Results 91 to 100 of about 80,448 (304)
Small RNA interactions with transgenes in genetically modified mosquito lines
, 2023 Data management plan for the grant, "Small RNA interactions with transgenes in genetically modified mosquito lines.
Macias, Vanessa Michelle, 1986-
core
Advanced Science, EarlyView.Magnetomechanical neuromodulation using magnetic nanodiscs enables remote activation of neurons. In a hemiparkinsonian mouse model, alternating magnetic fields actuate the nanodiscs to generate torque that opens mechanosensitive ion channels within the subthalamic nucleus, thereby modulating basal ganglia motor circuitry.
Anouk Wolters +12 more
wiley +1 more source
RDR2 partially antagonizes the production of RDR6-dependent siRNA in sense transgene-mediated PTGS.
PLoS ONE, 2012 BackgroundRNA-DEPENDENT RNA POLYMERASE6 (RDR6) and SUPPRESSOR of GENE SILENCING 3 (SGS3) are required for DNA methylation and post-transcriptional gene silencing (PTGS) mediated by 21-nt siRNAs produced by sense transgenes (S-PTGS).
Vincent Jauvion +4 more
doaj +1 more source
Modified genomic transgenes to assess individual miR-279/996 functions.
, 2015 (A) In the 16.6kb mir-279/996 rescue transgene, the 5' end extends to cover a portion of the upstream CG14508 gene and 3' end extends into the downstream Ef1gamma gene. Green and blue triangles represent mir-279 and mir-996 hairpins, respectively.
Eric C. Lai (184436) +4 more
core +1 more source
Advanced Science, EarlyView.Schematic representation of the role of lipophagy in bone mesenchymal stem cells(MSCs). In healthy MSCs, functional lipophagy efficiently degrades lipid droplets to support oxidative phosphorylation and cellular energy production, thereby facilitating osteogenic differentiation and matrix mineralization.
Chaoqiang Chen +8 more
wiley +1 more source
Journal of Andrology, 1997 There are numerous tools available to modify the genetic makeup of animals. They are being used to good advantage for studying basic biological phenomena. Within the decade, biomedical products derived from transgenic animals will be available, but the use of this technology for enhancing the quality and efficiency of livestock production will await ...
Wall, R. J. +4 more
openaire +4 more sources
Rescue Expression of dSarm1 transgenes rescue lethality of dSarm1 mutants.
, 2022 Daughterless-GAL4 (da-GAL4) was used to drive ubiquitous expression of Sarm1 transgenes. Homozygous dSarm14705/dSarm14621 mutant animals are lethal. Expression of transgenes in the mutant background tests for the ability of the transgene to rescue dSarm1
Jeff Milbrandt (12915261) +6 more
core +1 more source
Boosting Sensory Nerve‐to‐Bone Interactions Enhances Hedgehog Mediated Calvarial Bone Repair
Advanced Science, EarlyView.Boosting sensory nerve activity via TrkA agonism strongly accelerates calvarial bone repair in adult mice. Furthermore, single‐cell RNA sequencing and neuron–bone interactome analyses identify these sensory neurons as a direct neural source of Hedgehog pathway ligands. Consequently, these ligands drive osteoblast differentiation of skeletal progenitors,
Zhao Li +9 more
wiley +1 more source
Advanced Science, EarlyView.Engineered extracellular vesicles displaying Ephrin‐B2 selectively target Ephrin‐B4–expressing ovarian cancer cells, enabling precise delivery in patient‐derived models. This scalable bio‐manufacturing platform reveals a versatile strategy to exploit Ephrin signaling for highly specific therapeutic payload delivery and motivates exploration of tailored
Nihar Godbole +17 more
wiley +1 more source
, 2008 Analysis of the transgenic papaya genome sequence suggests that transgenes generally stay put following integration and can achieve stable expression level from generation to generation.
Kohli A, Christou P
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