Results 51 to 60 of about 332,647 (335)

Mouse hepatic lipase alleles with variable effects on lipoprotein composition and size[S]

Journal of Lipid Research, 2010
The structural features responsible for the activities of hepatic lipase (HL) can be clarified by in vivo comparisons of naturally occurring variants.
Serena M. Pratt, Sally Chiu, Glenda M. Espinal, Noreene M. Shibata, Howard Wong, Craig H. Warden   +5 more
doaj   +1 more source

Transgenic HepaRG cells expressing CYP2D6 as an improved model of primary human hepatocytes

Pharmacology Research & Perspectives, 2022
CYP2D6 and CYP3A4, which are members of the cytochrome P450 superfamily of metabolic enzymes, play major roles in the metabolism of commonly available drugs.
Shota Okuyama, Akari Mine, Teppei Nakamura, Yusuke Ohasi, Mayuko Seto, Masako Tada   +5 more
doaj   +1 more source

In Vivo Methods to Monitor Cardiomyocyte Proliferation

Journal of Cardiovascular Development and Disease, 2022
Adult mammalian cardiomyocytes demonstrate scarce cycling and even lower proliferation rates in response to injury. Signals that enhance cardiomyocyte proliferation after injury will be groundbreaking, address unmet clinical needs, and represent new ...
Alexander Young, Leigh A. Bradley, Matthew J. Wolf   +2 more
doaj   +1 more source

Transgenic Animal Technology

Journal of Andrology, 1997
There are numerous tools available to modify the genetic makeup of animals. They are being used to good advantage for studying basic biological phenomena. Within the decade, biomedical products derived from transgenic animals will be available, but the use of this technology for enhancing the quality and efficiency of livestock production will await ...
Wall, R. J., Hyman, P., Kerr, D., Pintado, B., Wells, K.   +4 more
openaire   +3 more sources

Production of trans-10, cis-12 conjugated linoleic acid in transgenic mice that express propionibacterium acnes isomerase [PDF]

, 2022
Yu Rao, Shili Li, Meijuan Li, yangyang Wang, Zongping Liu, Sheng Cui, Kemian Gou   +6 more
openalex   +1 more source

Visual Recovery Reflects Cortical MeCP2 Sensitivity in Rett Syndrome

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rett syndrome (RTT) is a devastating neurodevelopmental disorder with developmental regression affecting motor, sensory, and cognitive functions. Sensory disruptions contribute to the complex behavioral and cognitive difficulties and represent an important target for therapeutic interventions.
Alex Joseph Simon, Nathalie Picard, Valeria d'Andrea, Enchi Chang, Joseph Leffler, Eleonora Centofante, Matthew Taylor, Francesca Bardi, Francesca Cavicchiolo, Takao K. Hensch, Stefano Panzeri, Chinfei Chen, Michela Fagiolini   +12 more
wiley   +1 more source

A polêmica sobre os transgênicos: Monsanto vs. MST / The polemic about transgenic: Monsanto vs. MST

Bakhtiniana: Revista de Estudos do Discurso, 2011
RESUMO: Neste trabalho, adotando uma perspectiva discursiva, analisamos alguns aspectos do diálogo que se trava, no Brasil, entre o discurso pró e o anti-transgênicos, procurando evidenciar as relações dialógicas que cada um deles estabelece com outros ...
Anna Flora Brunelli
doaj  

Generation and characterization of a humanized ACE2 rat model for the study of SARS-CoV-2 and COVID-19

Frontiers in Microbiology
Our goal was to generate new rat strains for the study of human pathogenic viruses such as SARS-CoV-2 that use ACE2 for entry into host cells. An over-expression rat model was generated using random transgenesis to integrate copies of human ACE2 under ...
Rachel M. Olson, Rachel M. Olson, Henda Nabli, Henda Nabli, Bettina A. Gentry, Daniel J. Davis, Daniel J. Davis, Craig L. Franklin, Craig L. Franklin, Mary L. Shaw, Mary L. Shaw, Elizabeth C. Bryda, Elizabeth C. Bryda, Elizabeth C. Bryda   +13 more
doaj   +1 more source

Diagnostic Utility of Testing for Novel Murine Autoantibodies for Sjögren's Disease in the Rheumatology Outpatient Setting

Arthritis Care &Research, Accepted Article.
Objective The goal was to assess the diagnostic performance of three novel autoantibodies (NA) for Sjögren's disease (SjD) by comparing NA prevalence in patients with SjD, other autoimmune rheumatic diseases (ARDs), nonspecific chronic sialadenitis (CS), and controls.
Chadwick R. Johr, Michael D. George, Vatinee Y. Bunya, Nora Sandorfi, Mina Massaro‐Giordano, Frederick B. Vivino   +5 more
wiley   +1 more source

Transgenics, agroindustry and food sovereignty

Letras Verdes: Revista Latinoamericana de Estudios Socioambientales, 2014
Food sovereignty has been implemented constitutionally in Ecuador; however, many of the actions and policies are designed to benefit the dominant model of food production, based in agroindustry, intensive monocultures, agrochemicals and transgenics. This
Xavier Alejandro León Vega
doaj   +1 more source