Results 101 to 110 of about 241,409 (296)

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

An Extremely Active Repeating Fast Radio Burst Source in a Likely Nonmagneto-ionic Environment

The Astrophysical Journal
Fast radio bursts (FRBs) are bright radio bursts originating at cosmological distances. Only three repeating FRBs FRB 20121102A, FRB 20190520B, and FRB 20201124A among ∼60 known repeating FRBs have circular polarization.
Yi Feng, Di Li, Yong-Kun Zhang, Chao-Wei Tsai, Yuanhong Qu, Wei-Yang Wang, Yuan-Pei Yang, Pei Wang, Dengke Zhou, Jiarui Niu, Chenchen Miao, Mao Yuan, Jiaying Xu, Ryan S. Lynch, William Paul Armentrout, Brenne Gregory, Lingqi Meng, Shen Wang, Xianglei Chen, Shi Dai, Chen-Hui Niu, Mengyao Xue, Ju-Mei Yao, Bing Zhang, Junshuo Zhang, Weiwei Zhu, Jintao Xie, Yuhao Zhu   +27 more
doaj   +1 more source

Transient sources at the highest angular resolution [PDF]

Proceedings of 12th European VLBI Network Symposium and Users Meeting — PoS(EVN 2014), 2015
By definition transients are sudden events, some, like supernovae, are catastrophic, while others might be due to recurrent phenomena. The aim of studying transients is to reveal the physical conditions causing them, in this sense ideal targets for monitoring are transients in binary systems.
openaire   +2 more sources

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

A Comprehensive Study of the Energy and Redshift Distributions of the Fast Radio Burst Population Based on the First CHIME/FRB Catalog

The Astrophysical Journal
Fast radio bursts (FRBs) are brief, high-energy bursts of radio waves from extragalactic sources, and their origin remains an open question. In this paper, we perform a comprehensive analysis of the FRB population using the first CHIME/FRB catalog ...
Qing-Zhen Lei, Xin-Zhe Wang, Can-Min Deng   +2 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Modeling Current and Future High-cadence Surveys of Repeating Fast Radio Burst Populations

The Astrophysical Journal
In recent years, the Canadian Hydrogen Intensity Mapping Experiment (CHIME) interferometer has revealed a large number of fast radio bursts (FRBs), including a sizable population that demonstrates repeating behavior.
Kyle McGregor, Duncan R. Lorimer
doaj   +1 more source

Time domain imaging of transient and variable radio sources

, 2020
This thesis focuses on the study of transient and variable radio sources in the universe. Transient signals, unlike a source constantly visible, change in their brightness (or flux) over a certain length of time.
Cendes, Y.N.
core  

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source