Results 111 to 120 of about 807,144 (296)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Prediction of Multiwavelength Afterglows Associated with FRB 20200120E and FRB 20201124A
The Astrophysical JournalFast radio bursts (FRBs) are mysterious radio transients with uncertain origins and environments. Recent studies suggest that some active FRBs may originate from compact objects in binary systems.
Ke Bian, Can-Min Deng
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
A Time-domain Study of Repeat and Nonrepeat Fast Radio Bursts
The Astrophysical JournalFast radio bursts (FRBs) are extremely energetic radio transients, typically classified as repeat or nonrepeat, but their origins remain uncertain. In this work, we focus on the timing characteristics of the pulses in 536 FRBs observed by CHIME with ...
Zheng-Huo Jiang +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Varying Activity and the Burst Properties of FRB 20240114A Probed with GMRT Down to 300 MHz
The Astrophysical JournalRepeating fast radio bursts (FRBs) can exhibit a wide range of burst repetition rates, from none to hundreds of bursts per hour. Here we report the detection and characteristics of 60 bursts from the recently discovered FRB 20240114A, observed with the ...
Ajay Kumar, Yogesh Maan, Yash Bhusare
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
The Astrophysical JournalFast radio bursts (FRBs) have emerged as one of the most dynamic areas of research in astronomy and cosmology. Despite increasing number of FRBs having been reported, the exact origin of FRBs remains elusive.
Huan Zhou, Zhengxiang Li, Zong-Hong Zhu
doaj +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source