Results 111 to 120 of about 3,961,294 (191)

Transgenic rodent gene mutation assays: performance characteristics and exploration of the effects of critical variables affecting the development of a standardized experimental protocol [PDF]

, 2018
openaire   +1 more source

In Transected Nerves, Distal Repair Schwann Cells at the Injury Site Direct and Accelerate Axonal Regrowth

Glia, Volume 74, Issue 10, October 2026.
After nerve transection in larval zebrafish, proximal and distal Schwann cells have distinct functions at the injury site. Distal repair Schwann cells promote axonal regrowth. Axonal regrowth is normal in mutants with only a few macrophages. ABSTRACT In vertebrate peripheral nerves, damaged axons can regrow after injury, but the outcomes of ...
Daniel E. Lysko, Annika R. Johnson, William S. Talbot   +2 more
wiley   +1 more source

Genetic and Pharmacological Targeting of Hsp72 Overexpression/Induction in an Alzheimer's Disease Mouse Model With Combined Amyloid and Tau Pathology

Journal of Neuroscience Research, Volume 104, Issue 10, October 2026.
We investigated targeting Hsp72 protein expression genetically and via a drug, in a model of combined amyloid and tau pathology. Neither approach reduced amyloid or tau or improved body composition or movement ability. Both treatments tended to slightly improve survival in male mice and anxiety‐like behavior in female mice.
J. P. S. Marshall, A. Harutyunyan, J. Ng, O. M. West, J. M. Collins, A. E. King, J. Morizzi, P. Wright, A. C. Calkin, B. G. Drew, N. C. Jones, P. A. Adlard, M. A. Febbraio, D. C. Henstridge   +13 more
wiley   +1 more source

Differential Mutagenic Response of Rat Liver and Lung to Nicotine-Derived Nitrosamine Ketone (NNK). [PDF]

Chem Res Toxicol
Jolly RA, Noteboom J, LeBlanc DPM, Marchetti F, Cavanagh KL, Minocherhomji S.   +5 more
europepmc   +1 more source

Posttranslational Modifications of p62/SQSTM1 in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
Schematic illustration of p62 as a posttranslational modifications (PTMs)‐programmed integrator in homeostasis, pathogenesis, and therapeutic targeting. (Left) Homeostasis: In physiological states, p62, through various PTMs such as phosphorylation, ubiquitination, and acetylation, coordinates essential cellular functions.
Weikai Wang, Xin Jiang, Runing Qiu, Chandra Sugiarto Wijaya, Miaoqin Chen, Jin Wang, Liyuan Zhu, Hongchuan Jin, Lifeng Feng   +8 more
wiley   +1 more source

Assessment of mutagenic potential of puberulic acid contaminated in red yeast rice (beni-koji) health food supplements. [PDF]

Mutagenesis
Sugiyama KI, Furuhama A, Horibata K, Tsuda M, Izawa K, Tsuji G, Demizu Y, Matsushita K, Toyoda T, Hirabayashi Y, Saito Y, Honma M.   +11 more
europepmc   +1 more source

Low Frequency of 185delAG Founder Mutation of BRCA1 Gene in Iranian Breast Cancer Patients [PDF]

AIM: The mutations in two breast cancer susceptibility genes, BRCA1 and BRCA2, are frequently associated with familial breast cancer. In this study, we aimed to investigate the probable founder mutations of BRCA1 and BRCA2 genes in Iranian breast ...
حسینی اصل, سید سعید, حبیبی, لاله, الوندی, احسان, مهدی پور, پروین, صوابی, آرزو, عطری, مرتضی   +5 more
core  

Brown Adipose Tissue: Molecular Mechanisms of Regulation, Physiological Functions, and Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
This review systematically covers three core dimensions of brown adipose tissue (BAT): multilayered regulatory mechanisms governing brown adipocyte differentiation and phenotypic identity, physiological functions and signaling pathways in mediating thermogenesis and systemic metabolic crosstalk between BAT and multiple organs, and emerging clinical in ...
Xiaoli Deng, Yuanyuan Shen, Ying Sun, Lu Lu, Chongkui Sun   +4 more
wiley   +1 more source

Evaluation of Type 1 Error Rates in Duplex Sequencing for Mutagenicity Testing Using Vehicle Control Data and Simulation Analyses. [PDF]

Environ Mol Mutagen
Williams A, Zhang S, Li D, Sun W, Schuler MJ, Marchetti F, Yauk CL.   +6 more
europepmc   +1 more source

Myelin Impairment and Regeneration in the Central Nervous System: Molecular Mechanisms, Diseases, and Prospective Therapeutic Targets

MedComm, Volume 7, Issue 10, October 2026.
Proper myelin formation is crucial for normal neural circuit function, while myelin deficiency can lead to neural circuit dysfunction and cognitive decline, notably in Alzheimer's disease and other central nervous system demyelinating disorders. This review summarizes central myelin's structure and function, demyelination biomarkers and pathological ...
Lihong Huang, Peng Cheng, Guangdong Liu, Yang Xiang, Zhen Hong, Weidong Le   +5 more
wiley   +1 more source