Transient Receptor Potential Vanilloid Type 1 Receptors in Hypertensive Renal Damage [PDF]
Hypertension, 2008 In the development and progression of hypertensive organ damage, hemodynamic factors such as high pressure, turbulent flow, and shear stress are thought to cause endothelial dysfunction and vascular remodeling. Nephrosclerosis may eventually result from a complex cascade of inflammatory and fibrotic processes. Research on novel therapeutic targets has,
Tilmann, Ditting +2 more
openaire +2 more sources
Cannabinoid and Cannabinoid-Related Receptors in the Myenteric Plexus of the Porcine Ileum
Animals, 2021 An important piece of evidence has shown that molecules acting on cannabinoid receptors influence gastrointestinal motility and induce beneficial effects on gastrointestinal inflammation and visceral pain.
Andrea Toschi +6 more
doaj +1 more source
Frontiers in Physiology, 2022 The transient receptor potential vanilloid subtype 1 (TRPV1), belonging to the TRPV channel family, is a non-selective, calcium-dependent, cation channel implicated in several pathophysiological processes. Collagen, an extracellular matrix component, can
Guangxin Peng +10 more
doaj +1 more source
Contemporary views on inflammatory pain mechanisms: TRPing over innate and microglial pathways. [PDF]
, 2016 Tissue injury, whether by trauma, surgical intervention, metabolic dysfunction, ischemia, or infection, evokes a complex cellular response (inflammation) that is associated with painful hyperalgesic states.
Guan, Zhonghui +2 more
core +2 more sources
Carcinogenesis and Metastasis: Focus on TRPV1-Positive Neurons and Immune Cells
Biomolecules, 2023 Both sensory neurons and immune cells, albeit at markedly different levels, express the vanilloid (capsaicin) receptor, Transient Receptor Potential, Vanilloid-1 (TRPV1).
Nuray Erin, Arpad Szallasi
doaj +1 more source
Elevated expression of transient receptor potential vanilloid type 1 in dorsal root ganglia of rats with endometriosis. [PDF]
Mol Med Rep, 2017 Pain is the most pronounced complaint of women with endometriosis, however the underlying mechanism is still poorly understood. In the present study, the authors evaluate the effect of transient receptor potential vanilloid type 1 (TRPV1) of dorsal root ganglia (DRG) on endometriosis-associated pain.
Lian YL, Cheng MJ, Zhang XX, Wang L.
europepmc +4 more sources
N-Arachidonoyl Dopamine Modulates Acute Systemic Inflammation via Nonhematopoietic TRPV1. [PDF]
, 2017 N-Arachidonoyl dopamine (NADA) is an endogenous lipid that potently activates the transient receptor potential vanilloid 1 (TRPV1), which mediates pain and thermosensation. NADA is also an agonist of cannabinoid receptors 1 and 2.
Hellman, Judith +7 more
core +2 more sources
Genes and primary headaches: discovering new potential therapeutic targets [PDF]
, 2013 Genetic studies have clearly shown that primary headaches (migraine, tension-type headache and cluster headache) are multifactorial disorders characterized by a complex interaction between different genes and environmental factors.
De Martino, Paola +8 more
core +3 more sources
TRPV1 channels are critical brain inflammation detectors and neuropathic pain biomarkers in mice [PDF]
, 2017 The capsaicin receptor TRPV1 has been widely characterized in the sensory system as a key component of pain and inflammation. A large amount of evidence shows that TRPV1 is also functional in the brain although its role is still debated.
Chiurchiù, Valerio +16 more
core +3 more sources
Presynaptic inhibition of transient receptor potential vanilloid type 1 (TRPV1) receptors by noradrenaline in nociceptive neurons [PDF]
The Journal of Physiology, 2017 Key pointsThe transient receptor potential vanilloid type 1 (TRPV1) receptor is a polymodal molecular integrator in the pain pathway expressed in Aδ‐ and C‐fibre nociceptors and is responsible for the thermal hyperalgesia associated with inflammatory pain.Noradrenaline strongly inhibited the activity of TRPV1 channels in dorsal root ganglia neurons ...
Saikat Chakraborty +4 more
openaire +2 more sources