Results 11 to 20 of about 23,801 (234)

A Molecular Basis for the Inhibition of Transient Receptor Potential Vanilloid Type 1 by Gomisin A. [PDF]

Evid Based Complement Alternat Med, 2017
Transient receptor potential (TRP) channel has critical actions as conditional sensors in primary afferent neurons. We studied the regulatory action of gomisin A on TRPV1 channel current in this report. Schisandra chinensis contains bioactive compounds such as the gomisin derivatives and their related compounds.
Lee SB, Noh S, Yeom HD, Jo H, Eom S, Kim YS, Nam S, Bae H, Lee JH.   +8 more
europepmc   +4 more sources

Transient receptor potential vanilloid type 1 is expressed in the horizontal pathway of the vervet monkey retina. [PDF]

Sci Rep, 2020
AbstractThe ubiquitous distribution of the classic endocannabinoid system (cannabinoid receptors CB1 and CB2) has been demonstrated within the monkey nervous system, including the retina. Transient receptor potential vanilloid type 1 (TRPV1) is a cannabinoid-like non-selective cation channel receptor that is present in the retina and binds to ...
Bouskila J, Micaelo-Fernandes C, Palmour RM, Bouchard JF, Ptito M.   +4 more
europepmc   +5 more sources

Transient receptor potential vanilloid type 1 channel may modulate opioid reward. [PDF]

Neuropsychopharmacology, 2014
Transient receptor potential vanilloid type 1 (TRPV1), a nonselective cation channel, is a well-known pain-related receptor. TRPV1 involvement in morphine-induced antinociception, tolerance, and withdrawal symptoms has been previously reported. Emerging evidence indicates that TRPV1 may be related to both the cellular and behavioral effects of ...
Nguyen TL, Kwon SH, Hong SI, Ma SX, Jung YH, Hwang JY, Kim HC, Lee SY, Jang CG.   +8 more
europepmc   +4 more sources

Regulation of high-fat diet-induced microglial metabolism by transient receptor potential vanilloid type 1

Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023
Objective·Transcriptomic and lipidomic analysis techniques were used to investigate the role of transient receptor potential vanilloid type 1 (TRPV1) channel activation in the regulation of high-fat diet-induced microglial metabolism.Methods·Eight-week ...
SHA Xudong, WANG Chenfei, LU Jia, YU Zhihua   +3 more
doaj   +1 more source

Expression, Distribution and Function of the Transient Receptor Potential Vanilloid Type 1 (TRPV1) in Endometrial Cancer. [PDF]

Int J Mol Sci
The transient receptor potential vanilloid 1 receptor (TRPV1) is a calcium-sensitive membrane receptor activated by capsaicin and the endocannabinoid, anandamide (AEA). Once activated in vitro, endometrial cancer (EC) cell growth appears to be inhibited through increased apoptosis, but the mechanism remains unclear.
Ayakannu T, Taylor AH, Konje JC.
europepmc   +3 more sources

Implication of transient receptor potential vanilloid type 1 in 14,15-epoxyeicosatrienoic acid-induced angiogenesis. [PDF]

Int J Biol Sci, 2014
14,15-epoxyeicosatrienoic acid (14,15-EET) is implicated in regulating physiological functions of endothelial cells (ECs), yet the potential molecular mechanisms underlying the beneficial effects in ECs are not fully understood. In this study, we investigated whether transient receptor potential vanilloid receptor type 1 (TRPV1) is involved in 14,15 ...
Su KH, Lee KI, Shyue SK, Chen HY, Wei J, Lee TS.   +5 more
europepmc   +4 more sources

Transient Receptor Potential Type Vanilloid 1 Suppresses Skin Carcinogenesis [PDF]

Cancer Research, 2009
Abstract Blockade of the transient receptor potential channel vanilloid subfamily 1 (TRPV1) is suggested as a therapeutic approach to pain relief. However, TRPV1 is a widely expressed protein whose function might be critical in various nonneuronal physiologic conditions.
Ann M, Bode, Yong-Yeon, Cho, Duo, Zheng, Feng, Zhu, Marna E, Ericson, Wei-Ya, Ma, Ke, Yao, Zigang, Dong   +7 more
openaire   +2 more sources

TRPV4-A Missing Link Between Mechanosensation and Immunity [PDF]

, 2020
Transient receptor potential vanilloid-type 4 (TRPV4) cation channel is widely expressed in all tissues as well as in immune cells and its function as mechanosensitive Ca2+ channel seems to be conserved throughout all mammalian species. Of late, emerging
Kuebler, Wolfgang M., Michalick, Laura
core   +1 more source

Pain Treatment in the Companion Canine Model to Validate Rodent Results and Incentivize the Transition to Human Clinical Trials

Frontiers in Pharmacology, 2021
One of the biggest challenges for analgesic drug development is how to decide if a potential analgesic candidate will work in humans. What preclinical data are the most convincing, incentivizing and most predictive of success?
Michael J. Iadarola, Dorothy Cimino Brown, Alexis Nahama, Matthew R. Sapio, Andrew J. Mannes   +4 more
doaj   +1 more source

Furanocoumarins are a novel class of modulators for the transient receptor potential vanilloid type 1 (TRPV1) channel. [PDF]

J Biol Chem, 2014
Furanocoumarin imperatorin is the major active component of Angelica dahurica root extracts, widely used in traditional medicine to treat headache, toothache, and orbital eye pain. In this study, we investigated the mechanisms that may underlie the pain-relieving effects of the compound.
Chen X, Sun W, Gianaris NG, Riley AM, Cummins TR, Fehrenbacher JC, Obukhov AG.   +6 more
europepmc   +4 more sources