Results 91 to 100 of about 804,926 (346)

Extragalactic transient candidates in the Second Swift-XRT Point Source catalogue [PDF]

, 2022
R. A. J. Eyles-Ferris, R. L. C. Starling, P. T. O’Brien, P. A. Evans   +3 more
openalex   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Bright Bursts with Submillisecond Structures of FRB 20230607A in a Highly Magnetized Environment

The Astrophysical Journal
We report the observations of a repeating FRB 20230607A for 15.6 hr spanning 16 months using the Five-hundred-meter Aperture Spherical Radio Telescope with the detection of 565 bursts.
DeJiang Zhou, J. L. Han, Bing Zhang, WeiWei Zhu, Wei-yang Wang, Yuan-Pei Yang, Yuanhong Qu, Yong-Kun Zhang, Yi Yan, Wei-Cong Jing, Shuo Cao, Jintao Xie, Xuan Yang, Shiyan Tian, Ye Li, Dongzi Li, Jia-Rui Niu, Zi-Wei Wu, Qin Wu, Yi Feng, Fayin Wang, Pei Wang   +21 more
doaj   +1 more source

GCRT J1745-3009 as a Transient White Dwarf Pulsar

, 2005
A transient radio source in the direction of the Galactic Center, GCRT J1745-3009, exhibited 5 peculiar consecutive outbursts at 0.33 GHz with a period of 77.13 minutes and a duration of ~10 minutes for each outburst.
Bing Zhang, Brinkworth C. S., Ferrario L., Janusz Gil, Jones P. B., Mestel L., Muslimov A. G., Steffen M.   +7 more
core   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

CSS 161010: A Luminous Fast Blue Optical Transient with Broad Blueshifted Hydrogen Lines

The Astrophysical Journal
We present ultraviolet, optical, and near-infrared photometric and optical spectroscopic observations of the luminous fast blue optical transient (LFBOT) CSS 161010:045834–081803 (CSS 161010).
Claudia P. Gutiérrez, Seppo Mattila, Peter Lundqvist, Luc Dessart, Santiago González-Gaitán, Peter G. Jonker, Subo Dong, Deanne Coppejans, Ping Chen, Panos Charalampopoulos, Nancy Elias-Rosa, Thomas M. Reynolds, Christopher Kochanek, Morgan Fraser, Andrea Pastorello, Mariusz Gromadzki, Jack Neustadt, Stefano Benetti, Erkki Kankare, Tuomas Kangas, Rubina Kotak, Maximilian D. Stritzinger, Thomas Wevers, Bing Zhang, David Bersier, Subhash Bose, David A. H. Buckley, Raya Dastidar, Anjasha Gangopadhyay, Aleksandra Hamanowicz, Juna A. Kollmeier, Jirong Mao, Kuntal Misra, Stephen. B. Potter, Jose L. Prieto, Encarni Romero-Colmenero, Mridweeka Singh, Auni Somero, Giacomo Terreran, Petri Vaisanen, Łukasz Wyrzykowski   +40 more
doaj   +1 more source

Design Consideration of a Longitudinal Kicker Cavity for Compensating Transient Beam Loading Effect in Synchrotron Light Sources

, 2021
Daichi Naito, S. Sakanaka, Takeshi Takahashi, Takaaki Yamaguchi, Naoto Yamamoto   +4 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Suzaku Observations of Four Heavily Absorbed HMXBs

, 2008
We report on Suzaku observations of four unidentified sources from the INTEGRAL and Swift BAT Galactic plane surveys. All the sources have a large neutral hydrogen column density and are likely members of an emerging class of heavily absorbed high mass X-
Abt, Bird, Bird, C. B. Markwardt, Chaty, D. C. Morris, Filliatre, Halpern, J. Tueller, K. S. Dhuga, Kudryavtsev, Levine, Markowitz, Markwardt, Markwardt, Negueruela, Negueruela, Negueruela, Patel, Patel, R. F. Mushotzky, R. K. Smith, Romano, Savonije, Sguera, Smith, T. R. Kallman, Tomsick, Tomsick, Tueller, Zurita Heras   +30 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source