Results 91 to 100 of about 227,458 (266)

A Time-domain Study of Repeat and Nonrepeat Fast Radio Bursts

The Astrophysical Journal
Fast radio bursts (FRBs) are extremely energetic radio transients, typically classified as repeat or nonrepeat, but their origins remain uncertain. In this work, we focus on the timing characteristics of the pulses in 536 FRBs observed by CHIME with ...
Zheng-Huo Jiang, Shuo Xiao, Pei Wang, Jiao-Jiao Yang, Tong-Lei Liao, Zi-Yi You, Di Li   +6 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Varying Activity and the Burst Properties of FRB 20240114A Probed with GMRT Down to 300 MHz

The Astrophysical Journal
Repeating fast radio bursts (FRBs) can exhibit a wide range of burst repetition rates, from none to hundreds of bursts per hour. Here we report the detection and characteristics of 60 bursts from the recently discovered FRB 20240114A, observed with the ...
Ajay Kumar, Yogesh Maan, Yash Bhusare
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Constraints on Fast Radio Burst Population from the First CHIME/FRB Catalog with the Hierarchical Bayesian Inference

The Astrophysical Journal
Fast radio bursts (FRBs) have emerged as one of the most dynamic areas of research in astronomy and cosmology. Despite increasing number of FRBs having been reported, the exact origin of FRBs remains elusive.
Huan Zhou, Zhengxiang Li, Zong-Hong Zhu
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

A Catalog of Local Universe Fast Radio Bursts from CHIME/FRB and the KKO

The Astrophysical Journal Supplement Series
We present the first catalog of fast radio burst (FRB) host galaxies from CHIME/FRB Outriggers, selected uniformly in the radio and the optical by localizing 81 new bursts to 2″ × ∼ 60″ accuracy using CHIME and the k’niʔatn k’l ⌣ stk’masqt Outrigger ...
The CHIME/FRB Collaboration, Mandana Amiri, Daniel Amouyal, Bridget C. Andersen, Shion Andrew, Kevin Bandura, Mohit Bhardwaj, P. J. Boyle, Charanjot Brar, Alyssa Cassity, Shami Chatterjee, Alice P. Curtin, Matt Dobbs, Fengqiu Adam Dong, Yuxin Dong, Gwendolyn M. Eadie, Tarraneh Eftekhari, Wen-fai Fong, Emmanuel Fonseca, B. M. Gaensler, Mark Halpern, Jason W. T. Hessels, Hans Hopkins, Adaeze L. Ibik, Ronniy C. Joseph, Jane Kaczmarek, Lordrick Kahinga, Victoria Kaspi, Kholoud Khairy, Charles D. Kilpatrick, Adam E. Lanman, Mattias Lazda, Calvin Leung, Robert Main, Lluis Mas-Ribas, Kiyoshi W. Masui, Ryan Mckinven, Juan Mena-Parra, Bradley W. Meyers, Daniele Michilli, Nikola Milutinovic, Kenzie Nimmo, Gavin Noble, Ayush Pandhi, Swarali Shivraj Patil, Aaron B. Pearlman, Emily Petroff, Ziggy Pleunis, J. Xavier Prochaska, Masoud Rafiei-Ravandi, Mubdi Rahman, Andre Renard, Mawson W. Sammons, Ketan R. Sand, Paul Scholz, Vishwangi Shah, Kaitlyn Shin, Seth R. Siegel, Sunil Simha, Kendrick Smith, Ingrid Stairs, Keith Vanderlinde, Haochen Wang, Dallas Wulf, Tarik J. Zegmott   +64 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Sudden Polarization Angle Jumps of the Repeating Fast Radio Burst FRB 20201124A

The Astrophysical Journal Letters
We report the first detection of polarization angle orthogonal jumps, a phenomenon previously only observed from radio pulsars, from a fast radio burst (FRB) source FRB 20201124A.
J. R. Niu, W. Y. Wang, J. C. Jiang, Y. Qu, D. J. Zhou, W. W. Zhu, K. J. Lee, J. L. Han, B. Zhang, D. Li, S. Cao, Z. Y. Fang, Y. Feng, Q. Y. Fu, P. Jiang, W. C. Jing, J. Li, Y. Li, R. Luo, L. Q. Meng, C. C. Miao, X. L. Miao, C. H. Niu, Y. C. Pan, B. J. Wang, F. Y. Wang, H. Z. Wang, P. Wang, Q. Wu, Z. W. Wu, H. Xu, J. W. Xu, L. Xu, M. Y. Xue, Y. P. Yang, M. Yuan, Y. L. Yue, D. Zhao, C. F. Zhang, D. D. Zhang, J. S. Zhang, S. B. Zhang, Y. K. Zhang, Y. H. Zhu   +43 more
doaj   +1 more source