Results 181 to 190 of about 70,182 (263)

Nonviral Gold Nanoparticle-Mediated Delivery of CRISPR-Cas9 Ribonucleoprotein and Long DNA Transgenes Into Primary Blood Cells. [PDF]

Adv Nanobiomed Res
Cunningham RA, Gottimukkala KSV, Lane DD, Poljakov K, Lipson P, Enstrom MR, Rizzi A, Chapuis AG, Adair JE.   +8 more
europepmc   +1 more source

Field performance of MON 94637 and laboratory evidence supporting a Bt pyramiding strategy against key lepidopteran pests in Brazil

Pest Management Science, EarlyView.
A genetically modified soybean expressing multiple Cry proteins protects against key lepidopteran pests, consistently reducing larval damage and offering an effective resistance management option for soybean production in Brazil. Abstract BACKGROUND Pyramided Bt genes in crops have been widely adopted to delay insect resistance evolution worldwide. The
Leonardo L Miraldo, Joacir do Nascimento, Thais LB dos Santos, Hallison V Vertuan, Luciana V Machado, Augusto C Crivellari, Márcia OMA José, Jessica Fernandez, Erick MG Cordeiro, Paula M Antunes, Samuel Martinelli, Graham P Head, Katherine Caldwell, Uma Kesanapalli, Ester Buiate, Patrick M Dourado, Ramiro FL Ovejero, Geraldo U Berger, Renato J Horikoshi   +18 more
wiley   +1 more source

Genomic Context and Insert Orientation in the Regulation of Transgene Expression in Adenoviral Vectors. [PDF]

Int J Mol Sci
Muravyeva A, Smirnikhina S.
europepmc   +1 more source

In planta analysis of the mode of action of cinmethylin and confirmation of fatty acyl‐ACP thioesterases (FATs) as primary site of action

Pest Management Science, EarlyView.
In planta analysis of the mode of action of cinmethylin and confirmation of fatty acyl‐ACP thioesterases (FATs) as primary site of action. Cinmethylin inhibits FATs, disrupting eukaryotic de novo lipid biosynthesis and causing defects in cell division, elongation and integrity. We confirm FATs as the primary site of action in planta.
Maximillian Pollmeier, Aisha Gerhardt, Janneke Hendriks, Katharina Kaprocki, Alexandra Zimmermann, Sarina Ruehm, Martina Marnet, Maria Stroe, Jorge Alfredo Rojas Biava, Clara Hofmann, Michael Betz, Sascha Schlaefer, Philipp Ternes, Jens Lerchl, Selene Garcia‐Hernandez, Philipp Johnen   +15 more
wiley   +1 more source

The <i>Arabidopsis</i> CYSTM α 5' UTR Increases Protein Production from Transgenes in Plants and Bacteria. [PDF]

Genes (Basel)
Khanduja JS, Wu X, Li J, Searle IR.
europepmc   +1 more source

Endocytosis‐independent cytosolic entry of messenger RNA via fluorous bilayer zippering attenuating Toll‐like receptor signaling and enables ischemic tissue salvage

Smart Molecules, EarlyView.
The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang, Haitao Xie, Guoqing Xiang, Yanhua Li, Changgui Tong, Hongyan Cui, Qixian Chen, Haidong Li, Yan Zhao   +8 more
wiley   +1 more source

A preclinical model for the identification of therapeutically active transgenes in local cancer immunotherapy. [PDF]

Oncoimmunology
Menze A, Ostroumov D, Wedemeyer HH, Volk V, Feuerhake F, Kühnel F, Wirth TC.   +6 more
europepmc   +1 more source

Harnessing the nonthermal effects of ultrasound for cancer treatment: From mechanisms to applications

Smart Molecules, EarlyView.
Nonthermal ultrasound transforms acoustic energy into diverse therapeutic bioeffects through cavitation, mechanical stimulation, and physicochemical activation. This review discusses how acoustic parameters, biological mechanisms, and responsive materials interact to influence nonthermal ultrasound‐enabled cancer therapies. Mechanism‐guided engineering
Liu Wang, Huan Tang, Yue Pan, Mingle Li, Weijie Zhao, Kai Liu   +5 more
wiley   +1 more source

Liver Xenotransplantation: From Early Primate Trials to the First-in-Human Porcine Bridging Therapies. [PDF]

J Clin Med
Nastase AG, Vasilescu AM, Trofin AM, Iftimie NF, Segura-Sampedro JJ, Cadar R, Buzincu I, Davidescu A, Nastase AL, Briceanu OG, Lupascu-Ursulescu C, Lupascu CD.   +11 more
europepmc   +1 more source

Nanomedicine applications in lymphoma: Advancing precision diagnostics, targeted therapeutics, and prospective developments

VIEW, EarlyView.
Lymphoma is a group of blood cancers that can appear in lymph nodes, blood, bone marrow, spleen, liver, or the central nervous system, which makes drug delivery and disease monitoring difficult. This review summarizes how nanomedicine technologies may improve targeted treatment and imaging, while carefully separating approved or guideline‐supported ...
Mohd Ahmar Rauf, Yara Mashal, Afeefa Rao, Nasar Ata, Arun K. Iyer, Farhan Shah   +5 more
wiley   +1 more source