Results 121 to 130 of about 241,409 (296)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Prediction of Multiwavelength Afterglows Associated with FRB 20200120E and FRB 20201124A

The Astrophysical Journal
Fast radio bursts (FRBs) are mysterious radio transients with uncertain origins and environments. Recent studies suggest that some active FRBs may originate from compact objects in binary systems.
Ke Bian, Can-Min Deng
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Flux Variations of Fast Radio Bursts and Their Persistent Radio Sources: Evidence for a Shared Progenitor

The Astrophysical Journal
Fast radio bursts (FRBs) are millisecond-duration extragalactic radio transients, some of which are associated with compact persistent radio sources (PRSs), hinting at a physical connection.
Xinming Li, Chen-Hui Niu, Jia-heng Zhang, Di Li, Bing Zhang, Yuan-Pei Yang, Pei Wang, Junshuo Zhang, Yongkun Zhang, Ye Li, Jiarui Niu, Xiaoping Zheng, Yunwei Yu, Yi Feng, Bo Zhang, Fayin Wang, Yuhao Zhu, A. Ming Chen, Ze-Xin Du, Jian Li, weihong li, Chenchen Miao, Weiyang Wang, Guang-Lei Wu, Ai Yuan Yang, Jumei Yao, Ru-Shuang Zhao   +26 more
doaj   +1 more source

Investigating Transient Patterns of Human Brain Activity in Normal Ageing

The global population is ageing rapidly, and with the increasing population age, comes an increasing need to understand the neurophysiological effects of ageing.
Power, Lindsey
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Constraints on Fast Radio Burst Population from the First CHIME/FRB Catalog with the Hierarchical Bayesian Inference

The Astrophysical Journal
Fast radio bursts (FRBs) have emerged as one of the most dynamic areas of research in astronomy and cosmology. Despite increasing number of FRBs having been reported, the exact origin of FRBs remains elusive.
Huan Zhou, Zhengxiang Li, Zong-Hong Zhu
doaj   +1 more source

Three transient X-ray sources during the INTEGRAL revolution 1710

, 2016
During recent INTEGRAL observations of the Musca and Norma regions (revolutions 1710) performed between 2016-08-05 16:00:36 UTC and 2016-08-07 21:02:14 UTC a renewed activity from the following transient X-ray sources has been detected: 1) IGR J17091 ...
Charles, Phil, Fiocchi, M., Bazzano, A., Bird, T., Chenevez, J., Ubertini, P.   +5 more
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

A Catalog of Local Universe Fast Radio Bursts from CHIME/FRB and the KKO

The Astrophysical Journal Supplement Series
We present the first catalog of fast radio burst (FRB) host galaxies from CHIME/FRB Outriggers, selected uniformly in the radio and the optical by localizing 81 new bursts to 2″ × ∼ 60″ accuracy using CHIME and the k’niʔatn k’l ⌣ stk’masqt Outrigger ...
The CHIME/FRB Collaboration, Mandana Amiri, Daniel Amouyal, Bridget C. Andersen, Shion Andrew, Kevin Bandura, Mohit Bhardwaj, P. J. Boyle, Charanjot Brar, Alyssa Cassity, Shami Chatterjee, Alice P. Curtin, Matt Dobbs, Fengqiu Adam Dong, Yuxin Dong, Gwendolyn M. Eadie, Tarraneh Eftekhari, Wen-fai Fong, Emmanuel Fonseca, B. M. Gaensler, Mark Halpern, Jason W. T. Hessels, Hans Hopkins, Adaeze L. Ibik, Ronniy C. Joseph, Jane Kaczmarek, Lordrick Kahinga, Victoria Kaspi, Kholoud Khairy, Charles D. Kilpatrick, Adam E. Lanman, Mattias Lazda, Calvin Leung, Robert Main, Lluis Mas-Ribas, Kiyoshi W. Masui, Ryan Mckinven, Juan Mena-Parra, Bradley W. Meyers, Daniele Michilli, Nikola Milutinovic, Kenzie Nimmo, Gavin Noble, Ayush Pandhi, Swarali Shivraj Patil, Aaron B. Pearlman, Emily Petroff, Ziggy Pleunis, J. Xavier Prochaska, Masoud Rafiei-Ravandi, Mubdi Rahman, Andre Renard, Mawson W. Sammons, Ketan R. Sand, Paul Scholz, Vishwangi Shah, Kaitlyn Shin, Seth R. Siegel, Sunil Simha, Kendrick Smith, Ingrid Stairs, Keith Vanderlinde, Haochen Wang, Dallas Wulf, Tarik J. Zegmott   +64 more
doaj   +1 more source