Results 81 to 90 of about 227,458 (266)
The Astrophysical JournalFast radio bursts (FRBs) are brief, high-energy bursts of radio waves from extragalactic sources, and their origin remains an open question. In this paper, we perform a comprehensive analysis of the FRB population using the first CHIME/FRB catalog ...
Qing-Zhen Lei +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Modeling Current and Future High-cadence Surveys of Repeating Fast Radio Burst Populations
The Astrophysical JournalIn recent years, the Canadian Hydrogen Intensity Mapping Experiment (CHIME) interferometer has revealed a large number of fast radio bursts (FRBs), including a sizable population that demonstrates repeating behavior.
Kyle McGregor, Duncan R. Lorimer
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Evidence for Gravitational Lensing in FRB 20190320B: A Potential Lens Mass of ∼420 Solar Masses
The Astrophysical JournalDue to their millisecond-duration pulses and high flux, fast radio bursts (FRBs) are ideal probes for detecting low-mass gravitational lensing signals, as their distinctive characteristics make them highly sensitive to subtle time delays and lensing ...
Shao-Wei Xiong +6 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Prediction of Multiwavelength Afterglows Associated with FRB 20200120E and FRB 20201124A
The Astrophysical JournalFast radio bursts (FRBs) are mysterious radio transients with uncertain origins and environments. Recent studies suggest that some active FRBs may originate from compact objects in binary systems.
Ke Bian, Can-Min Deng
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
The Astrophysical JournalFast radio bursts (FRBs) are millisecond-duration extragalactic radio transients, some of which are associated with compact persistent radio sources (PRSs), hinting at a physical connection.
Xinming Li +26 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source