Results 111 to 120 of about 4,824 (245)

Fibrillar‐Type Dermatitis Herpetiformis: An Underrecognized Variant That Is Rarely Associated With Celiac Disease and Lacking Epidermal Transglutaminase Deposition: A Report of Two Cases

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Dermatitis herpetiformis (DH) is a rare, intensely pruritic cutaneous manifestation of celiac disease (CD), typically presenting with excoriated papulovesicular lesions on extensor surfaces. DH is associated with IgA autoantibodies against epidermal transglutaminase (eTG), which form granular immune deposits in the papillary dermis and induce ...
Jeffrey Damman, Elodie Mendels, Sven van der Woude, Sharon Veenbergen, Gilles F. H. Diercks, Martijn B. van Doorn   +5 more
wiley   +1 more source

The harnessing potential of carboxymethyl beta glucan: A driver of skin repair

International Journal of Cosmetic Science, EarlyView.
Carboxymethyl Beta‐Glucan (CM‐BG) drives skin repair through multifaceted actions, notably in wounded 3D models. It activates Dectin‐1 and mitigates inflammation (reducing pro‐inflammatory mediators, boosting anti‐inflammatory IL‐10) in cellular models, while enhancing epidermal differentiation and collagen I synthesis by fibroblasts across cellular ...
Caroline Pichon, Xavier Marat, Alice Brule, Annie Black, Audrey Gueniche   +4 more
wiley   +1 more source

Context‐Dependent Regulation of Epithelial Cell Behaviour by Palatal Connective Tissue Graft‐Derived Fibroblasts via EGF and HB‐EGF Signalling

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aim To investigate how human palatal fibroblasts (HPFs) from anterior (A) or posterior (P) subepithelial connective tissue grafts (CTGs) regulate oral epithelial cell behaviour, focusing on epidermal growth factor (EGF) and heparin‐binding EGF‐like growth factor (HB‐EGF).
Xiaoqing Song, Cristina Nica, Alexandra Stähli, Anton Sculean, Maria B. Asparuhova   +4 more
wiley   +1 more source

Histone serotonylation promotes pancreatic cancer development via lipid metabolism remodeling

Nature Communications
Neurotransmitter serotonin (5-hydroxytryptamine [5-HT]) has emerged to play parallel roles in both neurobiology and oncology. Apart from receptor-mediated signaling transduction pattern, serotonin can be covalently integrated into histone (the post ...
Sang Lin, Sheng Tan, Yonglin Peng, Aziguli Tulamaiti, Wenfei Du, Keshuo Ding, Changyu Chen, Jun Wu, Hua Li, Wei Xu, Jielin Sun, Xue-Li Zhang, Zhi-gang Zhang, Xiaodong Zhao   +13 more
doaj   +1 more source

Management of chronic urticaria: Current status and future prospect

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Chronic urticaria is driven by mast cell activation through autoimmune, inflammatory, and neuroimmune pathways. A structured approach combining diagnosis, patient‐reported outcomes, stepwise therapy, treatment optimization, monitoring and emerging targeted agents may improve disease control and enable more personalized management.
Andaç Salman, Mona Al‐Ahmad, Maryam Al‐Nesf, Chia‐Yu Chu, Luis Felipe Ensina, Ana M. Gimenez‐Arnau, Margarida Gonçalo, Clive Grattan, Michihiro Hide, Pavel Kolkhir, Martin Metz, Iman Nasr, Romi Saini, Simon Francis Thomsen, Torsten Zuberbier, Emek Kocaturk   +15 more
wiley   +1 more source

Transglutaminase-2 differently regulates cartilage destruction and osteophyte formation in a surgical model of osteoarthritis

, 2009
Osteoarthritis is a progressive joint disease characterized by cartilage degradation and bone remodeling. Transglutaminases catalyze a calcium-dependent transamidation reaction that produces covalent cross-linking of available substrate glutamine ...
Di Lascio, A, Melino, G, SPAGNOLI, LUIGI GIUSTO, DI LASCIO A, SPAGNOLI LG, MELINO, GENNARO, Oliva F, Oliva, F, Candi, E, CANDI E, Taurisano, G, ORLANDI, AUGUSTO, CANDI, ELEONORA, Tarantino, U, TARANTINO U, TARANTINO, UMBERTO, Orlandi A, Orlandi, A, TAURISANO G, Spagnoli, L, MELINO G   +20 more
core   +1 more source

Beyond neurotransmission: the roles of serotonylation in physiological and pathological processes

Cellular & Molecular Biology Letters
Serotonin, also known as 5-HT, is a classical neurotransmitter produced both in the nervous system and in non-nervous system. Its involvement in various fundamental physiological processes and pathogenic conditions is significant, as it binds to a ...
Jia-Ming Wang, Feng-Hao Zhang, Yi-Ru Chen, Dan-Ni Chen, Xiao Wang, Hai-Yun Xie, Jiang-Feng Li, Jin-Dan Luo, Li-Ping Xie   +8 more
doaj   +1 more source

Immune‐related adverse events with mogamulizumab in cutaneous T‐cell lymphoma: A multicentre study

Journal of the European Academy of Dermatology and Venereology, EarlyView.
In a nationwide multicentre study of 403 patients with cutaneous T‐cell lymphoma treated with mogamulizumab, non‐MAR immune‐related adverse events were reported in 8.4% of patients across responding centres. These events were diverse, sometimes severe or persistent, and could occur late during mogamulizumab treatment.
David Neubauer, Pascale Palassin, Caroline Ram‐Wolff, Adèle De Masson, Jeremie Delaleu, Diane Kottler, Florent Amatore, Henri Adamski, Claudia Bejar, Raphaël Janela‐Lapert, Emmanuella Guenova, Pauline Bernard, Coralie Lheure, Laurent Machet, Laura Troin, Gaëlle Quereux, Anne Pham‐Ledard, Sarah Faiz, Florent Grange, Yannick Le Corre, Arjen Nikkels, Stéphane Barete, Lorena Manea, Emmanuelle Amazan, Alexandre Tj Maria, Lionel Moulis, Olivier Dereure, Quentin Samaran, For the Groupe Français d'Étude des Lymphomes Cutanés (GFELC)   +28 more
wiley   +1 more source

Analysis of transglutaminase protein substrates by functional proteomics

, 2003
Transglutaminases are calcium-dependent enzymes that catalyze a post-translational modification of proteins through the formation of ε-(γ-glutamyl)lysine bonds.
Stefania Orrù, Paolo Rovero, P. ROVERO, Margherita Ruoppolo, C. ESPOSITO, M. Ruoppolo, A. D'Amato, Carla Esposito, Simona Francese, RUOPPOLO, MARGHERITA, G. MARINO, S. ORRU’, Alfonsina D'Amato, Gennaro Marino, A. D’AMATO, S. FRANCESE, S. Orrù, ORRU', STEFANIA, ROVERO P. AND ESPOSITO C., FRANCESE S, RUOPPOLO M, D'AMATO A   +21 more
core   +1 more source

Detection of oral transglutaminases and their relevance in celiac disease [PDF]

, 2015
Thesis (MSD) --Boston University, Henry M. Goldman School of Dental Medicine, 2015 (Department of Molecular and Cell Biology).Includes bibliography: leaves 46-50.Celiac disease (CD) is an autoimmune disorder characterized by enteropathy caused by ...
Shen, Shiqian
core   +1 more source