Results 151 to 160 of about 1,644,173 (317)

Transgenic mice overexpressing Pitx2 in the atria develop tachycardia-bradycardia syndrome. [PDF]

PLoS One
Baba S, Shinjo S, Seya D, Bochimoto H, Akaike T, Nakano A, Minamisawa S.   +6 more
europepmc   +1 more source

Dietary cholesterol increases transcription of the human cholesteryl ester transfer protein gene in transgenic mice. Dependence on natural flanking sequences. [PDF]

, 1992
Xian‐Cheng Jiang, Luis B. Agellon, A Walsh, J L Breslow, Alan R. Tall   +4 more
openalex   +1 more source

FMO2 Promotes Angiogenesis via Regulation of N‐Acetylornithine

Advanced Science, EarlyView.
This study identifies flavin‐containing monooxygenase 2 (FMO2) as a novel proangiogenic regulator in endothelial cells. Targeted FMO2 ablation impairs vessel sprouting, whereas its compensation potently enhances angiogenesis. Metabolomics and single‐cell sequencing reveal that FMO2 drives vascular growth via the N‐acetylornithine/ATF3/NOTCH1 axis ...
Jingyi Wang, Yinghui Xu, Xianpeng Wu, Mo Li, Changchen Xiao, Zaiyang Fu, Yongjian Chen, Qingju Li, Yating Ruan, Jing Zhao, Zhiwei Zhong, Jinghai Chen, Wei Zhu, Jinliang Nan, Cheng Ni, Xinyang Hu   +15 more
wiley   +1 more source

Tissue-specific consequences of tag fusions on protein expression in transgenic mice. [PDF]

PLoS Genet
Taylor GCA, Macdonald L, Szulc NA, Gudauskaite E, Hernandez Moran B, Brisbane JM, Donald M, Taylor E, Zheng D, Gu B, Mill P, Yeyati PL, Pokrzywa W, Ribeiro de Almeida C, Wood AJ.   +14 more
europepmc   +1 more source

Organoid Modeling of Mouse Anterior Tongue Epithelium Reveals Regional and Cellular Identities

Advanced Science, EarlyView.
The tongue's anterior epithelium is maintained by region‐specific stem/progenitor cells, yet in vitro models are limited. Long‐term expanding organoids are developed from adult mouse anterior tongue that retain region‐specific identity, cellular diversity, and gene regulatory features. These organoids differentiate into keratinocytes, Merkel‐like cells,
Seok‐Young Kim, Laurens H. G. Verweij, Lin Lin, Johan H. van Es, Jay Slack, Chris Winkel, Tito Candelli, Philip Lijnzaad, Thanasis Margaritis, Gerben E. Breimer, Karin Sanders, Marc van de Wetering, Hans Clevers   +12 more
wiley   +1 more source

Inactivation of the porB gene reduces the virulence of Neisseria meningitidis in transgenic mice. [PDF]

BMC Microbiol
Klanger C, Deghmane AE, Eriksson L, Säll O, Hedberg ST, Mölling P, Taha MK.   +6 more
europepmc   +1 more source

Ectopic expression of Thy-1 in the kidneys of transgenic mice induces functional and proliferative abnormalities

, 1987
George Kollias, David J. Evans, Mary A. Ritter, J. N. Beech, Roger J. Morris, Frank Grosveld   +5 more
openalex   +1 more source

Developmental regulation of human gamma-globin genes in transgenic mice. [PDF]

, 1993
G. Stamatoyannopoulos, B Josephson, J W Zhang, Qiliang Li   +3 more
openalex   +1 more source

TREM2‐Mediated Cholesterol Efflux in Macrophages Inhibits Anti‐Tumor Immunity via Limitation of CD4+ T and NK Cells

Advanced Science, EarlyView.
Impaired anti‐tumor immunity is mediated by TREM2 + macrophages in non‐small cell lung cancer. TREM2 + macrophages prevent anti‐tumor immunity depending on the limitation of CD4 + T and NK cells. TREM2 promotes cholesterol efflux via ABCA1 to limit the production of CX3CL1 in macrophages.
Yunhan Wang, Weina Yu, Xinxin Wang, Qitai Zhao, Qingyang Lei, Aitian Li, Shasha Liu, Tian Wang, Li Yang, Yi Zhang   +9 more
wiley   +1 more source

Suppression of Glial Activation in Tau Transgenic Mice Through Inhibition of CRMP2 Phosphorylation: a Morphometric Analysis. [PDF]

Neuromolecular Med
Li W, Kubota T, Guevara VA, Goshima Y, Saido TC, Ohshima T.   +5 more
europepmc   +1 more source