Results 181 to 190 of about 133,784 (309)

Correction to Supporting Information for Ma et al., Transient receptor potential channel TRPC5 is essential for P-glycoprotein induction in drug-resistant cancer cells. [PDF]

Proc Natl Acad Sci U S A, 2023
europepmc   +1 more source

Modulation of the Transient Receptor Potential Vanilloid Channel TRPV4 by 4α-Phorbol Esters: A Structure−Activity Study

, 2009
Thomas Kjær Klausen, Alberto Pagani, Alberto Minassi, Abdellah Ech‐Chahad, Jean Prenen, Grzegorz Owsianik, Else K. Hoffmann, Stine F. Pedersen, Giovanni Appendino, Bernd Nilius   +9 more
openalex   +1 more source

Multifunctional Gold Nanocluster‐Based PROTAC System for Targeted Degradation of Phosphorylated Tau and Modulation of Neuroinflammation in Alzheimer's Disease

Advanced Functional Materials, EarlyView.
We present a novel proteolysis‐targeting chimera (PROTAC) system conjugated to lipoic acid gold nanoclusters (PLANC), designed to degrade pTau, regulate inflammatory signaling, and effectively traverse the blood‐brain barrier (BBB). PLANC degraded pTau at various phosphorylation sites, with mechanistic studies confirming proteasome‐mediated degradation
Sarah Nevins, Callan D. McLoughlin, Wan‐Kyu Ko, Hye Kyu Choi, Brandon Conklin, Joshua B. Stein, Yannan Hou, Hongwon Kim, Rohan Khulbe, Ki‐Bum Lee   +9 more
wiley   +1 more source

Porcine transient receptor potential channel 1 promotes adipogenesis and lipid deposition. [PDF]

J Lipid Res
Fu Y, Hao X, Nie J, Shang P, Dong X, Zhang B, Yan D, Zhang H.   +7 more
europepmc   +1 more source

Gastrointestinal motility modulation by stress is associated with reduced smooth muscle contraction through specific transient receptor potential channel. [PDF]

J Vet Med Sci, 2021
Azuma YT, Suzuki S, Nishiyama K, Yamaguchi T.   +3 more
europepmc   +1 more source

Inhibitory regulation of constitutive transient receptor potential‐like cation channels in rabbit ear artery myocytes

, 2004
Anthony P. Albert, W. A. Large
openalex   +1 more source

Low‐Profile, High‐Gain GRIN RF Lenses via Multi‐Material Vat Photopolymerization

Advanced Functional Materials, EarlyView.
We investigate the opportunity of leveraging multi‐material vat photopolymerization printing to manufacture intricate lenses exhibiting permittivity gradients that can increase signal gain in transmitted radiofrequency signals in the X‐ and Ku‐bands. Lenses produced with more distinct low‐loss materials (up to 5) can deliver an 18 dB signal gain with a
Lawrence Romangsuriat, Alexander Peraire‐Bueno, A. John Hart, Randall M. Erb   +3 more
wiley   +1 more source

Loss of transient receptor potential channel 5 causes obesity and postpartum depression. [PDF]

Cell
Li Y, Cacciottolo TM, Yin N, He Y, Liu H, Liu H, Yang Y, Henning E, Keogh JM, Lawler K, Mendes de Oliveira E, Gardner EJ, Kentistou KA, Laouris P, Bounds R, Ong KK, Perry JRB, Barroso I, Tu L, Bean JC, Yu M, Conde KM, Wang M, Ginnard O, Fang X, Tong L, Han J, Darwich T, Williams KW, Yang Y, Wang C, Joss S, Firth HV, Xu Y, Farooqi IS.   +34 more
europepmc   +1 more source

Lysosome‐Acidifying Nanoparticles Rescue A30P α‐Synuclein Induced Neuronal Death in Cellular and Drosophila Models of Parkinson's Disease

Advanced Healthcare Materials, EarlyView.
Lysosome‐targeted acidic nanoparticles based on a biodegradable poly(ethylene tetrafluorosuccinate‐co‐succinate) copolymer are engineered to restore impaired lysosomal acidification through pH‐responsive intracellular degradation. Localized acid release enhances autophagic proteolysis, reduces α‐synuclein accumulation, and preserves dopaminergic neuron
Chih Hung Lo, Mengda Ren, Gavin Wen Zhao Loi, Eka Norfaishanty Saipuljumri, Jonathan Indajang, Kah Leong Lim, Jialiu Zeng   +6 more
wiley   +1 more source

The anthelmintic meclonazepam activates a schistosome transient receptor potential channel. [PDF]

J Biol Chem
Park SK, Sprague DJ, Rohr CM, Chulkov EG, Petrow I, Kumar S, Marchant JS.   +6 more
europepmc   +1 more source