Transient Receptor Potential Ankyrin 1 (TRPA1) Modulation by 4-Hydroxynonenal (4-HNE) in Pancreatic Adenocarcinoma Cell Lines: Putative Roles for Therapies. [PDF]
Pharmaceuticals (Basel)Piciu F +10 more
europepmc +1 more source
Inhibition of Dorsal Root Ganglia Transient Receptor Potential Ankyrin 1 Upregulation Contributes to the Protective Effect of Morphine Against Gastric Mucosal Damage Induced by Water-Immersion Restraint Stress. [PDF]
Turk J GastroenterolJiang Q +7 more
europepmc +1 more source
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Activation of Transient Receptor Potential Ankyrin 1 by Hydrogen Peroxide
European Journal of Neuroscience, 2008AbstractHydrogen peroxide (H2O2), which is contained in industrial products, is also generated within cells. H2O2 causes pain but it has not been elucidated how it activates sensory neurons in the pain pathway. Here we show that transient receptor potential ankyrin 1 (TRPA1), expressed by sensory neurons in the pain pathway, is a receptor for H2O2 ...
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Modulation of Transient Receptor Vanilloid 1 Activity by Transient Receptor Potential Ankyrin 1
Molecular Pharmacology, 2014Transient receptor potential vanilloid 1 (TRPV1) is a nonselective ligand-gated cation channel responding to noxious heat, protons, and chemicals such as capsaicin. TRPV1 is expressed in sensory neurons and plays a critical role in pain associated with tissue injury, inflammation, and nerve lesions.
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Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists
Pharmaceutical Patent Analyst, 2015The transient receptor potential ankyrin 1 (TRPA1) channel is an irritant sensor highly expressed on nociceptive neurons. The clinical use of TRPA1 antagonists is based on the concept that TRPA1 is active during disease states like neuropathic pain.
PRETI, Delia +2 more
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Activation of transient receptor potential ankyrin 1 by eugenol
Neuroscience, 2014Eugenol is a bioactive plant extract used as an analgesic agent in dentistry. The structural similarity of eugenol to cinnamaldehyde, an active ligand for transient receptor potential ankyrin 1 (TRPA1), suggests that eugenol might produce its effect via TRPA1, in addition to TRPV1 as we reported previously.
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Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: A Patent Review (2015–2019)
Expert Opinion on Therapeutic Patents, 2020TRPA1 is a non-selective cation channel predominantly expressed in sensory neurons, and functions as an irritant sensor for a plethora of noxious external stimuli and endogenous ligands. Due to its involvement in pain, itch, and respiratory syndromes, TRPA1 has been pursued as a promising drug target.In this review, the small molecule patent literature
Huifen Chen, Jack A Terrett
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Expression of Transient Receptor Potential Ankyrin 1 in Human Dental Pulp
Journal of Endodontics, 2012Transient receptor potential ankyrin 1 (TRPA1) is activated by noxious cold (
Yun Sook, Kim +6 more
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Transient Receptor Potential Ankyrin 1 Is Expressed by Inhibitory Motoneurons of the Mouse Intestine
Gastroenterology, 2011Transient receptor potential ankyrin (TRPA) 1, an excitatory ion channel expressed by sensory neurons, mediates somatic and visceral pain in response to direct activation or noxious mechanical stimulation. Although the intestine is routinely exposed to irritant alimentary compounds and inflammatory mediators that activate TRPA1, there is no direct ...
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