Results 81 to 90 of about 11,438 (267)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Transient characterization and amplitude-phase compensation control for GFM-DFIG considering grid voltage phase jump

International Journal of Electrical Power & Energy Systems
The grid-forming doubly-fed induction generator possesses the ability to construct voltage and frequency. However, under grid fault conditions, it encounters issues such as transient instability, fault overcurrent, and insufficient reactive power support.
Pingjuan Ge, Ruitong Mao, Hailiang Xu, Yishuo Yang   +3 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Research on high-frequency transient characteristics of wind farm integrated transmission systems based on excitation-response port cascaded network

International Journal of Electrical Power & Energy Systems
Considering the agglomeration effect of renewable energy, traditional “equivalence-aggregation” models of wind farms fail to accurately depict detailed fault characteristics.
Jing Ma, Zhuoer Gao, Jun Cao
doaj   +1 more source

Coordinating fault ride through strategy for connection of offshore wind farms using VSC-HVDC under single polar fault

The Journal of Engineering, 2019
Bipolar VSC-HVDC scheme is one of the most feasible transmission technologies to integrate offshore wind energy source. While one pole stops by suffering even a transient fault, the other pole will block soon due to the overcurrent, then the wind ...
Siyang Ge, Kaipei Liu, Liang Qin, Xiaohong Ran, Gang Li, Qingxin Pu, Dong Liu   +6 more
doaj   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

A tool for detecting transient faults in execution of parallel scientific applications on multicore clusters

Journal of Computer Science and Technology, 2014
Transient faults are becoming a critical concern among current trends of design of general-purpose multiprocessors. Because of their capability to corrupt programs outputs, their impact gains importance when considering long duration, parallel scientific
Diego Miguel Montezanti, Enzo Rucci, Dolores Rexachs del Rosario, Emilio Luque Fadón, Marcelo Naiouf, Armando Eduardo De Giusti   +5 more
doaj  

Fault Section Location Based on Transient Zero-Sequence Current Waveform Dissimilarity for Single-Phase Grounding Faults in Distribution Networks

Energies
A fault-section location method based on waveform-difference analysis of transient zero-sequence currents is proposed for distribution networks with small-current grounding systems.
Yuxing Lei, Bo Li, Yingjie Yin, Ling Wei, Jiao Sun, Zhensheng Wu   +5 more
doaj   +1 more source