Results 131 to 140 of about 3,961,294 (191)

Iron Homeostasis and Liver Diseases

Journal of Cellular and Molecular Medicine, Volume 30, Issue 20, October 2026.
ABSTRACT Iron is an essential micronutrient whose ability to cycle between ferric (Fe3+) and ferrous (Fe2+) states makes it crucial for physiological processes, including oxygen transport, DNA synthesis, and oxidative phosphorylation. However, because both deficiency and excess can cause severe pathology, precise regulation is critical. The liver plays
Peng Yang, Zhitian Shi, Qin Huang, Zhihong Tu, Yue Sun, Lin Wang, Yonglong Wei   +6 more
wiley   +1 more source

CELF2 promotes 4R Tau splicing via nuclear clustering and drives cognitive dysfunction in tauopathy models. [PDF]

Nat Commun
Li X, Syed I, Adhikari R, Jiang J, Zhang Y, Tang D, Ko SH, Zhang Z, Liu Z, Chen L.   +9 more
europepmc   +1 more source

Adding Tat‐Beclin1 to an endurance training program promotes additive improvements in physical function in aged male mice

Physiological Reports, Volume 14, Issue 19, October 2026.
Abstract Autophagy is a hallmark of aging, but it has not been exclusively targeted to attenuate aging‐related physical dysfunction. Here, we combined Tat‐Beclin1 and endurance training to determine its effect on physical function domains in aged male mice.
Thuan Thien Tchen, Shakibur Rahman, Thaysa Ghiarone, Lynn A. Spruce, Hossein Fazelinia, Elizabeth M. Brown, Charalampos Papachristou, Sue C. Bodine, Vitor A. Lira, Kleiton A. S. Silva   +9 more
wiley   +1 more source

Neuroinflammatory and Motor Alterations in LRRK2*G2019S Transgenic Mice Without Enhanced Vulnerability to Aging or Chronic MPTP-Induced Nigrostriatal Neurodegeneration. [PDF]

J Neurochem
García-Swinburn R, Morón-Márquez L, Conde-Naranjo C, García-Roldán E, Espadas I, Rodríguez-Gil A, Ramírez-Lorca R, Villadiego J, Toledo-Aral JJ.   +8 more
europepmc   +1 more source

Decoding MAPT Exon 10 Mis-Splicing in FTDP-17: From Pathogenic Mechanisms and Experimental Models to Molecular Therapies. [PDF]

Genes (Basel)
Covello G.
europepmc   +1 more source

Neurological tissue dissection techniques in mouse models for reproducible scientific results: Brain, spinal cord, cerebrospinal fluid, and sciatic nerve. [PDF]

PLoS One
Crew L, Seerley A, McElroy S, Panter AG.
europepmc   +1 more source

Non-coding RNAs and Mitochondrial Dysfunction in Alzheimer's Disease: A Systematic Review. [PDF]

Mol Neurobiol
Mocrei-Rebrean ȘM, Răzniceanu V, Pintilie SR, Berindan-Neagoe I.   +3 more
europepmc   +1 more source

Alignment between Duplex Sequencing and transgenic rodent mutation assay data in the assessment of in vivo NDMA-induced mutagenesis. [PDF]

Arch Toxicol
Ashford AL, Nachmanson D, Wills JW, Higgins JE, Smith TH, Vavra KC, Dahalan FA, Howe J, Elloway JM, Salk JJ, Doherty A, Lynch AM.   +11 more
europepmc   +1 more source

Mutagenic and carcinogenic potency determinations for NDMA support the cumulative dose assumption underpinning the less-than-lifetime Threshold of Toxicological Concern. [PDF]

Arch Toxicol
Wills JW, White A, Harte DSG, Buckley R, Harvey JS, Lynch AM.   +5 more
europepmc   +1 more source

Application of error-corrected sequencing technologies for in vivo regulatory mutagenicity assessment. [PDF]

Regul Toxicol Pharmacol
Yauk CL, Lynch AM, Dobrovolsky VN, Schuler M, Smith-Roe SL, Fitzgerald D, Higgins J, Honarvar N, Le Curieux F, Matsumura S, Minocherhomji S, Recio L, Salk JJ, Sugiyama KI, Suzuki T, Wills JW, Marchetti F.   +16 more
europepmc   +1 more source