Real‐time imaging of Leishmania mexicana ‐infected early phagosomes: a study using primary macrophages generated from green fluorescent protein‐Rab5 transgenic mice [PDF]
, 2008 The small GTPase Rab5 is a key regulator of endosome/phagosome maturation and in intravesicular infections marks a phagosome stage at which decisions over pathogen replication or destruction are integrated.
Christoph Lippuner +9 more
openalex +3 more sources
Application of transgenic mice to the molecular pathogenesis of cataract [PDF]
International Journal of OphthalmologyOne of the most prevalent disorders that cause blindness worldwide is cataract, and its essence is the visual disorder caused by the opacity of the lens. The significant degree of variation in cataracts and the fact that a variety of factors can impact a
Yue Zhang +5 more
doaj +2 more sources
The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice
Nature, 2020 Linlin Bao, Wei Deng, Hong Gao
exaly +2 more sources
Pennisetum glaucum (L.) Oral Supplementation Mitigates Multi-Organic Dysfunction Associated with Carcinogenesis in HPV16-Transgenic Mice [PDF]
Current Issues in Molecular BiologyCancers induced by human papillomavirus are often associated with systemic inflammation and cachexia. This study aimed to determine the interference of Pennisetum glaucum oral supplementation over multi-organic dysfunction in HPV16-transgenic mice.
Paula A. Oliveira +10 more
doaj +2 more sources
Transgenic Overexpression of LARGE Induces alpha-Dystroglycan Hyperglycosylation in Skeletal and Cardiac Muscle [PDF]
, 2010 Background: LARGE is one of seven putative or demonstrated glycosyltransferase enzymes defective in a common group of muscular dystrophies with reduced glycosylation of alpha-dystroglycan.
Brockington, M +7 more
core +23 more sources
Molecules, 2022 COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global pandemic that might lead to very serious consequences. Notably, mental status change, brain confusion, and smell and taste disorders along with neurological ...
Simona Dedoni +6 more
doaj +1 more source
Tiam1 transgenic mice display increased tumor invasive and metastatic potential of colorectal cancer after 1,2-dimethylhydrazine treatment. [PDF]
PLoS ONE, 2013 BACKGROUND: T lymphoma invasion and metastasis 1 (Tiam1) is a potential modifier of tumor development and progression. Our previous study in vitro and in nude mice suggested a promotion role of Tiam1 on invasion and metastasis of colorectal cancer (CRC).
Li-Na Yu +7 more
doaj +1 more source
Transgenic Mouse Models for the Study of Neurodegenerative Diseases
Frontiers in Bioscience-Landmark, 2023 Neurodegenerative diseases (NDs) are some of the most important health challenges modern medicine and advanced societies face. Indeed, the number of patients affected by one of these illnesses will increase in the following years at the same rate that ...
Alba Marín-Moreno +4 more
doaj +1 more source
Comparative Analysis of Gastrointestinal Microbiota Between Normal and Caudal-Related Homeobox 2 () Transgenic Mice [PDF]
Intestinal Research, 2015 Background/AimsCaudal-related homeobox 2 (Cdx2) is expressed in the human intestinal metaplastic mucosa and induces intestinal metaplastic mucosa in the Cdx2 transgenic mouse stomach.
Hirotsugu Sakamoto +7 more
doaj +1 more source
AAV-mediated peripheral scFv's administration to reduce cerebral tau in adult P301S transgenic mice: Mono-vs. combination therapy. [PDF]
Mol Ther Methods Clin DevKatel S +11 more
europepmc +2 more sources