Transient receptor potential vanilloid type 1: cardioprotective effects in diabetic models [PDF]
Channels, 2023 Cardiovascular disease, especially heart failure (HF) is the leading cause of death in patients with diabetes. Individuals with diabetes are prone to a special type of cardiomyopathy called diabetic cardiomyopathy (DCM), which cannot be explained by ...
Jiaqi Bao +4 more
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Does Transient Receptor Potential Vanilloid Type 1 Alleviate or Aggravate Pathological Myocardial Hypertrophy? [PDF]
Frontiers in Pharmacology, 2021 Transient receptor potential vanilloid type 1 (TRPV1) is a non-selective cation channel, which is involved in the endogenous stress adaptation mechanism for protection of the heart as well as the occurrence and development of some heart diseases ...
Qiqi Yan +11 more
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Transient receptor potential vanilloid type-1 regulates periodontal disease damage via the PI3K/AKT signaling pathway [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): This study aimed to investigate the function of transient receptor potential vanilloid 1 (TRPV1) in regulating periodontal lesions. In addition, we explored the underlying mechanism of the phosphatidylinositol 3-kinase/protein kinase B ...
xiaolu xu +3 more
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A journey from molecule to physiology and in silico tools for drug discovery targeting the transient receptor potential vanilloid type 1 (TRPV1) channel [PDF]
Frontiers in Pharmacology, 2023 The heat and capsaicin receptor TRPV1 channel is widely expressed in nerve terminals of dorsal root ganglia (DRGs) and trigeminal ganglia innervating the body and face, respectively, as well as in other tissues and organs including central nervous system.
Cesar A. Amaya-Rodriguez +7 more
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2-Kidney-1-clip hypertension is not attenuated in mice lacking the transient receptor potential vanilloid type 1 (TRPV1) channel [PDF]
Frontiers in PhysiologyIntroductionChemical ablation of renal sensory nerves using agonists for transient receptor potential vanilloid-1 (TRPV1) lowers arterial blood pressure (ABP) in multiple experimental models of hypertension.
Sean D. Stocker +3 more
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The stress protein heat shock cognate 70 (Hsc70) inhibits the Transient Receptor Potential Vanilloid type 1 (TRPV1) channel [PDF]
Molecular Pain, 2016 Background Specialized cellular defense mechanisms prevent damage from chemical, biological, and physical hazards. The heat shock proteins have been recognized as key chaperones that maintain cell survival against a variety of exogenous and endogenous ...
Mircea Iftinca PhD +6 more
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Respiratory virus infection up-regulates TRPV1, TRPA1 and ASICS3 receptors on airway cells. [PDF]
PLoS ONE, 2017 Receptors implicated in cough hypersensitivity are transient receptor potential vanilloid 1 (TRPV1), transient receptor potential cation channel, Subfamily A, Member 1 (TRPA1) and acid sensing ion channel receptor 3 (ASIC3).
Shadia Omar +10 more
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Iron overload causes osteoporosis in thalassemia major patients through interaction with transient receptor potential vanilloid type 1 (TRPV1) channels [PDF]
Haematologica, 2014 The pathogenesis of bone resorption in β-thalassemia major is multifactorial and our understanding of the underlying molecular and cellular mechanisms remains incomplete.
Francesca Rossi +10 more
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Constitutive activity of transient receptor potential vanilloid type 1 triggers spontaneous firing in nerve growth factor-treated dorsal root ganglion neurons of rats [PDF]
IBRO Reports, 2018 Dorsal root ganglion (DRG) neurons cultured in the presence of nerve growth factor (NGF, 100 ng/ml) often show a spontaneous action potential. Underlying mechanisms of this spontaneous firing were examined using the patch clamp technique. The spontaneous
Naoki Kitamura +4 more
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Role of Known Transient Receptor Potential Vanilloid Channels in Modulating Cardiac Mechanobiology
Frontiers in Physiology, 2021 The transient receptor potential (TRP) channels have been described in almost every mammalian cell type. Several members of the Vanilloid (TRPV) subtype have been found to play important roles in modulating cardiac structure and function through Ca2 ...
Michael Miller +6 more
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