Results 61 to 70 of about 241,409 (296)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Searching for Transient Neutrino Sources with IceCube in Real-Time
, 2018 The IceCube neutrino observatory is a 1 km3 ^3 detector deployed deep in the Antarctic glacier. While IceCube recently discovered a diffuse astrophysical flux of high energy neutrinos, its sources are yet to be identified.
KINTSCHER, Thomas (8328903) +1 more
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
The Spectral and Temporal Properties of Transient Sources in Early-type Galaxies [PDF]
, 2012 We report the spectral and temporal variability properties of 18 candidate transient (TC) and potential transient (PTC) sources detected in deep multi-epoch Chandra observation of the nearby elliptical galaxies, NGC 3379, NGC 4278, and NGC 4697. Only one
Kim D. W. +10 more
core +2 more sources
Late-time Radio Flares in Tidal Disruption Events
The Astrophysical JournalRadio monitoring unveiled late (hundreds to a thousand days) radio flares in a significant fraction of tidal disruption events. We propose that these late-time radio flares are a natural outcome if the surrounding density profile flattens outside the ...
Tatsuya Matsumoto, Tsvi Piran
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
A Possible Periodic Rotation Measure Evolution in the Repeating FRB 20220529
The Astrophysical Journal LettersFast radio bursts (FRBs) are mysterious millisecond-duration radio transients of extragalactic origin. Some of them repeat, while others apparently do not.
Yi-Fang Liang +20 more
doaj +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Multiwavelength Observations of the Apparently Nonrepeating FRB 20250316A
The Astrophysical JournalThe physical origin of fast radio bursts (FRBs) remains uncertain. Although multiwavelength observations have been widely conducted, only Galactic FRB 20200428D is associated with an X-ray burst from the magnetar SGR J1935+2154.
Ye Li +74 more
doaj +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source