF-β) contributes to the progression of pancreatic carcinoma, the TGF-β pathway has been targeted using various strategies, including small molecule inhibitors of TGF-βRI, TGF ...
Andreas, Hilbig, Helmut, Oettle
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What is transforming growth factor-beta (TGF-β)?
British Journal of Plastic Surgery, 2004The TGF-beta superfamily of proteins produces a wide range of frequently opposing effects in different cells and tissues in the body. However, its activation and mode of action are only partially understood because of its complexity in structure and functions and the variability in its downstream targets.
Chin, David +3 more
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Transforming Growth Factor Beta in Fracture Repair
Clinical Orthopaedics and Related Research, 1998Transforming growth factor betas are a group of polypeptide growth factors that have a wide range of activities in the musculoskeletal and immunological systems. They are thought to play an important role in the development, induction, and repair of bone.
M P, Bostrom, P, Asnis
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Transforming growth factor beta: Relevance to radiotherapy
Clinical Oncology, 1995supporting evidence, both from animal work and from clinical findings, to implicate TGFfi in the pathogenesis of radiofibrosis. Animal studies have shown an association between TGFfi levels and radiation fibrosis. In rat liver, the percentage of hepatocytes staining strongly positive for TGFfi after radiation correlates with the extent of subsequent ...
C C, Parker, J R, Yarnold
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Transforming growth factor-beta.
Cancer surveys, 1992This chapter has described some of the most salient features of the biology of the TGF-beta s. The TGF-beta s are of great interest as growth inhibitors, regulators of cell phenotype and regulators of cell adhesion. The various TGF-beta isoforms are highly conserved and display a complex pattern of interactions with multiple membrane receptor ...
J, Massagué +5 more
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Transforming growth factor betas in mammalian embryogenesis
Progress in Growth Factor Research, 1990Type beta transforming growth factors (TGF beta s) are members of a large superfamily of related proteins, each of which plays a pivotal role in embryonic processes. The TGF beta s per se are at least five in number, though only three isoforms have been identified in mammals.
Akhurst, Rosemary J. +4 more
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Transforming growth factor beta and the endometrium
Reviews of Reproduction, 1998During the oestrous or menstrual cycle and throughout much of pregnancy, the uterine endometrium undergoes rapid, as well as progressive, morphological and functional modification. During the preimplantation stage of pregnancy, the endometrium provides an environment that sustains embryonic development, and then participates in the nidation process ...
J D, Godkin, J J, Doré
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Urology, 2008
The mouse renal cell carcinoma line, Renca, is insensitive to transforming growth factor-beta (TGF-beta) in vitro. The present study was conducted to determine whether removal of TGF-beta from these tumor cells would inhibit tumor progression in vivo.TGF-beta elimination was accomplished either by administration of neutralizing TGF-beta antibody into ...
Kent, Perry +11 more
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The mouse renal cell carcinoma line, Renca, is insensitive to transforming growth factor-beta (TGF-beta) in vitro. The present study was conducted to determine whether removal of TGF-beta from these tumor cells would inhibit tumor progression in vivo.TGF-beta elimination was accomplished either by administration of neutralizing TGF-beta antibody into ...
Kent, Perry +11 more
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The Journal of Immunology, 1991
Abstract Participation of human polymorphonuclear neutrophils in the inflammatory response is mediated, in part, by soluble factors such as chemotactic peptides and cytokines. Although the cytokine, transforming growth factor beta (TGF-beta), has been shown to recruit monocytes and promote the inflammatory process, its effects on ...
M E, Brandes +3 more
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Abstract Participation of human polymorphonuclear neutrophils in the inflammatory response is mediated, in part, by soluble factors such as chemotactic peptides and cytokines. Although the cytokine, transforming growth factor beta (TGF-beta), has been shown to recruit monocytes and promote the inflammatory process, its effects on ...
M E, Brandes +3 more
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Transforming growth factor-beta (TGF-beta).
The international journal of biochemistry & cell biology, 1998The TGF-beta family of cytokines are ubiquitous, multifunctional and essential to survival. They play important roles in growth and development, inflammation and repair and host immunity. The mammalian TGF-beta isoforms (TGF-beta 1, beta 2 and beta 3) are secreted as latent precursors and have multiple cell surface receptors of which at least two ...
D A, Clark, R, Coker
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