Results 151 to 160 of about 11,052 (171)
Transient Receptor Potential Ankyrin 1 Mediates Toluene Diisocyanate–Evoked Respiratory Irritation [PDF]
American Journal of Respiratory Cell and Molecular Biology, 2009 Abstract Toluene diisocyanate (TDI), a reactive, hazardous irritant, causes respiratory symptoms such as cough, rhinitis, dyspnea, and chest tightness in exposed workers. Although previous animal studies have shown that TDI causes respiratory reflexes that are abolished by desensitization of capsaicin-sensitive sensory nerves, the ...
Thomas E Taylor-Clark +2 more
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Neuroscience Letters, 2008
Transient receptor potential ankyrin-1 (TRPA1) is an important receptor that contributes to inflammatory pain. However, previous studies were mainly concerned with its function in somatic hyperalgesia while few referred to visceral, especially colonic inflammatory hyperalgesia.
Xiu-Li Zuo, Yanbo Yu
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Transient receptor potential ankyrin-1 (TRPA1) is an important receptor that contributes to inflammatory pain. However, previous studies were mainly concerned with its function in somatic hyperalgesia while few referred to visceral, especially colonic inflammatory hyperalgesia.
Xiu-Li Zuo, Yanbo Yu
exaly +3 more sources
Transient receptor potential ankyrin 1 (TRPA1)-mediated cough
European Respiratory Journal, 2011TRPA1 detects many endogenous inflammatory and environmental pollutant molecules. Previous studies implicated TRPA1 as a drug target for antitussive therapy. We evaluated relative efficacy of the TRPA1 activation in inducing cough in guinea pigs.
Mariana Brozmanova +4 more
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Transient receptor potential ankyrin 1 (TRPA1) modulators: Recent update and future perspective
European Journal of Medicinal Chemistry, 2023The transient receptor potential ankyrin 1 (TRPA1) channel is a non-selective cation channel that senses irritant chemicals. Its activation is closely associated with pain, inflammation, and pruritus. TRPA1 antagonists are promising treatments for these diseases, and there has been a recent upsurge in their application to new areas such as cancer ...
Zelin, Hu +7 more
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Neuroscience, 2011
Paclitaxel chemotherapy is limited by a long-lasting painful neuropathy that lacks an effective therapy. In this study, we tested the hypothesis that paclitaxel may release mast cell tryptase, which activates protease-activated receptor 2 (PAR2) and, subsequently, protein kinases A and C, resulting in mechanical and thermal (both heat and cold ...
Y, Chen, C, Yang, Z J, Wang
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Paclitaxel chemotherapy is limited by a long-lasting painful neuropathy that lacks an effective therapy. In this study, we tested the hypothesis that paclitaxel may release mast cell tryptase, which activates protease-activated receptor 2 (PAR2) and, subsequently, protein kinases A and C, resulting in mechanical and thermal (both heat and cold ...
Y, Chen, C, Yang, Z J, Wang
openaire +2 more sources
Role of Transient Receptor Potential Ankyrin 1 in Gastric Accommodation in Conscious Guinea Pigs
The Journal of Pharmacology and Experimental Therapeutics, 2012We report the establishment of a new model for measuring gastric tone and liquid meal-induced accommodation in conscious guinea pigs and the role played by transient receptor potential ankyrin 1 (TRPA1). An indwelling polyethylene bag was placed in proximal stomachs of 5-week-old male Hartley guinea pigs. Gastric tone was measured by distending the bag
Junichi, Koseki +8 more
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Transient Receptor Potential Ankyrin 1 in Diabetes
2019Diabetic neuropathy (DN) is a common complication of diabetes, which is often associ-ated with a loss of peripheral sensitivity, but pain is also a common symptom and early manifestation of DN. Detailed mechanisms responsible for the neuropathy and the painful symptoms in diabetes are unknown.
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Human Transient Receptor Potential Ankyrin 1 Channel: Structure, Function, and Physiology
The transient receptor potential ion channel TRPA1 is a Ca2+-permeable nonselective cation channel widely expressed in sensory neurons, but also in many nonneuronal tissues typically possessing barrier functions, such as the skin, joint synoviocytes, cornea, and the respiratory and intestinal tracts.Viktorie, Vlachova +2 more
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