Results 121 to 130 of about 4,124,580 (330)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Hunter, Robert C.

, 2021
Transient application card documenting relief requests and authorizations to the destitute by Transient Bureau of Kalamazoo County, under the Federal Emergency Relief Administration, May 1933 - June ...
Kalamazoo County (Mich.). Transient Bureau
core  

Sudden Polarization Angle Jumps of the Repeating Fast Radio Burst FRB 20201124A

The Astrophysical Journal Letters
We report the first detection of polarization angle orthogonal jumps, a phenomenon previously only observed from radio pulsars, from a fast radio burst (FRB) source FRB 20201124A.
J. R. Niu, W. Y. Wang, J. C. Jiang, Y. Qu, D. J. Zhou, W. W. Zhu, K. J. Lee, J. L. Han, B. Zhang, D. Li, S. Cao, Z. Y. Fang, Y. Feng, Q. Y. Fu, P. Jiang, W. C. Jing, J. Li, Y. Li, R. Luo, L. Q. Meng, C. C. Miao, X. L. Miao, C. H. Niu, Y. C. Pan, B. J. Wang, F. Y. Wang, H. Z. Wang, P. Wang, Q. Wu, Z. W. Wu, H. Xu, J. W. Xu, L. Xu, M. Y. Xue, Y. P. Yang, M. Yuan, Y. L. Yue, D. Zhao, C. F. Zhang, D. D. Zhang, J. S. Zhang, S. B. Zhang, Y. K. Zhang, Y. H. Zhu   +43 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Knight, Carl

, 2021
Transient application card documenting relief requests and authorizations to the destitute by Transient Bureau of Kalamazoo County, under the Federal Emergency Relief Administration, May 1933 - June ...
Kalamazoo County (Mich.). Transient Bureau
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Irwin, John R.

, 2020
Transient application card documenting relief requests and authorizations to the destitute by Transient Bureau of Kalamazoo County, under the Federal Emergency Relief Administration, May 1933 - June ...
Kalamazoo County (Mich.). Transient Bureau
core  

The Real and Pseudo Dispersion Measures of FRB 20220912A

The Astrophysical Journal
Fast radio bursts (FRBs) are millisecond-duration radio transients. As they propagate through the interstellar medium, they interact with free electrons, resulting in dispersion. The corresponding dispersion measure (DM) is referred to as the real DM (DM
Yi Feng, Dengke Zhou, Yongkun Zhang, Di Li, Jianhua Fang, Jiaying Xu, Chenyuan Xu, Jintao Xie   +7 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Gotowka, John

, 2020
Transient application card documenting relief requests and authorizations to the destitute by Transient Bureau of Kalamazoo County, under the Federal Emergency Relief Administration, May 1933 - June ...
Kalamazoo County (Mich.). Transient Bureau
core