Results 191 to 200 of about 773,655 (299)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Improved Protocol for Efficient Agrobacterium-Mediated Transient Gene Expression in Medicago sativa L. [PDF]

Plants (Basel)
Basak S, Parajulee D, Dhir S, Sangra A, Dhir SK.   +4 more
europepmc   +1 more source

A Highly Efficient Agrobacterium-Mediated Method for Transient Gene Expression and Functional Studies in Multiple Plant Species. [PDF]

Plant Commun, 2020
Zhang Y, Chen M, Siemiatkowska B, Toleco MR, Jing Y, Strotmann V, Zhang J, Stahl Y, Fernie AR.   +8 more
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Optimized Production of Virus-like Particles in a High-CHO-Cell-Density Transient Gene Expression System for Foot-and-Mouth Disease Vaccine Development. [PDF]

Vaccines (Basel)
Mignaqui AC, Ferella A, Sánchez C, Stuible M, Scian R, Filippi J, Cardillo SB, Durocher Y, Wigdorovitz A.   +8 more
europepmc   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Isolation of Haustorium Protoplasts Optimized by Orthogonal Design for Transient Gene Expression in Phelipanche aegyptiaca. [PDF]

Plants (Basel)
Zeng X, Cao X, Zhao Q, Hou S, Hu X, Yang Z, Hao T, Zhao S, Yao Z.   +8 more
europepmc   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Agrobacterium-Mediated Transient Gene Expression Optimized for the Bioenergy Crop Camelina sativa. [PDF]

Bio Protoc
Kumar P, Banday ZZ, Riley JL, Greenberg JT.   +3 more
europepmc   +1 more source

Radish sprouts as an efficient and rapidly available host for an agroinfiltration-based transient gene expression system. [PDF]

Plant Biotechnol (Tokyo), 2020
Kitajima S, Miura K, Yasuda J.
europepmc   +1 more source