Results 101 to 110 of about 807,144 (296)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

A Comprehensive Study of the Energy and Redshift Distributions of the Fast Radio Burst Population Based on the First CHIME/FRB Catalog

The Astrophysical Journal
Fast radio bursts (FRBs) are brief, high-energy bursts of radio waves from extragalactic sources, and their origin remains an open question. In this paper, we perform a comprehensive analysis of the FRB population using the first CHIME/FRB catalog ...
Qing-Zhen Lei, Xin-Zhe Wang, Can-Min Deng   +2 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Modeling Current and Future High-cadence Surveys of Repeating Fast Radio Burst Populations

The Astrophysical Journal
In recent years, the Canadian Hydrogen Intensity Mapping Experiment (CHIME) interferometer has revealed a large number of fast radio bursts (FRBs), including a sizable population that demonstrates repeating behavior.
Kyle McGregor, Duncan R. Lorimer
doaj   +1 more source

Precession in transient X-ray sources [PDF]

Nature, 1975
THE origin of both the relatively long period and the transient nature of the recently discovered X-ray sources Ariel 1118−61 (ref. 1) and Ariel 0535+26 (ref. 2), with pulse periods of about 405 and 104 s, respectively, and decay times of days, is unclear. The pulse rate of A1118−61 has been attributed to an extremely short binary star orbital period3,
openaire   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Radio Observations Point to a Moderately Relativistic Outflow in the Fast X-Ray Transient EP241021a

The Astrophysical Journal
Fast X-ray transients (FXRTs) are short-lived X-ray outbursts with diverse progenitor scenarios, including compact object mergers, stellar core collapses, and tidal disruption events.
Muskan Yadav, Eleonora Troja, Roberto Ricci, Yu-Han Yang, Mark H. Wieringa, Brendan O’Connor, Yacheng Kang, Rosa L. Becerra, Geoffrey Ryan, Malte Busmann   +9 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Evidence for Gravitational Lensing in FRB 20190320B: A Potential Lens Mass of ∼420 Solar Masses

The Astrophysical Journal
Due to their millisecond-duration pulses and high flux, fast radio bursts (FRBs) are ideal probes for detecting low-mass gravitational lensing signals, as their distinctive characteristics make them highly sensitive to subtle time delays and lensing ...
Shao-Wei Xiong, Shuo Xiao, Zheng-Huo Jiang, Yang Lai, Yan-Qiu Zhang, Ru-Shuang Zhao, Zi-Yi You   +6 more
doaj   +1 more source

Electrical discharge source for tropospheric “ozone‐rich transients”

Journal of Geophysical Research: Atmospheres, 2002
In situ trace gas (O3, NO, NO2, NOy) and ultrafine aerosol particle data from a passenger aircraft (project CARIBIC) and the NOAA WP‐3D research aircraft are used to identify the origin of “ozone‐rich transients” that occasionally appear in aircraft ozone data sets along flight distances of 5–80 km.
Zahn, A., Brenninkmeijer, C. A. M., Crutzen, P. J., Parrish, D. D., Sueper, D., Heinrich, G., Güsten, H., Fischer, H., Hermann, M., Heintzenberg, J.   +9 more
openaire   +3 more sources