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TRPV1 activity and substance P release are required for corneal cold nociception [PDF]
, 2019 Guo, Changxiong +6 more
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Physiological roles of fatty acids and endocannabinoids in the nematode Caenorhabditis elegans [PDF]
Reisner, Kaja
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Transient Receptor Potential Vanilloid 1 and Xenobiotics
CNS & Neurological Disorders - Drug Targets, 2008Over the last couple of years, transient receptor potential vanilloid 1(TRPV1) channels have been a hot topic in ion channel research. Since this research field is still rather new, there is not much known about the working mechanism of TRPV1 and its ligands.
E, Cuypers +4 more
openaire +2 more sources
Modulation of Transient Receptor Vanilloid 1 Activity by Transient Receptor Potential Ankyrin 1
Molecular Pharmacology, 2014Transient receptor potential vanilloid 1 (TRPV1) is a nonselective ligand-gated cation channel responding to noxious heat, protons, and chemicals such as capsaicin. TRPV1 is expressed in sensory neurons and plays a critical role in pain associated with tissue injury, inflammation, and nerve lesions.
Viola, Spahn +2 more
openaire +2 more sources
The paradoxical role of the transient receptor potential vanilloid 1 receptor in inflammation
Pharmacology & Therapeutics, 2010The transient potential receptor vanilloid 1 (TRPV1) receptor is a non-selective cation channel that is chemically activated by capsaicin, the pungent component of hot peppers. In addition, endogenous compounds, in particular the endogenous cannabinoid receptor activator, anandamide, have been demonstrated to activate TRPV1 in vivo. TRPV1 receptors are
Alawi, Khadija, Keeble, Julie
openaire +3 more sources
Transient receptor potential vanilloid type 1 and pain development
Current Opinion in Pharmacology, 2012Transient receptor potential vanilloid type 1 (TRPV1), a ligand-gated cation channel, is a polymodal nocitransducer widely expressed within pain transmitting/modulating areas of the peripheral and central nervous system. TRPV1 is both activated and sensitized by inflammatory endogenous mediators during inflammatory pain conditions and appears to be up ...
PALAZZO, Enza +5 more
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Transient receptor potential vanilloid 1 as a therapeutic target in analgesia
Expert Opinion on Therapeutic Targets, 2013The selective excitatory action of capsaicin followed by long-term chemoanalgesia due to an action on the 'capsaicin receptor' of C-polymodal nociceptors, cloned 15 years ago, opened up fascinating perspectives for a class of nociceptor blocking analgesics.The TRPV1/capsaicin receptor is an integrative, chemoceptive, noxious heat-gated cation channel ...
János, Szolcsányi, Erika, Pintér
openaire +2 more sources
The Roles of Transient Receptor Potential Vanilloid 1 and 4 in Olfactory Regeneration
Laboratory Investigation, 2023Olfactory disorders, which are closely related to cognitive deterioration, can be caused by several factors, including infections, such as COVID-19; aging; and environmental chemicals. Injured olfactory receptor neurons (ORNs) regenerate after birth, but it is unclear which receptors and sensors are involved in ORN regeneration.
Hideki, Sakatani +10 more
openaire +2 more sources
Neuroscience, 2006
Cannabinoid type 1 receptors and transient receptor potential vanilloid type 1 channels have been proposed to act as metabotropic and ionotropic receptors, respectively, for two classes of endogenous polyunsaturated fatty acid amides, the acylethanolamides and the acyldopamides.
Luigia Cristino +2 more
exaly +3 more sources
Cannabinoid type 1 receptors and transient receptor potential vanilloid type 1 channels have been proposed to act as metabotropic and ionotropic receptors, respectively, for two classes of endogenous polyunsaturated fatty acid amides, the acylethanolamides and the acyldopamides.
Luigia Cristino +2 more
exaly +3 more sources
Molecular Pharmacology, 2012
Transient receptor potential vanilloid type 1 (TRPV1) is a nonselective cation channel activated by capsaicin, low pH, and noxious heat and plays a key role in nociception. Understanding mechanisms for functional modulation of TRPV1 has important implications.
Xuan, Zhang +7 more
openaire +2 more sources
Transient receptor potential vanilloid type 1 (TRPV1) is a nonselective cation channel activated by capsaicin, low pH, and noxious heat and plays a key role in nociception. Understanding mechanisms for functional modulation of TRPV1 has important implications.
Xuan, Zhang +7 more
openaire +2 more sources