Results 41 to 50 of about 23,801 (234)

Possible Involvement of the Transient Receptor Potential Vanilloid Type 1 Channel in Postoperative Adhesive Obstruction and Its Prevention by a Kampo (Traditional Japanese) Medicine, Daikenchuto

Journal of Pharmacological Sciences, 2011
This study focused on the localization of transient receptor potential vanilloid type 1 (TRPV1) in the intestines in postoperative adhesion model rats and investigated the underlying mechanism for the anti-adhesion action of daikenchuto (DKT), especially
Yohei Tokita, Masahiro Yamamoto, Kazuko Satoh, Mitsue Nishiyama, Seiichi Iizuka, Sachiko Imamura, Yoshio Kase   +6 more
doaj   +1 more source

Genetic Background Can Result in a Marked or Minimal Effect of Gene Knockout (GPR55 and CB2 Receptor) in Experimental Autoimmune Encephalomyelitis Models of Multiple Sclerosis [PDF]

, 2013
PMCID ...
A Compston, A Shetty, A Zimmer, AC Howlett, AE Bygrave, C Bolton, C Delarasse, C Delarasse, C Teuscher, Carolyn Tanner, CS Wu, CS Wu, D Baker, D Baker, D Baker, D Baker, D Baker, D Baker, D Baker, D McHugh, David Baker, David L. Selwood, DL Smith-Bouvier, E de Lago, E Kozela, E Montero, E Zurita, F Docagne, F Wu, G Disanto, G Musumeci, G Paltser, G Pryce, G Pryce, G Wotherspoon, Gareth Pryce, Gavin Giovannoni, Gregory J. Michael, H Kataoka, HM Vesterinen, I Mendel, J Corey-Bloom, J Karlsson, J Palazuelos, JA Encinas, JB Davis, JH Slingsby, JK O'Neill, JL Croxford, JL Croxford, JM Coquet, JP Zajicek, K Li, K Maresz, KM Spach, L Cristino, LM Olsson, LS Whyte, M Sundvall, M Webb, MF Festing, NA Balenga, NE Buckley, O Ofek, PC Staton, PD Fillmore, PM Hoi, RA Ross, RA Ross, RC Axtell, RG Pertwee, RG Pertwee, RJ Butterfield, Roberto Furlan, RS Graves, Ruth A. Ross, S Al-Izki, S Al-Izki, S Amor, S Amor, S Amor, S Katona, S Levine, S Levine, S Rossi, S Saadoun, Samuel J. Jackson, SC Landis, SJ Allen, Sofia Sisay, V Devonshire, Y Okuda, ZY Lou   +92 more
core   +3 more sources

Transient Receptor Potential Vanilloid Type-1 Channel in Cardiometabolic Protection

Journal of the Korean Society of Hypertension, 2011
❙ABSTRACT❙ Transient receptor potential vanilloid type-1 channel (TRPV1) is a non-selective cation channel with a preference for calcium ions that is able to sense a vast range of endogenous physical and chemical stimuli and plays an important role in transducing the sensations of noxious heat and pain signaling.
Peijian Wang, Daoyan Liu, Zhiming Zhu
openaire   +1 more source

Selective disruption of high sensitivity heat activation but not capsaicin activation of TRPV1 channels by pore turret mutations. [PDF]

, 2012
The capsaicin receptor transient receptor potential vanilloid (TRPV)1 is a highly heat-sensitive ion channel. Although chemical activation and heat activation of TRPV1 elicit similar pungent, painful sensation, the molecular mechanism underlying ...
Cao, Xu, Cui, Yuanyuan, Wang, KeWei, Yang, Fan, Yarov-Yarovoy, Vladimir, Zheng, Jie   +5 more
core   +1 more source

Targeting CB2 and TRPV1: Computational Approaches for the Identification of Dual Modulators

Frontiers in Molecular Biosciences, 2022
Both metabotropic (CBRs) and ionotropic cannabinoid receptors (ICRs) have implications in a range of neurological disorders. The metabotropic canonical CBRs CB1 and CB2 are highly implicated in these pathological events.
Paula Morales, Chanté Muller, Nadine Jagerovic, Patricia H. Reggio   +3 more
doaj   +1 more source

Molecular Sensors and Modulators of Thermoreception [PDF]

, 2015
Peer ...
Zhang, Xuming
core   +1 more source

Structural insights on TRPV5 gating by endogenous modulators. [PDF]

, 2018
TRPV5 is a transient receptor potential channel involved in calcium reabsorption. Here we investigate the interaction of two endogenous modulators with TRPV5.
Carnevale, Vincenzo, Carnevale|, Fluck, Edwin C., Hughes, Taylor E. T., Huynh, Kevin W., Kasimova, Marina A., Kasimova|, Moiseenkova-Bell, Vera Y., Molugu, Sudheer K., Pumroy, Ruth A., Rohacs, Tibor, Samanta, Amrita, Yazici, Aysenur Torun, Zhou, Z. Hong   +13 more
core   +3 more sources

Differential regulation of bladder pain and voiding function by sensory afferent populations revealed by selective optogenetic activation [PDF]

, 2010
Bladder-innervating primary sensory neurons mediate reflex-driven bladder function under normal conditions, and contribute to debilitating bladder pain and/or overactivity in pathological states. The goal of this study was to examine the respective roles
DeBerry, Jennifer J, Samineni, Vijay K, Copits, Bryan A, Sullivan, Christopher J, Vogt, Sherri K, Albers, Kathryn M, Davis, Brian M, Gereau, Robert W, IV   +7 more
core   +4 more sources

Transient Receptor Potential Vanilloid 1 — a Polymodal Nociceptive Receptor — Plays a Crucial Role in Formaldehyde-Induced Skin Inflammation in Mice

Journal of Pharmacological Sciences, 2012
Formaldehyde (FA) is irritating to the skin and is the main cause of sick building syndrome. However, the cutaneous reaction induced by long-term FA exposure has not been fully investigated.
Haruki Usuda, Takumi Endo, Ayumi Shimouchi, Asaka Saito, Makoto Tominaga, Hirotaka Yamashita, Hiroichi Nagai, Naoki Inagaki, Hiroyuki Tanaka   +8 more
doaj   +1 more source

TRPV4: Molecular Conductor of a Diverse Orchestra [PDF]

, 2016
Transient receptor potential vanilloid type 4 (TRPV4) is a calcium-permeable nonselective cation channel, originally described in 2000 by research teams led by Schultz ( Nat Cell Biol 2: 695 –702, 2000) and Liedtke ( Cell 103: 525–535, 2000).
Cibelli, Mario, McGeown, J. Graham, Nagy, Istvan, Nilius, Bernd, Urban, Laszlo, White, John P M   +5 more
core   +1 more source