Results 111 to 120 of about 227,458 (266)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Dinosaur in a Haystack: X-Ray View of the Entrails of SN 2023ixf and the Radio Afterglow of Its Interaction with the Medium Spawned by the Progenitor Star (Paper I)

The Astrophysical Journal
We present the results from our extensive hard-to-soft X-ray (NuSTAR, Swift-XRT, XMM-Newton, Chandra) and meter-to-millimeter-wave radio (Giant Metrewave Radio Telescope, Very Large Array, NOEMA) monitoring campaign of the very nearby ( d  = 6.9 Mpc ...
Nayana A. J., Raffaella Margutti, Eli Wiston, Ryan Chornock, Sergio Campana, Tanmoy Laskar, Kohta Murase, Melanie Krips, Giulia Migliori, Daichi Tsuna, Kate D. Alexander, Poonam Chandra, Michael Bietenholz, Edo Berger, Roger A. Chevalier, Fabio De Colle, Luc Dessart, Rebecca Diesing, Brian W. Grefenstette, Wynn V. Jacobson-Galán, Keiichi Maeda, Benito Marcote, Daisy Matthews, Dan Milisavljevic, Alak K. Ray, Andrea Reguitti, Ava Polzin   +26 more
doaj   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Eddington Envelopes: The Fate of Stars on Parabolic Orbits Tidally Disrupted by Supermassive Black Holes

The Astrophysical Journal Letters
Stars falling too close to massive black holes in the centers of galaxies can be torn apart by the strong tidal forces. Simulating the subsequent feeding of the black hole with disrupted material has proved challenging because of the range of timescales ...
Daniel J. Price, David Liptai, Ilya Mandel, Joanna Shepherd, Giuseppe Lodato, Yuri Levin   +5 more
doaj   +1 more source

Galactic transient sources with MAXI

Galactic transient sources with MAXI
Astrophysics with All-Sky X-Ray observations: 3rd International MAXI Workshop (RIKEN, 10-12 June 2008) Thanks to its superior sensitivity, energy resolution and wide energy coverage, MAXI is expected to open a new window in the study of Galactic X-ray transients.
openaire  

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

The Landscape of Collapsar Outflows: Structure, Signatures, and Origins of Einstein Probe Relativistic Supernova Transients

The Astrophysical Journal Letters
The Einstein Probe is revolutionizing time-domain astrophysics through the discovery of new classes of X-ray transients associated with broad-line Type Ic supernovae.
Ore Gottlieb
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

A Luminous and Hot Infrared through X-Ray Transient at a 5 kpc Offset from a Dwarf Galaxy

The Astrophysical Journal
We are searching for hot, constant-color, offset optical flares in the Zwicky Transient Facility data stream that are >10″ from any galaxy in public imaging data from the PanSTARRS survey. Here, we present the first discovery from this search: AT 2024puz,
Jean J. Somalwar, Vikram Ravi, Raffaella Margutti, Ryan Chornock, Priyamvada Natarajan, Wenbin Lu, Charlotte Angus, Matthew J. Graham, Erica Hammerstein, Edward Nathan, Matt Nicholl, Kritti Sharma, Robert Stein, Frank Verdi, Yuhan Yao, Eric C. Bellm, Tracy X. Chen, Michael W. Coughlin, David Hale, Mansi M. Kasliwal, Russ R. Laher, Reed Riddle, Jesper Sollerman   +22 more
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source