Results 251 to 260 of about 1,842,059 (303)
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Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis, 2007
The development of peritoneal dialysis has been paralleled by a growing interest in establishing suitable experimental models to better understand the functional and structural processes operating in the peritoneal membrane. Thus far, most investigations have been performed in rat and rabbit models, with mechanistic insights essentially based on ...
Tomoya, Nishino +2 more
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The development of peritoneal dialysis has been paralleled by a growing interest in establishing suitable experimental models to better understand the functional and structural processes operating in the peritoneal membrane. Thus far, most investigations have been performed in rat and rabbit models, with mechanistic insights essentially based on ...
Tomoya, Nishino +2 more
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2013
The generation of transgenic mouse models has been a powerful technique for several decades and is still widely used. There have been many manuals and general reviews of this technology. This chapter is designed to be a "how-to" resource with detailed specifics.
Jennifer, Skelton +3 more
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The generation of transgenic mouse models has been a powerful technique for several decades and is still widely used. There have been many manuals and general reviews of this technology. This chapter is designed to be a "how-to" resource with detailed specifics.
Jennifer, Skelton +3 more
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Cryopreservation of Transgenic Mouse Lines
2003A transgenic animal represents an enormous investment in time and money. Animals can be destroyed through disease, fire, malfuncnons in the control of the environment, negligence, sabotage, or accidental disposal. Researchers can protect valuable transgenic lines from accrdental destruction by "banking" them in liquid nitrogen.
Jillian M, Shaw, Naomi, Nakagata
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Transgenic Mouse Colony Management
Current Protocols in Molecular Biology, 2005AbstractThis unit describes strategies and methods used to establish a colony of transgenic mice. Basic mating and genotyping strategies are introduced.
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Transgenic Mouse and Gene Therapy
Diabetes, 1996In the transgenic mouse, a specific gene can be transduced or deleted to study its function and relation to human diseases. Recently, various lines of transgenic mice that overexpress or lack a specific gene have been established and are available to study the pathophysiology of human diseases, including atherosclerosis, diabetes, and hyperlipidemia ...
K, Harada +3 more
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2009
With the development of the Cre-LoxP system, conditional gene targeting has rapidly become a powerful technology that facilitates the study of gene function. This advanced technique circumvents three major concerns sometimes levelled against conventional transgenic and gene-targeting approaches.
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With the development of the Cre-LoxP system, conditional gene targeting has rapidly become a powerful technology that facilitates the study of gene function. This advanced technique circumvents three major concerns sometimes levelled against conventional transgenic and gene-targeting approaches.
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Non-obese diabetic transgenic mouse
Springer Seminars in Immunopathology, 1992Several important conclusions can be drawn from these experiments and are as follows. First, not only the lack of I-E but also the presence of unique I-A are involved in the development of autoimmune insulitis in a NOD mouse. Second, the mechanism of prevention in I-Ak transgenic mice might be different from that in I-E transgenic mice, although the ...
K, Yamamura +4 more
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1986
This chapter discusses the preparation of the transgenic mouse. Transgenic mice are generated by the introduction of a cloned piece of DNA into a fertilized mouse egg, with subsequent growth of the embryo to birth and beyond. This method allows the function of specific genes and regulatory elements to be examined in the context of the whole animal with
Leonard G. Davis +2 more
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This chapter discusses the preparation of the transgenic mouse. Transgenic mice are generated by the introduction of a cloned piece of DNA into a fertilized mouse egg, with subsequent growth of the embryo to birth and beyond. This method allows the function of specific genes and regulatory elements to be examined in the context of the whole animal with
Leonard G. Davis +2 more
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Transgenic mouse models of Alzheimer's disease
Trends in Genetics, 2001Recent advances in the understanding of the genetic basis of Alzheimer's disease have enabled the production of transgenic mouse models of the disease. Utilizing both cDNA- and genomic-based approaches, these mouse models for Alzheimer's disease have already provided valuable insights into the pathogenesis of the disease and potential therapeutic ...
B J, Hock, B T, Lamb
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Inducible Transgenic Mouse Models
2010Inducible transgenic mouse models allow for the activation of genes in specific cells and tissues at specific times. Expression levels are dependent on the dose of the agent administered. Effective experimental models are characterized by low background levels of the regulated gene and induction to high levels with sub-physiological levels of inducing ...
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