Results 111 to 120 of about 241,409 (296)

Radio Observations Point to a Moderately Relativistic Outflow in the Fast X-Ray Transient EP241021a

The Astrophysical Journal
Fast X-ray transients (FXRTs) are short-lived X-ray outbursts with diverse progenitor scenarios, including compact object mergers, stellar core collapses, and tidal disruption events.
Muskan Yadav, Eleonora Troja, Roberto Ricci, Yu-Han Yang, Mark H. Wieringa, Brendan O’Connor, Yacheng Kang, Rosa L. Becerra, Geoffrey Ryan, Malte Busmann   +9 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

A Time-domain Study of Repeat and Nonrepeat Fast Radio Bursts

The Astrophysical Journal
Fast radio bursts (FRBs) are extremely energetic radio transients, typically classified as repeat or nonrepeat, but their origins remain uncertain. In this work, we focus on the timing characteristics of the pulses in 536 FRBs observed by CHIME with ...
Zheng-Huo Jiang, Shuo Xiao, Pei Wang, Jiao-Jiao Yang, Tong-Lei Liao, Zi-Yi You, Di Li   +6 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Varying Activity and the Burst Properties of FRB 20240114A Probed with GMRT Down to 300 MHz

The Astrophysical Journal
Repeating fast radio bursts (FRBs) can exhibit a wide range of burst repetition rates, from none to hundreds of bursts per hour. Here we report the detection and characteristics of 60 bursts from the recently discovered FRB 20240114A, observed with the ...
Ajay Kumar, Yogesh Maan, Yash Bhusare
doaj   +1 more source

On the modelling of Transient Scattering under Ultra Wideband Sources

, 2010
Accurate modelling of electromagnetic radiation, scattering and propagation using ultra wideband (UWB) sources has been of significant interest with ongoing application in areas such as short-range communications, through-the-wall imaging, ground ...
Lui, Hoi Shun, Shuley, Nicholas V., Shuley, N. V. Z., Nicholas V. Shuley, Shuley, N.V., Lui, Hoi-Shun, Hoi-Shun Lui   +6 more
core   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Time lag in transient cosmic accreting sources

, 2017
Context. We develop models for time lag between the maxima of the source brightness in different wavelengths during a transient flash of luminosity that is connected with a short-period increase of the mass flux onto the central compact object ...
G. S. Bisnovatyi-Kogan, F. Giovannelli
core   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Evidence for Gravitational Lensing in FRB 20190320B: A Potential Lens Mass of ∼420 Solar Masses

The Astrophysical Journal
Due to their millisecond-duration pulses and high flux, fast radio bursts (FRBs) are ideal probes for detecting low-mass gravitational lensing signals, as their distinctive characteristics make them highly sensitive to subtle time delays and lensing ...
Shao-Wei Xiong, Shuo Xiao, Zheng-Huo Jiang, Yang Lai, Yan-Qiu Zhang, Ru-Shuang Zhao, Zi-Yi You   +6 more
doaj   +1 more source