Results 141 to 150 of about 70,182 (263)

Genetic analyses enabled by the fourth chromosome resource project reveal unexpected mutant phenotypes and suggest new disease models. [PDF]

G3 (Bethesda)
Weasner BM, Stinchfield MJ, Weasner BP, Takada S, O'Connor MB, Kumar JP, Newfeld SJ.   +6 more
europepmc   +1 more source

A New Vista of Opportunity in Diabetes Management: Natural Product‐Based β‐cell Preservation

Food Chemistry International, EarlyView.
Preserving functional β‐cells via natural products offers promising strategy for diabetes treatment. ABSTRACT A defining characteristic of diabetes is β‐cell failure, in which β‐cells cannot modulate insulin secretion to compensate for escalating insulin resistance, pushing forward disease development.
Yi‐San Lee, Tien‐Fen Kuo, Chun‐Yen Yang, Greta Yang, Wen‐Chin Yang   +4 more
wiley   +1 more source

Correction to 'Directed evolution of hyperactive integrases for site specific insertion of transgenes'. [PDF]

Nucleic Acids Res
europepmc   +1 more source

Pioneer Factor FOXA1 Boosts CHO Cell Productivity. [PDF]

Biotechnol J
Butterfield SP, Saunders FL, White RJ.
europepmc   +1 more source

Establishment of Salivary Gland Tumors Arising in Salivary Gland‐Specific EWSR1::ATF1 Transgenic Mice

Head &Neck, EarlyView.
ABSTRACT Background Salivary gland carcinomas are uncommon malignancies with various histological subtypes harboring fusion genes. The EWSR1::ATF1 fusion gene, resulting from a translocation between chromosomes 12 and 22, is frequently observed in hyalinizing clear cell carcinoma (HCCC). However, the role of this fusion gene in HCCC oncogenesis remains
Yuri Hirai, Yoshitaka Utsumi, Daisuke Sano, Tatsu Kuwahara, Yoshihiro Aizawa, Takashi Hatano, Hisashi Hasumi, Yutaro Soejima, Tatsukata Kawagoe, Ryosuke Jikuya, Nobuhisa Mizuki, Satoshi Fujii, Toshitaka Nagao, Nobuhiko Oridate   +13 more
wiley   +1 more source

Universal strategy to generate lentiviral vectors encoding lethal proteins. [PDF]

Mol Ther Adv
Versier B, Soundiramourty A, Manchon E, Ravassard P, Charron D, Christen Y, Mallet J, Al-Daccak R, Serguera C.   +8 more
europepmc   +1 more source

Specific pathogen free ten gene-edited donor pigs for xenotransplantation. [PDF]

Protein Cell
Xu K, Zhao H, Jia B, Wang J, Siddig NAMA, Jamal MA, Mao A, Liu K, Cheng W, Yang C, Wei T, Zhu F, Huo X, Jiao D, Guo J, Zhao H, Cheng W, Zhang Y, Zhang X, Jiang L, Zhang Z, Zhang W, Liang T, Zhao HY, Sun BC, Wei HJ.   +25 more
europepmc   +1 more source

Synergy between upregulated small GTPase immunity-associated proteins and lysosomal ATP6V1D in restricting intracellular <i>Toxoplasma</i> growth. [PDF]

Microbiol Spectr
Mia MM, Khan SM, Azam AR, Reilly J, Witola WH.   +4 more
europepmc   +1 more source

Strategies and mechanisms of precision genome engineering: From gene editing to genome writing

iMetaOmics, EarlyView.
In this review, we examined the progression of genome manipulation from stochastic nuclease‐mediated cutting toward precise editing and programmable genome writing. We discussed tools like multi‐kilobase RNA‐guided integrators and Artificial Intelligence (AI)‐designed effectors and showed how these advances enable researchers to treat genomes as ...
Kerui Huang, Jianhong Tian, Wenyan Zhao, Siqin Zhang, Lixuan Xiang, Meiqing Yang, Lu Liu, Yazhou Huang, Ningyun Zhang, Lei Sun, Peng Xie, Nanyu Kuang, Hong Zhou, Chengfeng Qiu, Jun Yan, Xiaocheng Jiang, Qiang Tu, Yun Wang, Haoliang Hu, Youming Zhang   +19 more
wiley   +1 more source

Double defense: enhancing tobacco with cyanobacterial and thaumatin genes. [PDF]

Front Bioeng Biotechnol
Kyrpa T, Prokhorova Y, Kharkhota M, Kuchuk M.   +3 more
europepmc   +1 more source