Results 71 to 80 of about 4,124,580 (330)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

The Nature of Optical Afterglows without Gamma-Ray Bursts: Identification of AT2023lcr and Multiwavelength Modeling

The Astrophysical Journal
In the past few years, the improved sensitivity and cadence of wide-field optical surveys have enabled the discovery of several afterglows without associated detected gamma-ray bursts (GRBs).
Maggie L. Li, Anna Y. Q. Ho, Geoffrey Ryan, Daniel A. Perley, Gavin P. Lamb, Nayana A.J., Igor Andreoni, G. C. Anupama, Eric C. Bellm, Edo Berger, Joshua S. Bloom, Eric Burns, Ilaria Caiazzo, Poonam Chandra, Michael W. Coughlin, Kareem El-Badry, Matthew J. Graham, Mansi Kasliwal, Garrett K. Keating, S. R. Kulkarni, Harsh Kumar, Frank J. Masci, Richard A. Perley, Josiah Purdum, Ramprasad Rao, Antonio C. Rodriguez, Ben Rusholme, Nikhil Sarin, Jesper Sollerman, Gokul P. Srinivasaragavan, Vishwajeet Swain, Zachary Vanderbosch   +31 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Delayed X-Ray Brightening Accompanied by Variable Ionized Absorption Following a Tidal Disruption Event

The Astrophysical Journal
Supermassive black holes can experience super-Eddington peak mass fallback rates following the tidal disruption of a star. The theoretical expectation is that part of the infalling material is expelled by means of an accretion disk wind, whose ...
T. Wevers, M. Guolo, D. R. Pasham, E. R. Coughlin, F. Tombesi, Y. Yao, S. Gezari   +6 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

McNear, Sam J.

, 2021
Transient application card documenting relief requests and authorizations to the destitute by Transient Bureau of Kalamazoo County, under the Federal Emergency Relief Administration, May 1933 - June ...
Kalamazoo County (Mich.). Transient Bureau
core  

Follow the Mass—A Concordance Picture of Tidal Disruption Events

The Astrophysical Journal
Three recent global simulations of tidal disruption events (TDEs) have produced, using different numerical techniques and parameters, very similar pictures of their dynamics.
Julian Krolik, Tsvi Piran, Taeho Ryu
doaj   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Parker, Thomas

, 2021
Transient application card documenting relief requests and authorizations to the destitute by Transient Bureau of Kalamazoo County, under the Federal Emergency Relief Administration, May 1933 - June ...
Kalamazoo County (Mich.). Transient Bureau
core  

Transient sources at the highest angular resolution [PDF]

Proceedings of 12th European VLBI Network Symposium and Users Meeting — PoS(EVN 2014), 2015
By definition transients are sudden events, some, like supernovae, are catastrophic, while others might be due to recurrent phenomena. The aim of studying transients is to reveal the physical conditions causing them, in this sense ideal targets for monitoring are transients in binary systems.
openaire   +2 more sources