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Application of transgenic mice to the molecular pathogenesis of cataract [PDF]
International Journal of OphthalmologyOne of the most prevalent disorders that cause blindness worldwide is cataract, and its essence is the visual disorder caused by the opacity of the lens. The significant degree of variation in cataracts and the fact that a variety of factors can impact a
Yue Zhang +5 more
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Molecules, 2022 COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global pandemic that might lead to very serious consequences. Notably, mental status change, brain confusion, and smell and taste disorders along with neurological ...
Simona Dedoni +6 more
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Tiam1 transgenic mice display increased tumor invasive and metastatic potential of colorectal cancer after 1,2-dimethylhydrazine treatment. [PDF]
PLoS ONE, 2013 BACKGROUND: T lymphoma invasion and metastasis 1 (Tiam1) is a potential modifier of tumor development and progression. Our previous study in vitro and in nude mice suggested a promotion role of Tiam1 on invasion and metastasis of colorectal cancer (CRC).
Li-Na Yu +7 more
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Transgenic Mouse Models for the Study of Neurodegenerative Diseases
Frontiers in Bioscience-Landmark, 2023 Neurodegenerative diseases (NDs) are some of the most important health challenges modern medicine and advanced societies face. Indeed, the number of patients affected by one of these illnesses will increase in the following years at the same rate that ...
Alba Marín-Moreno +4 more
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Comparative Analysis of Gastrointestinal Microbiota Between Normal and Caudal-Related Homeobox 2 () Transgenic Mice [PDF]
Intestinal Research, 2015 Background/AimsCaudal-related homeobox 2 (Cdx2) is expressed in the human intestinal metaplastic mucosa and induces intestinal metaplastic mucosa in the Cdx2 transgenic mouse stomach.
Hirotsugu Sakamoto +7 more
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Low CD4/CD8 T-cell ratio associated with inflammatory arthropathy in human T-cell leukemia virus type I Tax transgenic mice. [PDF]
PLoS ONE, 2011 BACKGROUND: Human T-cell leukemia virus type I (HTLV-1) can cause an aggressive malignancy known as adult T-cell leukemia/lymphoma (ATL) as well as inflammatory diseases such as HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP).
Takeo Ohsugi, Toshio Kumasaka
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Generation of Transgenic Mice [PDF]
Current Protocols in Cell Biology, 2009 AbstractThis unit describes detailed step‐by‐step protocols, reagents, and equipment required for successful generation of transgenic mice using pronuclear injection. The experimental methods and practical tips given here will help guide beginners in understanding what is required and what to avoid in these standard protocols for efficiently generating
Andrew Cho +2 more
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Thy1 transgenic mice expressing the red fluorescent calcium indicator jRGECO1a for neuronal population imaging in vivo. [PDF]
PLoS ONE, 2018 Calcium imaging is commonly used to measure the neural activity of large groups of neurons in mice. Genetically encoded calcium indicators (GECIs) can be delivered for this purpose using non-invasive genetic methods.
Hod Dana +8 more
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Journal of Diabetes Research, 2021 To rigorously explore the role of omega-3 polyunsaturated fatty acids (PUFA) in the treatment of diabetic peripheral neuropathy (DPN), we have created a transgenic mouse utilizing a Cre-lox promoter to control overexpression of human 15-lipoxygenase-1 ...
Lawrence Coppey +5 more
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Stem Cell Reports, 2014 The NAD-dependent deacetylase SIRT1 is involved in chromatin silencing and genome stability. Elevated SIRT1 levels in embryonic stem cells also suggest a role for SIRT1 in pluripotency.
Maria Luigia De Bonis +2 more
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