Results 41 to 50 of about 53,894 (256)
Epigenetic inheritance. Concepts, mechanisms and perspectives [PDF]
, 2018 Parents' stressful experiences can influence an offspring's vulnerability to many pathological conditions, including psychopathologies, and their effects may even endure for several generations.
Lacal, Irene, Ventura, Rossella
core +1 more source
Allostatic load and preterm birth [PDF]
, 2015 Preterm birth is a universal health problem that is one of the largest unmet medical needs contributing to the global burden of disease. Adding to its complexity is that there are no means to predict who is at risk when pregnancy begins or when women ...
McCreary, J Keiko +5 more
core +3 more sources
The Extended (Evolutionary) Synthesis Debate: Where Science Meets Philosophy [PDF]
, 2014 Recent debates between proponents of the modern evolutionary synthesis (the standard model in evolutionary biology) and those of a possible extended synthesis are a good example of the fascinating tangle among empirical, theoretical, and conceptual or ...
Finkelman, Leonard, Pigliucci, Massimo
core +2 more sources
Advanced Healthcare Materials, EarlyView.This study develops a placenta‐targeted nanodelivery system co‐loading HMGB1 protein and the NLRP3 agonist nigericin to establish an animal model of atonic postpartum hemorrhage. The model accurately recapitulates clinical phenotypes, including prolonged labor and uterine contractility dysfunction, while revealing inflammatory activation in placental ...
Jiangxue Qu +10 more
wiley +1 more source
Indelible Race Memories and Subliminal Epigenetics in Octavia Butler’s Kindred [PDF]
Intersections, 2018 Octavia E. Butler’s Kindred highlights complexities beyond those related to a tale of time-travel and a painful slave narrative. It allows us to reimagine definitions of “race memory” and “trauma” along the lines of genetic ancestry that is explored ...
Dutta, Suchismita
doaj
Challenges, 2018 Intrauterine and early life has been accepted as important susceptibility windows for environmental exposure and disease later in life. Emerging evidence suggests that exposure before conception may also influence health in future generations.
Marianne Lønnebotn +6 more
doaj +1 more source
Transgenerational latent early-life associated regulation unites environment and genetics across generations [PDF]
, 2016 The origin of idiopathic diseases is still poorly understood. The latent early-life associated regulation (LEARn) model unites environmental exposures and gene expression while providing a mechanistic underpinning for later-occurring disorders.
Bayon, Baindu L. +6 more
core +1 more source
Advanced Healthcare Materials, EarlyView.This review explores how alternative invertebrate and small‐vertebrate models advance the evaluation of nanomaterials across medicine and environmental science. By bridging cellular and organismal levels, these models enable integrated assessment of toxicity, biodistribution, and therapeutic performance.
Marie Celine Lefevre +3 more
wiley +1 more source
Advanced Science, EarlyView.This study suggests that prenatal aspirin exposure is associated with reduced ovarian reserve in offspring, associated with HDAC1‐linked epigenetic downregulation of Usp9x as a candidate mechanism. These preclinical findings provide new insights into fetal‐origin ovarian disorders and contribute to the evidence base concerning aspirin's gestational ...
Yating Li +11 more
wiley +1 more source
Frontiers in Plant Science, 2015 The transgenerational inheritance of stress-induced epigenetic modifications is still controversial. Despite several examples of defence ‘priming’ and induced genetic rearrangements, the involvement and persistence of transgenerational epigenetic ...
Penny J Tricker
doaj +1 more source