Management of suspected opioid‐induced hyperalgesia in a dog
Veterinary Record Case Reports, Volume 14, Issue 2, May 2026.Abstract Opioid‐induced hyperalgesia is a recognised phenomenon in people, but few cases are described in veterinary patients. This case reports a dog with suspected opioid‐induced hyperalgesia after a stick injury to the mouth and neck, and subsequent surgical exploration of the ventral neck and abscess debridement.
Robin Stallard +2 more
wiley +1 more source
Diosgenin Exerts Analgesic Effects by Antagonizing the Selective Inhibition of Transient Receptor Potential Vanilloid 1 in a Mouse Model of Neuropathic Pain. [PDF]
Int J Mol Sci, 2022 Rahman MM, Jo HJ, Park CK, Kim YH.
europepmc +1 more source
Polymodal TRPV1 and TRPV4 sensors colocalize but do not functionally interact in a subpopulation of mouse retinal ganglion cells [PDF]
, 2018 Baumann, Jackson M +5 more
core +2 more sources
Opioids in breast cancer: Between analgesia and modulation of tumour progression
British Journal of Pharmacology, Volume 183, Issue 9, Page 1727-1746, May 2026.Preclinical investigations consistently demonstrate that activation of μ‐opioid receptors and δ‐opioid receptors promote proliferation, migration, angiogenesis, epithelial‐mesenchymal transition, acquisition of cancer stem cell phenotypes, and chemoresistance.
Marianna Ciwun +2 more
wiley +1 more source
Transient Receptor Potential Vanilloid 1 Signaling Is Independent on Protein Kinase A Phosphorylation of Ankyrin-Rich Membrane Spanning Protein. [PDF]
Med Sci (Basel), 2022 Pellegrino A +5 more
europepmc +1 more source
Headache: The Journal of Head and Face Pain, Volume 66, Issue 5, Page 1181-1192, May 2026.Abstract Objective To highlight key factors required to optimize multi‐mechanistic approaches with oral combination treatments for the acute management of a migraine attack. Background Given the complex multi‐factorial nature of migraine, combining treatments with different mechanisms of action should improve outcomes compared to monotherapies, but ...
Stephen Silberstein, Alan M. Rapoport
wiley +1 more source
Transient receptor potential vanilloid 1 (TRPV1; VR1) [PDF]
Science-Business eXchange, 2011 openaire +3 more sources
Animal Models of Hunner‐Type Interstitial Cystitis
International Journal of Urology, Volume 33, Issue 5, May 2026.ABSTRACT Background Animal models are crucial for mechanistic studies and therapeutic development of human diseases. At present, the etiology of interstitial cystitis/bladder pain syndrome (IC/BPS), a chronic disease of the urinary bladder, remains undefined.
Yoshiyuki Akiyama, Yi Luo
wiley +1 more source
Zhenxin Anshen formula ameliorates atopic der-matitis-like skin dysfunction in mice and regulation of transient receptor potential vanilloid 1 and transient receptor potential ankyrin 1 in Neural pathways. [PDF]
J Tradit Chin Med, 2023 Yiding Z +6 more
europepmc +1 more source
Microvascular Effects of Endocannabinoid Signaling in Sepsis: A Mechanistic and Systematic Review
Microcirculation, Volume 33, Issue 4, May 2026.ABSTRACT Microvascular dysfunction is a central determinant of organ failure in sepsis, reflecting early endothelial activation, increased permeability, and impaired capillary perfusion. Experimental evidence suggests that the endocannabinoid system (ECS) modulates these immunovascular processes, yet mechanistic insights remain dispersed across ...
Emanuel F. Matias +2 more
wiley +1 more source