Results 101 to 110 of about 80,448 (304)

Imaging mouse cancer models in vivo using reporter transgenes

, 2013
Imaging mouse models of cancer with reporter transgenes has become a relatively common experimental approach in the laboratory, which allows noninvasive and longitudinal investigation of diverse aspects of tumor biology in vivo.
Lyons, S. K., Patrick, P. S., Brindle, K. M.   +2 more
core   +1 more source

Genetic Code Expanded T Cell for Controllable Immunotherapy

Advanced Science, EarlyView.
Our GCE‐CAR‐T cells enables tight, dose‐dependent, and function‐preserving control of CAR expression at the translational level through amber codon suppression and genetic incorporation of ncAA. ABSTRACT Chimeric antigen receptor (CAR)‐T cell therapy has demonstrated curative potential against hematologic malignancies, but its clinical application ...
Xue Wang, Yingao Gao, Yeyu Su, Yong Wang, Tao Liu   +4 more
wiley   +1 more source

Multicistronic lentiviral vectors containing the FMDV 2A cleavage factor demonstrate robust expression of encoded genes at limiting MOI

Virology Journal, 2006
Background A number of gene therapy applications would benefit from vectors capable of expressing multiple genes. In this study we explored the feasibility and efficiency of expressing two or three transgenes in HIV-1 based lentiviral vector. Bicistronic
Margison Geoffrey P, Shaaban Aimen F, Neuenfeldt James, Shaffer James, Milsom Michael D, Chinnasamy Dhanalakshmi, Fairbairn Leslie J, Chinnasamy Nachimuthu   +7 more
doaj   +1 more source

SERRATE Regulates Floral Meristem Activity by Antagonizing SHOOT MERISTEMLESS and Repressing Cytokinin Signaling

Advanced Science, EarlyView.
Floral meristem (FM) activity is crucial for the initiation of floral organs. In this study, SE represses IPT7 expression and cytokinin signaling via both the miR171c‐5p–KNAT2 and miR164c–CUC1/2–KNAT2 regulatory modules, thereby repressing FM activity. In contrast, STM induces both KNAT2 and IPT7 expression.
Wen Yang, Yiting Wang, Yuxin You, Zhiyue Wu, Dongbao Li, Xin Wang, Yongsheng Chang, Hang Zhao, Tao Zhu, Dijun Chen, Wei Chen, Bo Sun   +11 more
wiley   +1 more source

Аналіз успадкування трансгенів у генетично-модифікованих рослин пшениці, що містять гени метаболізму проліну

Фактори експериментальної еволюції організмів, 2016
Aim. Analysis of the marker and target genes inheritance in the progeny of transgenic wheat plants with proline metabolism genes. Methods. Agrobacteium-mediated transformation in vitro, genetic and statistical analysis. Results.
О. В. Дубровна, А. В. Бавол, С. С. Воронова, О. М. Гончарук   +3 more
doaj  

Expression and inheritance of multiple transgenes in rice plants

, 1998
The ability to control integration, inheritance, and expressipn of multiple transgenes is a prerequisite for manipulating biosynthetic pathways and complex agronomic characteristics in plants.
Zhang, S., Taylor, Nigel, Beachy, Roger, Philippe Marmey, Nigel J. Taylor, d'Cruz, Patricia, Marmey, Philippe, Alexandre de Kochko, Zhang, Shiping, Claude M. Fauquet, Patricia D'Cruz, Kochko, Alexandre de, Celia Espinoza, Beachy, R.N., Brizard, Jean-Paul, Hervé Huet, Huet, Hervé, Huet, H., Lili Chen, Espinoza, C., Espinoza, Celia, Chen, L., Roger N. Beachy, Fauquet, Claude, Chen, Lili, Shiping Zhang, Taylor, Nigel J., Jean-Paul Brizard, D'Cruz, P.   +28 more
core   +1 more source

CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction

Advanced Science, EarlyView.
CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma, Jiali Jia, Juncong Lan, Jing Wang, Dan Rao, Lanlan Rao, Weibin Zhang, Dongpeng Wu, Jie Zhang, Gang Wang, Baohua Liu, Ying Ao, Zimei Wang   +12 more
wiley   +1 more source

Intestinal peroxisome proliferator‐activated receptor α‐fatty acid‐binding protein 1 axis modulates nonalcoholic steatohepatitis

Hepatology, EarlyView., 2022
Abstract Background and Aims Peroxisome proliferator‐activated receptor α (PPARα) regulates fatty acid transport and catabolism in liver. However, the role of intestinal PPARα in lipid homeostasis is largely unknown. Here, intestinal PPARα was examined for its modulation of obesity and NASH. Approach and Results Intestinal PPARα was activated and fatty
Tingting Yan, Yuhong Luo, Nana Yan, Keisuke Hamada, Nan Zhao, Yangliu Xia, Ping Wang, Changdong Zhao, Dan Qi, Shoumei Yang, Lulu Sun, Jie Cai, Qiong Wang, Changtao Jiang, Oksana Gavrilova, Kristopher W. Krausz, Daxesh P. Patel, Xiaoting Yu, Xuan Wu, Haiping Hao, Weiwei Liu, Aijuan Qu, Frank J. Gonzalez   +22 more
wiley   +1 more source

Transgene inheritances and genetic similarities of near isogenic lines of genetically modified common beans Herança de transgenes e similaridade genética de linhagens quase isogênicas de feijoeiro-comum geneticamente modificado

Pesquisa Agropecuária Brasileira, 2009
The objective of the present work was to determine the inheritance and stability of transgenes of a transgenic bean line expressing the genes rep-trap-ren from Bean golden mosaic virus and the bar gene.
Patrícia Valle Pinheiro, Josias Corrêa de Faria, Elsa Oliveira Paranaguá e Lago Nogueira, Francisco José Lima Aragão   +3 more
doaj   +1 more source

Maize Transgenes Containing Zein Promoters are Regulated by opaque2

, 2011
Understanding epistatic interactions between transgenes and native genes is critical for predicting the response of transgenes to different genetic backgrounds and environments.
Scott, M. Paul, Floyd, Brice, Schroder, Megan   +2 more
core