Results 111 to 120 of about 605,111 (136)
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1997
Publisher Summary Animals carrying new genes are referred to as transgenic. Transgenic animals are unique models that are custom-tailored to address a specific question associated with gene function. One of the more commonly used animals in transgenic techniques is the mouse species, as the methods involving the microinjection of transgenes into the ...
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Publisher Summary Animals carrying new genes are referred to as transgenic. Transgenic animals are unique models that are custom-tailored to address a specific question associated with gene function. One of the more commonly used animals in transgenic techniques is the mouse species, as the methods involving the microinjection of transgenes into the ...
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Transgenic Mice With Immunoglobulin Genes
Annual Review of Immunology, 1987Immunoglobulin (Ig) genes encode antibody molecules expressed exclu sively in the B-Iymphocyte lineage. The most immature identifiable cells of the B-cell lineage, pre-B cells, give rise to B cells that differentiate terminally into antibody secreting plasma cells.
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1989
The induction of mutations in transgenic mice represents a powerful experimental tool as it not only allows the derivation of precise animal models for human hereditary diseases but also permits a systematic genetic dissection of the mammalian genome.
Rudolf Jaenisch +3 more
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The induction of mutations in transgenic mice represents a powerful experimental tool as it not only allows the derivation of precise animal models for human hereditary diseases but also permits a systematic genetic dissection of the mammalian genome.
Rudolf Jaenisch +3 more
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Reporter genes in transgenic mice
Transgenic Research, 1994Although in vivo models utilizing endogenous reporter genes have been exploited for many years, the use of reporter transgenes to dissect biological issues in transgenic animals has been a relatively recent development. These transgenes are often, but not always, of prokaryotic origin and encode products not normally associated with eukaryotic cells ...
Cunqi Cui +4 more
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Development of btk Transgenic Mice
1995B cell development is characterized by the orderly expression of cell surface markers and responses to specific activation signals [1]. Tyrosine kinases are involved in signalling pathways that regulate these events [2]. Bruton’s tyrosine kinase (Btk) is a tyrosine kinase expressed in B and myeloid cells [3,4].
E. A. Faust +3 more
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Transgenic RNA Interference in Mice
Physiology, 2007The discovery that small interfering RNA duplexes (siRNA) can silence gene expression in mammalian cells has revolutionized biomedical research. The most successful application of the discovery has been to study gene function in cultured human or mouse cells. However, the knockdown effect of siRNA is only transient.
Xue Gao, Pumin Zhang
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Insertional mutagenesis in transgenic mice
Transgenic Research, 1994Increasing numbers of transgenic mouse lines have resulted in several dozens of mutants created by insertional mutagenesis. The advantages of different vector systems and the problems associated with the analysis of mutations and the cloning of the affected genes are discussed in this review.
Ulrich Rüther +2 more
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2012
Although the prion protein (PrP) was discovered in the early 1980s, there is still a considerable lack of knowledge of the normal function of the PrP protein and its precise role in the infectious process of transmissible spongiform encephalopathies (TSEs) or prion diseases.
Jean Manson +5 more
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Although the prion protein (PrP) was discovered in the early 1980s, there is still a considerable lack of knowledge of the normal function of the PrP protein and its precise role in the infectious process of transmissible spongiform encephalopathies (TSEs) or prion diseases.
Jean Manson +5 more
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Insertional Mutations in Transgenic Mice
1989Insertional mutagenesis represents a promising approach to the identification of new genes involved in mammalian development. In this paper, we have presented a brief review of the literature on the analysis of mutations caused by DNA and retroviral insertion into the mouse genome.
James J. Lee +5 more
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