Results 161 to 170 of about 70,182 (263)

Transcription-dependent and -independent functions of Drosophila p53 isoforms in the induction of apoptosis and senescence-associated tumorigenesis. [PDF]

Cell Death Dis
Pérez-Aguilera M, Ruiz-Losada M, Gil Cortes P, Benchaib M, Rubio C, Baena-López LA, Baonza A, Estella C.   +7 more
europepmc   +1 more source

Recent Advances in Cryogel Applications for Musculoskeleatal Regeneration

Medicinal Research Reviews, EarlyView.
ABSTRACT Hydrogels have been widely used in tissue engineering due to their high‐water content and biocompatibility, yet their densely cross‐linked microstructure inherently limits cell infiltration, mass transport, and mechanical support. Cryogels, formed through partial freezing and crosslinking under subzero conditions, provide unique 3D macroporous
Dohee Kim, Shinwon Kang, Hyejin Jo, Inseon Kim, Seunghun S. Lee   +4 more
wiley   +1 more source

Conservation of CYP307 function between low-identity homologs. [PDF]

MicroPubl Biol
Perry CL, Robin C.
europepmc   +1 more source

Muscle‐Specific Kinase Signaling and Its Therapeutic Potential

Muscle &Nerve, EarlyView.
ABSTRACT The function of the neuromuscular junction (NMJ) is compromised in many neuromuscular diseases (NMDs) such as autoimmune or congenital myasthenia gravis (MG), amyotrophic lateral sclerosis (ALS), spinal muscular atrophy (SMA), and muscular dystrophies.
Stine Marie Jensen, Dana L. E. Vergoossen, Maartje G. Huijbers   +2 more
wiley   +1 more source

Polycomb repression works without Siesta, the <i>Drosophila</i> ortholog of mammalian PCGF3. [PDF]

Sci Adv
Kahn TG, Garrido A, Yushkova A, Kim M, Glotov A, Sreekumar S, Larsson J, Schwartz YB.   +7 more
europepmc   +1 more source

Strigolactone signaling: Licensing antiviral RNA interference in rice

New Plant Protection, EarlyView.
Rice grassy stunt virus (RGSV) suppresses strigolactone‐mediated antiviral RNAi through P3‐D14 interaction. Structure‐guided D14D102N editing disrupts P3 binding while maintaining SL signaling, sustaining antiviral defense and providing strong resistance without compromising plant growth or yield.
Kaibo Gu, Yanjun Li
wiley   +1 more source

Promoter toolset for CRE-mediated conditioned expression of genes during somatic gonad development in <i>Caenorhabditis elegans</i>. [PDF]

MicroPubl Biol
Borrego D, Fragoso-Luna A, Pérez-Martín J.   +2 more
europepmc   +1 more source

Restoration, Not Bypass: Otoferlin Gene Therapy and a New Era in Hearing Loss Treatment

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract The FDA approval of Otarmeni, an AAV‐based gene therapy for biallelic OTOF‐associated sensorineural hearing loss, represents a conceptual shift in otology: from bypassing defective auditory physiology to restoring it. Unlike cochlear implantation, which circumvents damaged sensory structures, OTOF gene replacement targets a synaptic deficit in
Jazlyn A. Selvasingh, Justin R. Shinn
wiley   +1 more source

Recent advances in site-specific transgene insertion into the maize genome using recombinases and genome editing endonucleases. [PDF]

Front Plant Sci
Basso MF, Pinto MS, Nonato JVA, Dante RA, Yassitepe JECT.   +4 more
europepmc   +1 more source

A temperature-sensitive CRISPR-Cas12a system for sterile insect technique. [PDF]

Nat Commun
Nguyen C, Omotayo AI, Sanz Juste S, Feng X, López Del Amo V.   +4 more
europepmc   +1 more source