Results 91 to 100 of about 4,824 (245)

Neurodegenerative diseases and transglutaminase [PDF]

Proceedings of the National Academy of Sciences, 1996
The idea that transglutaminase (TG), a posttranslational protein crosslinking enzyme (for reviews, see refs. 1–6), might be involved in the pathology of neurodegenerative diseases, notably of Alzheimer disease (AD), was first suggested by the experiments of Selkoe et al. (7, 8).
openaire   +2 more sources

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Evolutionary relationships of microbial transglutaminases

, 2017
Transglutaminases (TGases) are a class of enzyme widely spread in nature, and observed in plants, microorganisms, vertebrates and invertebrates. This enzyme catalyzes post-translational protein modification, by acyl transfer reactions, deamidation and ...
Deborah Giordano, Angelo Facchiano
core   +1 more source

Piezo1 in Smooth Muscle Cells Is Involved in Hypertension-Dependent Arterial Remodeling

Cell Reports, 2015
The mechanically activated non-selective cation channel Piezo1 is a determinant of vascular architecture during early development. Piezo1-deficient embryos die at midgestation with disorganized blood vessels.
Kevin Retailleau, Fabrice Duprat, Malika Arhatte, Sanjeev Sumant Ranade, Rémi Peyronnet, Joana Raquel Martins, Martine Jodar, Céline Moro, Stefan Offermanns, Yuanyi Feng, Sophie Demolombe, Amanda Patel, Eric Honoré   +12 more
doaj   +1 more source

Sustainable and Programmable Hydrogels for Bone Regeneration: A Perspective on Green Synthesis and Precision Fabrication

SusMat, EarlyView.
The clinical translation of natural hydrogels is often hindered by a fundamental conflict. Green synthesis prioritizes biosafety through mild and non‐toxic conditions, whereas precision manufacturing demands mechanical robustness and structural fidelity.
Jiaxin Wu, Xu Wang, Hanfei Li, Xibo Pei, Hao Feng, Jian Wang   +5 more
wiley   +1 more source

Genome Expansion of ZPB1(a) and ZPC1(a) in Basal Species or Liver Expression of ZPB1a and ZPC1aa in Advanced Species, Two Different Strategies to Ensure Sufficient ZP Synthesis in Teleosts

Integrative Zoology, EarlyView.
We found that teleosts employed two different strategies to ensure sufficient ZP (zona pellucida) synthesis: expansion of ZPB1(a) and ZPC1(a) in basal species or liver expression of ZPB1a and ZPC1aa in advanced species. The N‐terminus of expanded ZPB1(a) or ZPC1(a) and liver‐expressed ZPB1a contains repeated units or low‐complexity regions to form ...
Tian Gao, Suying Ma, Shiyi Zhang, Fan Bai, Lingyao Gan, Wenjing Tao, Feilong Wang, Deshou Wang, Lina Sun   +8 more
wiley   +1 more source

Interpreting the mechanism of action of polyamines: twenty years of plant transglutaminases

, 2009
The post-translational modification of proteins by polyamines forming inter- or intra-molecular cross-links has been the main transglutaminase (TGase) reaction studied in plants.
DELLA MEA, MASSIMILIANO, DEL DUCA, STEFANO, IORIO, ROSA ANNA, SERAFINI FRACASSINI, DONATELLA   +3 more
core   +1 more source

Therapeutic potential of elafin in airway inflammatory disease

European Journal of Inflammation
Elafin, which is derived from trappin-2 or pre-elafin by proteolysis, is an endogenous serine protease inhibitor with a low molecular weight. Its inhibitory activity is dependent on anchoring to the extracellular matrix by forming covalent bonds with its
Mingxin He, Yalou Yang, Yanyan Li, Xiangdong Zhou, Li Xu, Ziwei Zhang, Hua Zhang, Qi Li   +7 more
doaj   +1 more source

Emollient Formulations and Skin Barrier Practices in the Context of Eczema and Food Allergy Prevention

Allergy, EarlyView.
ABSTRACT The skin is far from a passive shield; it functions as a dynamic “living barrier” whose structural and immunological integrity is paramount in preventing atopic dermatitis (AD) and the subsequent progression of the atopic march toward food allergy (FA).
Klaudia Ryczaj, Donald Y. M. Leung, Carina Venter, Barbara Sozańska, Helen A. Brough   +4 more
wiley   +1 more source

Transglutaminases in inflammation and fibrosis of the gastrointestinal tract and the liver

, 2009
Transglutaminases are a family of eight currently known calcium-dependent enzymes that catalyze the cross-linking or deamidation of proteins. They are involved in important biological processes such as wound healing, tissue repair, fibrogenesis ...
Bardella M. T., BERGAMINI, Carlo, Elli L., Schuppan D., Bergamini C. M.   +4 more
core   +1 more source