Results 101 to 110 of about 3,961,294 (191)
Animal Models and Experimental Medicine, Volume 9, Issue 10, Page 1964-1981, October 2026.Due to the complex pathophysiology of aortic valve disease (AVD) and the resulting lack of effective pharmacotherapy, existing animal models are valuable research tools, but each has its own strengths and limitations. This review systematically surveys the major AVD models, compares their induction methods, pathological features, advantages and ...
Liya Hou +4 more
wiley +1 more source
Biotechnology and Bioengineering, Volume 123, Issue 10, Page 2605-2612, October 2026.ABSTRACT Alpha‐1‐antitrypsin (A1AT) is a multifunctional, clinically important, high‐value therapeutic glycoprotein that can be used for the treatment of many diseases, such as A1AT deficiency, diabetes, graft‐versus‐host disease, cystic fibrosis, and various viral infections. Currently, the only U.S. food and drug administration‐approved treatment for
Frances Rocamora +12 more
wiley +1 more source
Biosafety Evaluation of Transgenic Potatoes: Genc Flow from Transgenic Potatoes
, 2011 A potential concern associated with the release of transgenic crops is the risk of gene flow to neighboring crops of the same species or to related species.
Anthony J. Conner
core
On the importance of including both sexes in animal studies – insights from home‐cage monitoring
Biological Reviews, Volume 101, Issue 5, Page 2408-2426, October 2026.ABSTRACT A review of behavioural studies using home‐cage monitoring (HCM) systems revealed that over 61% of studies used only male subjects, with only 24% including both sexes, despite evidence of substantial behavioural differences between male and female animals. This bias could influence the outcomes of biomedical research.
Maša Čater +12 more
wiley +1 more source
Investigating CD8 T Cell Exhaustion in Chronic LCMV Infection by Flow Cytometry
Current Protocols, Volume 6, Issue 10, October 2026.Abstract CD8 T cells and the process of T cell exhaustion are central topics in both basic immunology and translational research, including clinical applications. Here, we provide a comprehensive, step‐by‐step guide to investigate CD8 T cells in murine in vivo lymphocytic choriomeningitis virus (LCMV) infection models.
Dominique Stark +5 more
wiley +1 more source
Bioactive peptides in cancer and inflammation: Mechanisms, model systems and clinical translation
Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.Bioactive peptides (BAPs) derived from host, marine, insect, plant and synthetic sources share cationic, amphipathic structures adopting α‐helical, β‐sheet or cyclic conformations. These features underlie anti‐cancer effects, including membrane disruption, apoptosis and cell‐cycle arrest, anti‐metastatic activity, reduced invasion and migration, and ...
Najwa Doha +4 more
wiley +1 more source
Selection on PER2 Phosphorylation Regulation Underlies Atypical Mammalian Circadian Rhythms
Ecology and Evolution, Volume 16, Issue 10, October 2026.1. Positive selection on PER2 phosphorylation regulators in atypical circadian mammals. 2. Dolphin CSNK1E enhances PER2 phosphorylation at the stabilizing S662 site and extends PER2 half‐life. 3. Dolphin CSNK1E increases locomotor activity and reduces sleep in zebrafish.
Yujie Chong +8 more
wiley +1 more source
Environmental and Molecular Mutagenesis, Volume 67, Issue 8-9, October-November 2026.ABSTRACT Charged particles like iron‐56 ions impose health risks in long‐term manned space exploration. This study was designed to define the impact of Trp53 status upon the manifestation of mutations in the hypoxanthine‐guanine phosphoribosyltransferase (Hprt) gene in splenic T‐cells following exposure of Trp53 wild‐type, hemizygous, and nullizygous ...
Vernon E. Walker +3 more
wiley +1 more source
Epilepsia, Volume 67, Issue 10, Page 5075-5125, October 2026.Abstract This article summarizes data for 13 investigational treatments for which at least preliminary seizure outcome data in patients with epilepsy were reported at the Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices held in Madrid, Spain, on May 3–6, 2026.
Meir Bialer +7 more
wiley +1 more source
Epilepsia, Volume 67, Issue 10, Page 5042-5074, October 2026.Abstract Over the last 34 years, the Eilat Conference on New Antiepileptic Drugs and Devices has provided an interactive forum for stakeholders to discuss investigational and recently licensed treatments for seizures and epilepsy. The Eighteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XVIII) took place in Madrid, Spain, on May 3 ...
Meir Bialer +7 more
wiley +1 more source